Biol Psychiatry. 2016 Dec 1. pii: S0006-3223 (16) 33055-4. Doi: 10.1016 / j.biopsych.2016.11.011.
Cox BM1, Bentzley BS2, Regen-Tuero H2, Bona RE3, Reichel CM2, Aston-Jones G4.
inahaneloang
LITLHAHISO:
Bopaki bo bontša hore oxytocin, peptide ea tlhaho e tsejoang hantle ka karolo ea eona mekhoeng ea boits'oaro sechabeng, ho tsoala ngoana le ho anyesa, ke tšepiso ea litlhare e lematsang. Re sebelisitse mokhoa oa kahare oa nako ea boits'oaro-moruo (BE) lithutong ho hlahloba li-oxytocin e le motsoako oa litlhare oa lithethefatsi tsa methamphetamine (meth). Be paradigm e entsoe kamora ho latela mekhoa ea BE e sebelisitsoeng ho lekola tšusumetso ea lithethefatsi ho batho ba nang le tahi. Mefuta e tšoanang ea BE e lekiloeng ho mefuta eohle e bontšitsoe ho bolela esale pele boitšoaro bo tla khutla hamorao. Kahoo, bokhoni ba boithuto ba lithuto tsa pele tsa BE bo matla haholo.
LITLHAHISO:
Re ile ra leka litlamorao tsa systemic le microinfused oxytocin ya tlhokeho ya ho ipeha methapo e kenang kahare le ho khutlisetsoa ha methapo e tima bakeng sa likhoto tsa banna le tsa basali tse sebelisang BE paradigm. Likamano pakeng tsa tlhokeho ea methapo le ho batla meth.
LIKOTSO:
Liraka tsa basali li bontšitse tlhokeho e kholo (ke hore, tšusumetso) ea methapo ha e bapisoa le likhoto tsa banna. Likhotsong tsa banna le tsa basali, methapo e reretsoe ho khutlisetsoa hoa methapo, le systemic oxytocin e fokotse tlhoko ea methapo mme ea khutlisetsoa ho ho batla meth. Oxetocin o ne a sebetsa hantle haholo ho fokotseng tlhoko ea methapo le ho batla ho likhoto ka tšusumetso e matla ea lithethefatsi. Kamora nako, litla-morao tsena tsa "oxytocin" tsa systemic li ile tsa hokahanngoa ke liketso ho li-nucleus accumbens.
CONCLUSIONS:
Oxetocin e fokotsa tlhoko ea methane le ho batla ho batona le ba batšehali, mme litlamorao tsena li its'epahalla ho saena hoa oxytocin ho li-nucleus accumbens. Ka kakaretso, lintlha tsena li bontša hore nts'etsopele ea litlolo tse thehiloeng ho oxytocin e kanna ea ba mokhoa o ts'episang oa kalafo bakeng sa ts'ebeliso ea methapo ho batho.
LINKOTSO:
Tlatsetso; Moruo oa boitšoaro Methamphetamine; Oxetocin; Phetiso; Boitlhotlhollo
PMID: 28110822
DOI: 10.1016 / j.biopsych.2016.11.011
;
