Eur Neuropsychopharmacol. 2015 Oct 9. pii: S0924-977X (15) 00310-7. Doi: 10.1016 / j.euroneuro.2015.09.015.
Georgiou P1, Zanos P1, Garcia-Carmona JA2, Hourani S1, Kichine ea I1, Kieffer BL3, Laorden ML2, Bailey A4.
inahaneloang
Ho khutlela mokhoeng o seng molaong oa ho batla lithethefatsi ka tsela e seng molaong ke phephetso e kholo bakeng sa kalafo ea ho lemalla ha ho sena litlhare tse sebetsang tsa meriana. Haufinyane re bonts'itse hore ho kenya tšebetsong sistimi ea oxytocinergic ho thibela ho senyeha hoa maikutlo le khatello ea maikutlo e amanang le ho tlosoa hoa opioid. Mona, re fuputse hore na ooxtocin analogue carbetocin (CBT) e khona ho khutlisa morphine-primed primed of restend-place preference (CPP) ka litoeba.
Mochine o totobatsang phello ea boitšoaro ba CBT o ile oa hlahlojoa ka ho lekola ho kenya letsoho ha lits'ebetso tsa striatal noradrenergic le dopaminergic ho CBT phetoho ea ho qala hape ka khatello ea maikutlo le ts'usumetso ea khatello ea maikutlo ea CPP ea opioid. Ntle le moo, ha re fuoa bopaki ba morao-rao bo bonts'a ho ba teng ha ts'ebelisano ea oxytocin receptor (OTR) -μ-opioid receptor (MOPr) bokong, re ile ra boela ra lekola litšebelisano tsena ka ho etsa li-OTR autoradiographic binding bokong ba litoeba tse sa hlokeng MOPr.
Tsamaiso ea CBT e thibetse ho khutlisetsa pele ho khothaletsoa ha morphine CPP. Ha litlamorao tse matla tsa CBT ho ntlafatsa phetoho ea dopamine li ile tsa bonoa kamora khatello ea maikutlo le ea ho phahamisa litšusumetso, CBT e fokotsehile haholo ho fetoha ha striatal noradrenaline feela kamora ho khutlisetsoa ha priming-induction. Ntle le moo, keketseho e kholo ea tikoloho ea boko ba OTR e hlokometsoe ho litoeba tsa MOPr, ho bonts'a ho ba teng ha tšebelisano ea OTR-MOPr, e ka amehang molemong oa ho khutla hape.
Liphetho tsena li ts'ehetsa sistimi ea oxytocinergic e le sepheo se ts'episang ho thibela ts'oaetso ea ts'ebeliso ea opioid hape e totobatsa ho kenya letsoho ha mekhahlelo ea li-monoaminergic litlamorao tsa ho hlohlelletsa OTR ho thibela khatello ea maikutlo le ho phahamisa ho khothaletsa boitšoaro ba CPP.
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