Kuiper, LB le Coolen, LM
https://doi.org/10.1007/s11930-018-0157-2
Preclinical and Psychophysiology (F Guarraci le L Marson, Bahlophisi ba Karolo)
inahaneloang
Morero oa Tlhahlobo
Boitšoaro bo matla ba thobalano (CSB) e nkoa e le "bokhoba ba boits'oaro", 'me e sokela bophelo bo botle le' meleng le kelellong. Leha ho le joalo, CSB e liehile ho tsejoa ka tliliniki e le lefu le tšoaetsang. CSB e sebelisana hantle le mathata a amanang le mathata a amanang le tšebeliso ea lithethefatsi, 'me liphuputso tsa morao-rao tse entsoeng morao tjena li bonts'itse mathata a arolelanoang a neural pathologies, haholo-holo libakeng tsa boko tse laolang ho hlohlona ho susumetsang le taolo ea thibelo.
Liphihlelo tsa moraorao
Boithuto ba kliniki ea neuroimaging bo hlahlojoa bo tšoaileng liphetoho tsa sebopeho le / kapa ts'ebetso ho cortex ea pele, amygdala, striatum, le thalamus ho batho ba nang le bothata ba CSB. Mohlala oa tlhahlobo ea pele ea ho ithuta ho kenella ka tlase ho CSB litotong tsa banna ho tšohloa ho kenyeletsa le mokhoa oa ho khesa ho hlahloba ho batla boitšoaro ba thobalano leha ho sa tsejoe ka litlamorao tse mpe. U sebelisa mohlala ona oa preclinical, karolo ea cialex ea medial prefrontal e ile ea bonoa, ho kenyeletsoa polasetiki ea neural nakong ea komorbidity ea CSB le tlhekefetso ea psychostimulant.
Summary
Tlhahlobo ena e akaretsa lithuto tsa morao-rao tsa boitšoaro ba motho le tsa neuroimaging, ho kenyelletsa le mehlala ea preclinical e ka sebelisoang ho ithuta li-neurobiology tsa CSB.
Mantsoe a bohlokoa - Boitšoaro bo hlephileng ba thobalano, Thobalano ea botona le botšehali, Lithethefatsi
Hobane CSB e arolelana litšobotsi le mathata a mang a qobelloang, e leng tšebeliso ea lithethefatsi, papiso ea lipapiso ho CSB, le lithuto tse lemaletseng lithethefatsi, li ka ba tsa bohlokoa ho khetholla li-pathologies tse tloaelehileng tsa neural mediation comorbidity tsa mathata ana. Ho joalo, liphuputso tse ngata li bonts'itse mekhoa e ts'oanang ea ts'ebetso ea neural le kgokahanyo ka har'a meaho ea maoto e amehang ho CSB le tšebeliso e mpe ea lithethefatsi [87-89]. Mohlala, ho bakuli ba lemaletseng koae, koae ho feta likarolo tsa ts'ebetso ea cocaine le likamano tsa botona le botšehali, ho kenyelletsa le sebaka sa likarolo tse kenang tsa mokokotlo, amygdala, li-nucleus ascords, orbitofrontal cortex le insort cortex [90]. Phuputsong ea morao-rao ea FMRI ea Moeller le basebetsi mmoho le eena, batho ba nang le bothata ba tšebeliso ea koae ba khethile ho sheba litšoantšo tse amanang le koae hangata ho feta taolo e ntle, khetho e amanang le ts'ebetso ea neural sebakeng sa dorsal anterior cingrate cortex le sebaka sa ventral tegmental [91], tse libaka tse fumanoeng li lula li susumetsoa ke mofuta oa ts'usumetso ea boits'oaro [92]. Ho khahlisang, tlhahlobo ena e fumane hore ts'ebetso e kholo ho oralofetoal cortex, eo hape e bontšitsoeng e hlahisoa ka ho shebella litšoantšo tse tsosang takatso ea botona le botšehali [93], e amanang le khetho e tlase ea ho sheba litšoantšo tse amanang le koae, mohlomong e le sesupo sa ketsahalo e amanang le karabelo e khelohang. [91].
Qetellong, tlhahlobo ena e akaretsa lithuto le boitšoaro bo bobe ho CSB ea motho le ho hlonama ka mathata a mang, ho kenyeletsa tlhekefetso ea lithethefatsi. Ka kopanelo, lithuto tsena li bonts'a hore CSB e hokahane le liphetoho tse sebetsang ho dorsal anterior cingrate le preortal cortex, amygdala, striatum, le thalamus, ntle le phokotso ea khokahano pakeng tsa amygdala le preortal cortex. Ntle le moo, ho hlalositsoe mohlala oa CSB litotong tsa banna, ho kenyelletsoa le bopaki bo bocha ba liphetoho tsa neural ho mPFC le OFC tse amanang le tahlehelo ea taolo ea boitšoaro ba thobalano. Mohlala ona oa preclinical o fana ka monyetla o ikhethang oa ho hlahloba litlhatlhobo tsa mantlha ho tseba hore na li-predispositions le lisosa tsa CSB le comorbidity tse nang le mathata a mang
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