LIPOTSO: Ithuta ka litaba tse nang le tšusumetso e mpe (tšenyo ea botona le botšehali / thobalano) e tlaleha liphetoho tse etsahalang ka seiponeng tse etsahalang bokhobeng ba joala. Liphetoho tsa epigenetic li etsahetse ka liphatsa tsa lefutso tse amanang le sistimi ea oxytocin (e bohlokoa leratong, tlamahanong, bokhobeng, khatello ea maikutlo, jj.). Lintlha-kholo:
- Likamano tsa thobalano / lithethefatsi tsa lithethefatsi tsa epigenetic li shebahala li tšoana le makhoba a tahi
- Liphuputso tsa boithuto li tsamaellana le Kuhn le Gallinat, 2014 (thuto e tummeng ea fMRI ho basebelisi ba porno)
- Liphumano li ka supa ts'ebetso ea khatello ea maikutlo (e leng phetoho ea bohlokoa tšebelisong)
- Phetoho mefuteng ea oxytocin e ka ama tlamahano, khatello ea maikutlo, ts'ebetso ea thobalano, jj.
Bakeng sa tse ling, bala sengoloa sena sa botekgeniki: Bo-rasaense ba tseba hore na lihormone li hokahane le lefu la hypersexual
——————————————————————————————————————-
Adrian E. Boström, Andreas Chatzittofis, Diana-Maria Ciuculete, John N. Flanagan, Regina Krattinger, Marcus Bandstein, Jessica Mwinyi, Gerd A. Kullak-Ublick, Katarina Görts Öberg, Stefan Arver, Helgi B. Schiöth le Jussi Jokinen (2019) )
Li-Epigenetics, DOI: https://doi.org/10.1080/15592294.2019.1656157
inahaneloang
Hypersexual disorder (HD) e ile ea khothalletsoa e le ts'oaetso ho DSM-5 mme sehlopha sa sehlopha sa 'Compulsive Sexual Behaeve Disorder' se hlahisoa e le bothata ba taolo ea tšusumetso ho ICD-11. HD e kenyelletsa mekhoa e mengata ea pathophysiological; ho kenyelletsa ho hobella, ho qobelloa, takatso ea thobalano le bokhoba ba thobalano. Ha ho thuto e fetileng e ileng ea etsa lipatlisiso ka HD tlhahlobisong ea methyl e lekanyelitsoeng ho li-site tsa MicroRNA (miRNA) tse amanang le CpG. Mokhoa oa genome wide methylation o ile oa lekanngoa maling ohle ho tsoa ho lithuto tsa 60 tse nang le baithaopi ba phetseng hantle ba 33 ba sebelisang Illumina EPIC BeadChip. 8,852 miRNA e amanang le CpG-libaka li ile tsa etsoa lipatlisiso litekanyetsong tse ngata tsa methapo ea methapo M ho litekanyetso tse ikemetseng tsa lefu la lefu (HD kapa moithaopi ea phetseng hantle), li lokisa li-covariate tse ikemiselitseng ka botlalo. Maemo a ho hlalosoa ha li-miRNA tse khethiloeng a ile a hlahlojoa ho batho ba tšoanang bakeng sa tlhahlobo ea polelo e fapaneng. Candidate methylation loci e ile ea ithutoa hape bakeng sa ho ba le setsoalle le ts'ebeliso ea ts'ebeliso ea joala ho sehlopha se ikemetseng sa lithuto tsa 107. Liwebsaete tse peli tsa CpG e ne e le tsa bohlokoa moeling oa HD - cg18222192 (MIR708) (p <10E-05,pFDR = 5.81E-02) le cg01299774 (MIR4456) (p <10E-06, pFDR = 5.81E-02). MIR4456 e ne e le tlase haholo e hlahisitsoe ka HD ho li-univariate ka bobeli (p <0.0001) le multivariate (p <0.05). Methati ea Cg01299774 ea methylation e ne e hokahantsoe ka mokhoa o fapaneng le maemo a polelo ea MIR4456 (p <0.01) hape e ne e khethollotsoe ka mokhoa o fapaneng le ts'ebeliso ea joala (p = 0.026). Ponelopele ea liphatsa tsa lefutso tsa Gene le tlhahlobo ea tsela e senotse hore MIR4456 e beha liphatsa tsa lefutso ka mokhoa o khethollang bokong le tse amehang mekhoeng e meholo ea limolek'hule ea neuronal eo ho nahanoang hore e nepahetse bakeng sa HD, mohlala, tsela e tšoaeang oxytocin. Ka kakaretso, thuto ea rona e kenyelletsa tlatsetso e ka bang teng ea MIR4456 ho pathophysiology ea HD ka ho susumetsa ponts'o ea oxytocin.
HO TSOA KARABO KAROLO
Ka tlhahlobo ea mokhatlo oa methapo ea methapo ea methapo ea methapo ea mali maling, re supa libaka tsa CpG tse ikhethileng le MIR708 le MIR4456, tse khetholloang haholo ho bakuli ba HD. Ntle le moo, re bonts'a hore hsamiR- 4456 e amanang le methylation locus cg01299774 e fapana ka mokhoa o fapaneng le ts'ebeliso ea lino tse tahang, e fana ka maikutlo a hore e kanna ea amahanngoa le karolo ea tlatsetso e boneng ho HD.
Ho tsebo ea rona, ha ho pampiri e fetileng e hlalositseng bohlokoa ba MIR4456 maemong a psychopathologies. Rea tseba hore miRNA ena e bolokiloe ka mokhoa o iphetotseng mabapi le sebopeho sa tatellano ea tatellano ebile e boletsoe esale pele likarolo tsa boea ba hairpin ho tloha ho ba teng ha lipalo. Ntle le moo, re fana ka bopaki ba hore sepheo sa li-mRNA tse behang MIR4456 li bontšoa ka mokhoa o ikhethang ho amygdala le hippocampus, libaka tse peli tsa boko tse khothaletsoang ke Kühn et al. ho ba le tšusumetso ho pathophysiology ea HD [5].
Ho kenya letsoho ha tsela ea lets'oao la oxytocin le bonts'itsoeng thutong ena ho bonahala ho na le tšusumetso e matla ho litšoaneleho tse ngata tse hlalosang HD joalo ka ha ho boletsoe ke Kafka et al. [1], joalo ka takatso ea thobalano, ho qobelloa, ho kenella le ts'ebetso ea thobalano. Haholo-holo e hlahisoang ke "nucleus" ea "hypothalamus" mme e hlahisoa ke posterior pituitary, oxetocin e etsa karolo ea bohlokoa ho tlamahanng ea setsoalle le tsoalo ea botona le botšehali ho banna le ba batšehali [59]. Murphy et al. e hlalositse maemo a phahameng nakong ea thobalano [60]. Burri et al. e fumane hore ts'ebeliso ea intraasal oxetocin ho banna e felletse ka keketseho ea maemo a epinephrine plasma nakong ea thobalano le pono e fetotsoeng ea arousal [61]. Ntle le moo, ho 'nile ha etsoa tlhahiso ea hore oxytocin e thibelle ts'ebetso ea li-axis tsa hypothalamic-pituitary-adrenal (HPA) nakong ea khatello ea maikutlo. Jurek et al. o hlokometse hore li-oxytocin receptormediated intracellular mechanisms li chechisa phetisetso ea corticotropin-releasing factor (Crf) sebakeng sa "nucleus" ea genus, gene e amanang haholo le karabelo ea khatello ea maikutlo [62].
Liphetoho tseleng e tlohang ponelong ea oxytocin li ka hlalosa se fumanoeng ke Chatzittofis et al., Ea hlokometseng ho tsitsipana ha HPA axis ho banna ba nang le lefu la hypersexual [3]. Ho feta moo, liphuputso li bonts'a hore oxytocin e kanna ea ameha ho pathophysiology ea obsessive-activive disorder [63]. Ho sebelisana ha oxytocin le sistimi ea dopamine, HPA-axis le sesole sa 'mele li lebisitse ho phatlalatso ea hore liphapang tsa motho ka mong maemong a oxetocin li ama tlokotsing ea ho lemalla [64]. Le ha oxytocin e kile ea amahanngoa le taolo ea boitšoaro ba sechaba le bo mabifi, Johansson et al. e boetse e bonts'itse hore phapang ea liphatsa tsa lefutso ho oxytocin receptor gene (OXTR) e amme tloaelo ea ho etsa maemo maemong a phahameng a bohale tlasa ts'ebetso ea joala [65]. Qetellong, Brüne et al. o phethile ka hore ho fetoha hoa liphatsa tsa lefutso ho OXTR ho ka kenya letsoho ho hlaloseng pathophysiology ea humanlineline disorder [66], pathology e khetholloang ke dysregulation e matla [66].
MIR4456may e na le ts'ebetso e eketsehileng ea taolo ho HD e sa kang ea senoloa thutong ea hona joale. Tumellanong le seo re se fumaneng, liphuputso tse fetileng li tlalehile mekhatlo ea banna le basali bao ho thoeng ba kenelletse ts'ebetsong ea botona le botšehali ho batho ba tepelletseng maikutlong [67]. Ntle le moo, karolo e ka etsahalang ea 3'-5'-cyclic adenosine mono phosphate (cAMP) tekong ea thobalano e bonts'itsoe ho likhoto tsa basali, ka ho fetolela phosphoprotein- 32 le ho lebisa ho liphetoho tsa progestin receptors [68]. Ho khahlisang, cAMP e boetse e laola limolek'hule tse amanang le tataiso ea axon [69], joalo ka mofuta oa B3gnt1, o neng o amana le boitšoaro bo bobe ba thobalano ho litoeba tsa banna.
SEHLOOHO SA SEBELE KA HO ITHUTA:
Bo-rasaense ba tseba hore na lihormone li hokahane le lefu la hypersexual
Phuputso e ncha ea banna le basali ba nang le lefu la hypersexual e senotse hore na ho ka etsahala karolo efe ea qoqiso ea lihormone, ho latela liphetho tse phatlalalitsoeng koranteng. Epigenetics. Ho fumana ho ka bula monyetla oa ho phekola lefu lena ka ho ba engineering mokhoa oa ho thibela tšebetso ea lona.
Hypersexual disorder, kapa tšebeliso e fetelletseng ea thobalano, e nkoa e le bothata bo qobelloang ba boitšoaro ba thobalano, bo thathamisitsoeng e le bothata bo laolang khatello e seng molaong ke Mokhatlo oa Lefatše oa Bophelo. E ka khetholloa ke menahano e tsosang ea thobalano, ho qobelloa ho etsa liketso tsa thobalano, tahlehelo ea taolo, kapa litloaelo tsa thobalano tse nang le mathata kapa likotsi. Le ha tekanyetso ea tšoaetso e fapana, lingoliloeng li bonts'a hore khatello ea maikutlo e ama 3-6% ea baahi.
Phehisano e pota-potile ts'oaetso hobane e hangata e hlaha haufi le litaba tse ling tsa bophelo bo botle ba kelello, ho fana ka maikutlo a hore e ka ba tlatsetso kapa ponahatso ea bofokoli ba kelello bo teng. Hanyane hanyane ho tsejoa ka ts'ebetso ea methapo ea kutlo.
Mongoli ea etelletseng pele Adrian Boström oa Lefapha la Neuroscience Univesithing ea Uppsala, Sweden o re: "Re ikemiselitse ho etsa lipatlisiso ka mekhoa ea taolo ea epigenetic e ts'ehetsang ts'oaetso ea hypersexual e le hore re tsebe hore na e na le matšoao a e khethollang ho tse ling tsa bophelo bo botle." ithute le bafuputsi ba tsoang Andrology / Sexual Medicine Group (ANOVA) Karolinska Institutet, Stockholm, Sweden.
"Ho ea ka tsebo ea rona, thuto ea rona ke ea pele ho kenyelletsa mekhoa e sa sebetseng ea epigenetic ea DNA methylation le ts'ebetso ea microRNA le ho kenella ha oxytocin bokong har'a bakuli ba batlang kalafo ea bosodoma."
Bo-rasaense ba lekantsitse lipaterone tsa methapo ea methapo maling maling ho tsoa ho bakuli ba 60 ba nang le hypersexual disc mme ba li bapisa le mehlala e tsoang ho baithaopi ba phetseng hantle ba 33.
Ba fuputse libaka tsa 8,852 tsa methapo ea methapo ea DNA e amanang le li-microRNA tse haufi ho bona phapang lipakeng tsa sampole. DNA methylation e ka ama mofuta oa gene le tšebetso ea liphatsa tsa lefutso, ka tloaelo li etsang lintho ho fokotsa tšebetso ea bona. Moo ho neng ho fumanoe liphetoho methapong ea methapo ea methapo ea methapo ea methapo ea methapo ea methapo, bafuputsi ba ile ba etsa lipatlisiso tsa mofuta oa polelo ea MicroRNA e amanang. Li-MicroRNA li khahla haholo hobane li khona ho fetisa tšitiso ea mali-bokong 'me li fetole kapa li nyenyefatse polelo ea mefuta e ka bang makholo a' maloa e fapaneng bokong le liseleng tse ling.
Ba boetse ba bapisa seo ba se fumaneng le mehlala e tsoang lithutong tsa 107, 24 bao ba neng ba lemaletse joala, ho hlahloba mokhatlo le boitšoaro bo bobe.
Liphetho li supile libaka tse peli tsa DNA tse fetotsoeng ho bakuli ba nang le khatello ea maikutlo. Ts'ebetso e tloaelehileng ea methylation ea DNA e ile ea sitisoa mme MicroRNA e amanang, e amehang ho feliseng gene, e fumanoe e sa hlalosehe. Patlisiso e senotse hore microRNA e khethollotsoeng, microRNA-4456, e lebisa mefuta ea tlhaho e hlalosoang ka mokhoa o phahameng ka ho fetisisa bokong mme e amehang taolong ea qoqotho ea hormone. Ha ho felisoa ha gene ho khutsisitsoe, ho ka lebelloa hore oxytocin e tla ba maemong a phahameng, leha thuto ea hona joale e sa netefatse sena.
E bonoe ka mefuta e ikhethang ea li-vole le primate eo neuropeptide oxytocin e bapala karolo ea mantlha taolong ea boitšoaro ba tlamahano. Boithuto bo fetileng bo bontšitse hore oxetocin e amana le molaoana oa tlamahano ea batho ba babeli le ba babeli, ho tsoala thobalano le boitšoaro bo mabifi ho banna le basali. Ho bapisoa le lithuto tse itšetlehileng ka joala ho senotse sebaka se le seng sa DNA hore e tlase haholo, e fana ka maikutlo a hore e kanna ea amahanngoa le likarolo tse lemalloang ke khatello ea maikutlo, tse kang bokhoba ba thobalano, takatso e matla ea ho ba le thobalano, ho qobelloa le ho ts'oaroa.
"Ho tla hlokahala lipatlisiso tse ling ho fuputsa karolo ea microRNA-4456 le oxytocin ho ts'oaetso ea hypersexual, empa liphetho tsa rona li bontša hore ho ka ba molemo ho hlahloba melemo ea lithethefatsi le kalafo ea kelello ho fokotsa ts'ebetso ea oxytocin," ho bolela Moprofesa Jussi Jokinen oa Umeå. Univesithi, Sweden.
Bangoli ba hlokomela hore moeli oa boithuto ke hore phapang e kholo ea methapo ea DNA lipakeng tsa bakuli ba nang le khatello ea maikutlo le baithaopi ba phetseng hantle e ne e le haufi le 2.6%, ka hona, phello ea liphetoho tsa 'mele e kanna ea botsoa. Leha ho le joalo, 'mele o ntseng o hola oa litlhahiso tse fanang ka liphetoho tse poteletseng tsa methapo e ka ba le litlamorao tse fapaneng bakeng sa maemo a rarahaneng a joalo ka khatello ea maikutlo kapa lefu la kelello.
###
Boithuto bona bo tšehelitsoe ka tumellano ea lebatooa pakeng tsa Univesithi ea Umeå le Lekhotla la Setereke sa Västerbotten (ALF) le lithuso tse fanoeng ke Lekhotla la Setereke sa Stockholm hammoho le Sweden Research Foundation, Foundationhlens Foundation, Novo Nordisk Foundation, le Sweden Brain Research Motheo.
SEHLOOHO SA SEBELE KA HO ITHUTA:
Liphetoho tsa Epigenetic tse hokahaneng le khatello ea kelello le bokhoba ba tlatsetso
MedicalResearch.com Puisano le: Adrian E. Boström MD, lebitsong la bangoli
Lefapha la Neuroscience, Univesithi ea Uppsala, Sweden
MedicalResearch.com: Bohlokoa ba thuto ee ke bofe?
Karabo: Le ha tekanyetso ea tšoaetso e ntse e fapana, lingoliloeng li supa hore khatello ea maikutlo (HD) e ama 3-6% ea baahi. Leha ho le joalo, phehisano e pota-potile tlhahlobo eo 'me ha ho tsejoe ho honyenyane mabapi le ts'ebetso ea methapo ea kutlo.
Boloetse ba Hypersexual ha bo so ka bo batlisisoa mabapi le epigenomic le transcriptomics ka mokhoa o sa lefelloeng oa ho ithuta 'me ha ho tsejoe hanyane ka neurobiology e bakang bothata bona. Re ile ra fuputsa hore na ho na le liphetoho tsa epigenetic tse amang tšebetso ea liphatsa tsa lefutso le polelo ho bakuli ba hypersexual disorder (HD) mme ra fumana microRNA e sa sebetseng eo ho lumeloang hore e ama mochini oa tšebetso oa hormone oxytocin bokong.
Oxytocin e tsejoa e na le litšusumetso tse fapaneng tsa boits'oaro. Ho ea ka tsebo ea rona, ha ho thuto e fetileng e faneng ka bopaki ba kamano pakeng tsa methylation ea DNA, ts'ebetso ea microRNA le oxytocin ho ts'oaetso ea hypersexual. Liphuputso tsa rona li tšoaneloa ke lipatlisiso tse ling ka karolo ea MIR4456 mme haholo-holo Oxytocin ho ts'oaetso ea hypersexual. Ho hlokahala lithuto tse ling ho netefatsa karolo ea Oxytocin ho HD le ho batlisisa hore na kalafo e nang le kalafo ea bahanyetsi ba oxytocin e ka ba le litlamorao tse ntle ho bakuli ba nang le lefu la hypersexual.
MedicalResearch.com: Sepheo sa mantlha ke sefe?
Karabo: - Thutong ena re fuputse ka 8000 e fapaneng ea methapo ea DNA e hlophisitsoeng ka mokhoa o se nang khatello ea maikutlo le ka mokhoa o sa tsitsang. Ka hona, re ile ra hlolloa 'me ra hlolloa ho tseba liphatsa tsa lefutso tse sebetsanang le phetoho ea mantlha e hlalositsoeng ka bokong' me li ameha mekhoeng e meholo ea limolek'hule ea methapo eo ho nahanoang hore e ea sebetsa bakeng sa khatello ea maikutlo, mohlala, tsela ea lets'oao la oxytocin. Sena microRNA hape e bonahala e le ho iphetola hoa lintho ho bolokiloe ho pholletsa le malinyane, eo hape e leng ntho e khahlisang le e sa lebelloang.
MedicalResearch.com: Babali ba lokela ho tlosa eng tlalehong ea hau?
Karabo: Hypersexual disorder e kenyelletsa mekhoa e fapaneng ea pathophysiological ho kenyelletsa ho kena bohlasoa, ho qobelloa, ho se tsose takatso ea thobalano le ho lemalla ho kopanela liphate. Sena se ka hlalosoa e le hore khatello ea kelello e na le lintho tse lemalloang, empa ha ea lokela ho bonoa e le temallo feela. Seo re se fumaneng, ka leseli la crossover le ts'oaetso ea joala, se fana ka maikutlo a hore MIR4456 le tsela e tšoaeang oxytocin e ka ba karolo ea mantlha le karolo e tlatsetsang ea hypersexual disorder. Ho hlokahala lithuto tse ling ho netefatsa sena.
MedicalResearch.com: U khothaletsa lipatlisiso life nakong e tlang ka lebaka la mosebetsi ona?
Karabo: Liphetho tsa rona li khothaletsa lipatlisiso tse ling ka katleho ea, mohlala, oxytocin e laolang kalafo ea lithethefatsi ho bokuli ba ts'oaetso e ka tlatsetsang likhethong tsa kalafo tsa nalane ho ntlafatsa sephetho sa ba amehileng. Ntle le moo, re khetholla microRNA (miRNA) e itseng eo li-miRNA tse laolang lithethefatsi tse ka bang teng nakong e tlang li ka lekiloeng bothateng ba hypersexual.
MedicalResearch.com: Na ho na le ntho e 'ngoe hape eo u ka ratang ho e eketsa?
Karabo: DNA ea rona ke liphatsa tsa lefutso tsa liphatsa tsa lefutso tse fetolelang ka tatellano e fapaneng ea li-amino acid tse bitsoang liprotheine. Liprotheine le tsona ke karolo ea mantlha ea lintho tsohle tse phelang. DNA ea rona e futsitsoe mme ha e fetohe ha nako e ntse e tsamaea. Phuputso ena, leha ho le joalo, e ne e amana le epigenetics, e leng liphetoho tse amang tšebetso ea liphatsa tsa lefutso le polelo. Mesebetsi ena ea epigenetic e fetoha ha nako e ntse e tsamaea 'me e ka fokolloa ke mafu a itseng. Ho na le mekhoa e fapaneng ea epigenetic.
Thutong ena, re ithutile DNA methylation (mohato o tsejoang ho susumetsa ponahalo ea liphatsa tsa lefutso, ke hore, bongata ba lefutso le fetoleloang ho protheine) le ts'ebetso ea microRNA (likarolo tse khuts'oane tsa lefutso tse sa ngoliseng tse ka susumetsang phetolelo ea makholo a 'maloa liphatsa tsa lefutso tse fapaneng).
Ha re bapisa bakuli ba nang le ts'oaetso ea hypersexual le baithaopi ba phetseng hantle, re hlokometse tatellano ea methylation ea DNA e tla fetoloa haholo bothateng ba hypersexual. Ho netefatsa bohlokoa ba se fumanoeng, tatellano e ts'oanang ea DNA e ile ea bonts'oa hape hore e fokotsoe ke litaba tse nang le ts'ebeliso ea joala, e fana ka maikutlo a hore e kanna ea amahanngoa haholo le karolo e lemalloang ea lefu la hypersexual. Tsamaiso e khethiloeng ea methylation ea DNA e ne e amahanngoa le microRNA e bitsoang (microRNA 4456; MIR4456), mme tlhahlobo e ngoe e bonts'a hore tatellano ena ea methylation ea DNA e susumetsa bongata ba MIR4456 bo hlahisoang. Ntle le moo, sehlopheng se le seng sa boithuto, re bonts'a hore MIR4456 e na le bongata bo tlase haholo ba ts'oaetso ea hypersexual ha e bapisoa le baithaopi ba phetseng hantle, ba fana ka maikutlo a matla hore liphetoho tsa methylation ea DNA ho ts'oaetso ea ts'oaetso ea hypersexual le eona e kenya letsoho ho hlaloseng tlhekefetso ea MIR4456. Joaloka microRNA: ho latela mohopolo ho khona ho lebisa liphatsa tsa lefutso tse makholo a 'maloa, re sebelisitse li-algorithms tsa khomphutha ho senola hore MIR4456 e shebile liphatsa tsa lefutso tse hlalositsoeng ka ho khetheha bokong le tse amehang mekhoeng e meholo ea limolek'hule tsa methapo ea kutlo tse nkoang li loketse HD, mohlala, oxytocin ho supa tsela. Liphuputso tsa rona li tšoaneloa ke lipatlisiso tse ling ka karolo ea MIR4456 mme haholo-holo Oxytocin ho ts'oaetso ea hypersexual. Ho hlokahala lithuto tse ling ho netefatsa karolo ea Oxytocin ho HD le ho batlisisa hore na kalafo ea kalafo ea lithethefatsi tse loantšanang le oxytocin e ka ba le litlamorao tse ntle ho bakuli ba nang le ts'oaetso ea hypersexual.
Leha ho le joalo lintlha tse sa phatlalatsoang tse etselitsoeng thuto e ikhethileng ea ho latela li bontša keketseho e kholo ea maemo a Oxytocin ho bakuli ba nang le lefu la hypersexual ha ba bapisoa le taolo, le phokotso e kholo maemong a oxytocin kamora kalafo ea Cognitive Behaeve Therapy, e bolelang ka matla karolo e bakang Oxytocin ho lefu la hypersexual le ho etsa hore lipolelo tse hlahisitsoeng thutong ena li be matla le ho feta. Liphetho tsena tsa pele li hlahisitsoe e le poster ea morao-rao kopanong ea Society of Biological Psychiatry ka Mots'eanong 2019 hape e romelletsoe joalo ka poster ho ACNP ka December 2019.
Tlhaloso:
Adrian E. Boström et al, Hypermethylation-e amanang le ho fokotseha hoa microRNA-4456 bothateng ba hypersexual le tšusumetso e matla ho ho saena hoa oxytocin: Tlhahlobo ea methapo ea methapo ea lefutso ea liphatsa tsa lefutso tsa methapo ea methapo. Epigenetics (2019). MOTHE: 10.1080 / 15592294.2019.1656157
;
