TLHAHO: Thuto e ncha ea ho hlahloba boko bapisa taba e tšoeu ea batho ba lemaletseng ho kopanela liphate / ba thobalano (CSBD) le litsamaiso tse tlalehiloeng phapang e kholo lipakeng tsa taolo le lithuto tsa CSB:
Ena ke e 'ngoe ea lithuto tsa pele tsa DTI tse lekolang phapang lipakeng tsa bakuli ba nang le Bothata ba Likhatello tsa Thobalano e Khopisang le taolo e nepahetseng. Tlhahlobo ea rona e senotse phokotso ea FA libakeng tse tšeletseng tsa boko lihloohong tsa CSBD, ha li bapisoa le taolo. Lipampitšana tse khethollang li fumanoe cerebellum (mohlomong ho ne ho e-na le likarolo tsa pampitšana e tšoanang ho cerebellum), karolo ea retrolenticular ea capsule e ka hare, corona radiata e bohareng le taba e tšoeu ea gipus e bohareng kapa ea morao.
Liphetho tsa boithuto ba rona li fana ka maikutlo a hore CSBD e arolelana mokhoa o ts'oanang oa ho se ts'oane le OCD le tahi.
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- 1 Setsi sa Psychology, Setsi sa Mahlale sa Poland, Warsaw, Poland
- 2 Faculty of Psychology, Univesithi ea SWPS ea Saense ea Botho le Botho, Warsaw, Poland
- 3 Laboratori ea ho Nahana ka Boko, Setsi sa Neurobiology, Setsi sa Nencki sa Boithuto ba Biology, Setsi sa Poland sa Saense, Warsaw, Poland
- 4 Setsi sa Patlisiso ea Litšoantšo sa Biomedical, Sedara-Setsi sa Bongaka sa Sinai, Los Angeles, USA
- 5 Setsi sa Swartz sa Computational Neuroscience, Setsi sa Lipalo tsa Neural, Univesithi ea California San Diego, San Diego, USA
inahaneloang
Ka morao le sepheo
Le ha Compulsive Sexual Behaeve Disorder (CSBD) e ekelitsoe ho ICD-11 tlasa sehlopha sa taolo ea tšusumetso ho 2019, ho ntse ho phehisanoa ka mekhoa ea eona ea methapo. Bafuputsi ba hlokometse ho tšoana ha eona le bokhoba ba tahi le Obssesive-Compulsive Disorder (OCD). Morero oa thuto ea rona e ne e le ho araba potso ena ka ho fuputsa mokhoa oa ho senyeha ha boko bo ikhethang ho bakuli ba CSBD.
mekhoa
Ho lekola lingoliloeng tse 39 ho Diffusion Tensor Imaging (DTI) re hlokometse mathata a mantlha a ikhethang bakeng sa lithethefatsi le OCD. Ho feta kamoo re bokelitseng tlhaiso-leseling ea DTI ho tsoa ho banna ba 36 ba bong bo fapaneng ba fumanoeng ba na le CSBD le 31 e tsamaellanang le taolo e nepahetseng. Liphetho tsena li ile tsa bapisoa le bokhoba ba tahi le mekhoa ea OCD.
Results
Ha li bapisoa le taolo, batho ka bomong ba CSBD ba bonts'itse phokotso e kholo ea anisotropy (FA) ea pampiri e phahameng ea corona radiata, pampitšana e ka hare ea capsule, lipampitšana tsa cerebellar le taba e tšoeu ea gipus. Ho khahlisang ke hore libaka tsena kaofela le tsona li fumanoe lithutong tse fetileng e le likamano tse arolelanoeng tsa DTI ho OCD le tahi.
Puisano le liqeto
Liphetho tsa boithuto ba rona li fana ka maikutlo a hore CSBD e arolelana mokhoa o ts'oanang oa ho se ts'oane le OCD le tahi. E le e 'ngoe ea thuto ea pele ea DTI e bapisang phapang ea bokooa lipakeng tsa CSBD, lithethefatsi le OCD, leha e senola likarolo tse ncha tsa CSBD, ha ea lekana ho tseba hore na CSBD e tšoana le tahi e ngata kapa OCD. Liphuputso tse ling, haholo-holo ho bapisa ka kotloloho batho ba nang le mathata ana a mararo li ka fana ka liphetho tse hlakileng.
Selelekela
Compulsive Sexual Behaviors Disorder (CSBD) e hlahisitsoeng ke Mokhatlo oa Lefatše oa Bophelo (WHO) khatisong ea bo11 ea Classification of International Diseases (ICD-11) ke lefu la kelello le khetholloang khafetsa ho hanela litakatso tsa thobalano. Pele, mesebetsi ena e ea putsa bakeng sa mokuli, empa kamora nakoana e ba kotsi ebile e se sebetse, e hlahisang khatello e kholo ea motho. Ho fihlela litekanyetso tsa tlhahlobo ea CSBD, mokuli o tlameha ho bonts'a matšoao a boletsoeng kaholimo bonyane likhoeli tse 6, mme tlhahlobo e ke ke ea etsoa haeba ho se na khatello ea maikutlo bophelong ba motho kapa ha mahlomola a amana feela le kahlolo ea boitšoaro le ho se amohele boitšoaro ba thobalano, hobane mohlala, e ipapisitse le litumelo tsa bolumeli / boitšoaro (Kraus et al., 2018; WHO, 2019). Mekhoa ea CSBD e hlahisitsoeng ke WHO ka bongata e ne e ipapisitse le litekanyetso tsa lefu la hypersexual (HD) le hlahisitsoeng ke Khafetsa (2010) bakeng sa ho hlahlojoa karolong ea mathata a thobalano ea DSM-V. Ka mokhoa o ts'oanang le HD, CSBD e ile ea nkuoa e le khatello ea maikutlo e sa amaneng le takatso ea thobalano e nang le karolo ea ho hloka takatso, e ts'oanang le ho lemalla, leha ho le joalo ho fapana le HD, CSBD tekanyetso ea ho lahla khatello ea maikutlo le taolo ea maikutlo (e ts'oanang le OCD) (bakeng sa puisano e qaqileng bona: Gola et al., 2020).
WHO e khethile CSBD (ho ICD-11) e le ts'oaetso ea taolo ea maikutlo, empa karolo ea ho qobelloa ho kenyeletsoa lebitsong la lefu lena. Ka bomalimabe, sehlopha sa khatello ea taolo ea maikutlo se pharalletse haholo 'me meeli ea sona e ke ke ea hlalosoa ka mokhoa o hlakileng, e leng se etsang hore sehlopha sa CSBD e be taba ea ngangisano e tsoelang pele, e shebaneng le potso ea hore na matšoao a CSBD a na le tšekamelo kapa a qobelloa ho ba teng, kapa hore na CSBD e lokela ho ho e-na le hoo o nkuoe e le pontšo ea ho lemalla boitšoaro Bőthe et al., 2019; Gola et al., 2017; Griffiths, 2016; Kraus, Voon, & Potenza, 2016; Kühn & Gallinat, 2016; Potenza, Gola, Voon, Kor, & Kraus, 2017; Mocha, 2008) kapa mofuta o mong oa lefu la kelello. Ha ba pheha khang ka ho tšoana ha eona le bokhoba ba tahi, hangata bafuputsi ba bua ka mekhoa ea ho khotsofatsa le ho lakatsa thobalano (Ke Tla Tseba Joang 2018; Gola et al., 2017; Klucken, Wehrum-Osinsky, Schweckendiek, Kruse, & Stark, 2016; Kowalewska et al., 2018; Voon et al., 2014), mamello e ntseng e hola le ho hola ha matšoao, joalo ka ts'ebeliso ea lithethefatsi (Reid et al., 2012; Lentsoeecha et al., 2018), Le lefu la ho hula (Garcia & Thibaut, 2010). Ka lehlakoreng le leng, CSBD e boetse e bapisoa le Obsessive-Compulsive Disorder (OCD), kaha e ka bonts'a mehopolo e mebe, e fetelletseng e tsamaeang le litlamorao, ke hore litloaelo, boits'oaro bo pheta-phetoang bo fokotsang tsitsipano e bakoang ke menahano e fetelletseng, e kenelletseng ho thibela kapa fokotsa khatello ea maikutlo kapa matšoenyeho (Modiakone & Abramowitz, 2005; Fineberg et al. 2014). Boitšoaro ba thobalano bo ka bapala karolo ea ho sebetsana le maano a taolo ea maikutlo (Lew-Starowicz, Lewczuk, Nowakowska, Kraus, & Gola, 2020) Ho latela Coleman le basebetsi-'moho (2003), Bakuli ba CSBD ba ba le menahano e pheta-phetoang ea mofuta oa thobalano e bakang tsitsipano (ho hloloheloa maikutlo), mme ba etsa boits'oaro bo qobelloang ba thobalano ho fokotsa tsitsipano ena (Coleman, Raymond, & McBean, 2003). Ka tsela ena, boitšoaro ba thobalano bo ka utloisisoa e le pontšo ea ho qobella (Mick & Hollander, 2006) le boitšoaro ba thobalano bo bapala karolo ea leano la taolo ea maikutlo (Kafka, 2010; Merafo, Dickenson, & Coleman, 2019; Reid & Kafka, 2014). Hajoale mosebetsi ona oa ho sebetsana le mathata ke taba eo ho buisanoang ka eona maemong a CSBD, kaha joale e ne e kenyellelitsoe ho litekanyetso tsa WHO (Gola et al., 2020).
Ho na le bopaki bo ntseng bo hola ba bopaki bo buellang ho ts'oana ha neurobiological lipakeng tsa CSBD le lithethefatsi, mohlala, ts'ebetso e amanang le ts'oaetso ea sistimi ea moputso (bakeng sa tlhahlobo bona: Ke Tla Tseba Joang 2018 or Kowalewska le al., 2018). Tse ling tsa litlamorao tse khahlisang ke:Moetso, Snagowski, Laier, & Maderwald, 2016), kapa li-activations tse kholo kahare ho: dorsolateral prefrontal cortex, caudate, girase e ka tlase ho supramarginal ea parietal lobe, dorsal anterior cingulate cortex le thalamus, bakeng sa maikutlo a ho raela batho ba CSBD ha ba bapisoa le taolo (Seok & Sohn, 2015). Batho ba CSBD ba boetse ba bonts'a ts'ebetso e eketsehileng ea ts'ebetso ea ts'ebetso ea ho tsoaloa (ha e bapisoa le taolo) bakeng sa livideo tse hlakileng tsa thobalano (Voon et al., 2014kapa maikutlo a tsosang takatso empa eseng a lichelete (Gola et al., 2017) le ho fokotsa khokahano e sebetsang lipakeng tsa ventral striatum le prefrontal cortex (Klucken et al., 2016), hammoho le kamano e mpe e mpe lipakeng tsa ho tiea ha matšoao a CSBD le khokahano e sebetsang lipakeng tsa gyrus ea nakoana ea nakoana le mokokotlo o nepahetseng oa caudate (Seok & Sohn, 2018). Mabapi le litlamorao tsa sebopeho sa boko tse amanang le CSBD, Kühn le Gallinat (2014) e fumane kamano e fapaneng lipakeng tsa volumetry e nepahetseng ea caudate le makhetlo a ts'ebeliso ea litšoantšo tsa bootsoa har'a basebelisi ba litšoantšo tse manyala tse hlephisang boitšoaro. Boithuto ba morao-rao bo tsoang sehlopheng sa rona (Draps et al., 2020) e bonts'itse hore batho ba nang le CSBD, bokhoba ba tahi le bothata ba papali ea chelete ba arolelana bophahamo bo bonyenyane ka lehlakoreng le letšehali le ka pele (haholo-holo ho orbitofrontal cortex) ha ba bapisoa le litaba tse phetseng hantle. Lintlha tse boletsoeng ka holimo li tšehetsa khopolo-taba ka ho tšoana pakeng tsa CSBD le lithethefatsi. Ka bomalimabe, ha ho na lithuto tsa neurobiological tse bapisoang le CSBD le OCD.
Mokhoa o mong oa ho ithuta ho tšoana ho teng lipakeng tsa CSBD le ho lemalla lithethefatsi kapa OCD ke ho sheba sebopeho sa 'mele se tšoeu sa boko. Diffusion Tensor Imaging (DTI) ke mokhoa oa ho iketsa litšoantšo oa makenete o mamelang thepa ea lisele tsa microstructural, e lumellang tlhahlobo ea boleng ba lipampitšana tsa litaba tse tšoeu (Basser & Jones, 2002; Guevara, Guevara, Román, & Mangin, 2020; Le Bihan, 2003; Le Bihan et al., 2001). Ho na le mekhoa e mengata ea DTI, ka mohlala mokhoa oa Tract-based Spatial Statistics (TBSSs) o sebelisoang haholo ho lemoha ho se ts'oanehe hoa litaba tse tšoeu bathong (Smith le al., 2006), e shebileng ka kotloloho liphapang tsa karoloana ea anisotropy (FA). Ha ho hlahlojoa TBSS, algorithm ea ngoliso e sa sebetseng e sebelisetsoa ho hlahisa data ka bomong ho palo e emelang ea pampitšana, e bitsoang masapo a bolelang a FA. Re fumane lingoliloeng tse 39 ho OCD (31) le temallo (8) re sebelisa TBSS. Lithutong tsena, bangoli ba bonts'itse liphapang tsa FA lipakeng tsa taolo e felletseng ea 1,050 le bakuli ba baholo ba 1,188 ba fumanoeng ba na le OCD kapa bokuli ba bokhoba. Lihlopha tse nyane haholo tsa bankakarolo ka ho latellana e ne e le:Chumin et al., 2019) le ba robeli sehlopheng sa OCD (Cannistraro et al., 2007). Liphuputso tse mashome a mabeli a metso e robeli li tlalehile liphetho tsa bohlokoa ka P <0.05 kamora ho lokisa bakeng sa lipapiso tse ngata le tse 6 tse sa nepahalang P <0.001, e boholo ba sehlopha sa li-voxels tse 20 kapa ho feta. Mefuta-futa ea libaka e ne e tsebahala haholo ho OCD, mme liphetho li bontša liphapang tse kholo tsa FA lipampitšaneng tse 'maloa tse kang corpus callosum, cingulum bundle, forceps minor le corona radiata. Liphetho li ne li fokola litlamong, ka libaka tse fokolang tse khethollang lipakeng tsa lihlopha tsa bakuli le taolo. Ho khahlisang ke hore libaka tse robong (ke hore, corona radiata e phahameng, capsule ea ka hare, cerebellum, occipital le taba e tšoeu e ka pele, fasciculus e phahameng, posterior thalamic radiata, corpus callosum le thalamus) li senotsoe ha DTI e hokahana ka bobeli, bakeng sa OCD le lithethefatsi (bona Feie. 1).
Liphetho tsa tlhahlobo ea lingoliloeng. Phokotso ea Frisional anisotropy (FA) e khethehileng bakeng sa Bokhoba (buluu), phokotso ea FA e ikhethileng bakeng sa OCD (botala), le libaka tse khethollang bakuli ba lithethefatsi le ba OCD ho tsoa taolong e phetseng hantle (bosehla)
Tlhaloso: Leqephe la Lithethefatsi tsa Boitšoaro JBA 2021; 10.1556/2006.2021.00002
Thutong ea rona re ne re ikemiselitse ho (1) khetholla maemo a FA a ikhethileng bakeng sa OCD le lithethefatsi ka tlhaiso-leseling ea lingoliloeng, (2) ho bokella lintlha tsa DTI ho bakuli ba CSBD le taolo e phetseng hantle (ho sebelisa mokhoa oa TBSS ho khetholla liphapang ho FA), le (3) bapisa liphetho tsa rona ka liphuputso tse tlalehiloeng pejana ho OCD le lithethefatsi, ho khetholla ho tšoana kapa / le phapang lipakeng tsa OCD, lithethefatsi le CSBD.
mekhoa
Boithuto ba DTI
Lihlooho le ho hira
Mohlala ona o ne o e-na le banna ba 67 ba bong bo fapaneng ba arotsoeng ka lihlopha tse peli: bakuli ba 36 CSBD le li-control tsa bophelo bo botle tsa 31 (HCs). Lihlooho li ne li bapisoa le lilemo le lekeno (bona tlhaiso-leseling e batsi ho Lethathamo 1). Lihlooho tsa CSBD li ile tsa hiroa har'a banna ba batlang kalafo litleliniking tsa Warsaw, Poland. Ba ile ba botsoa lipotso ke lingaka tsa mafu a kelello le litsebi tsa kelello ho netefatsa phumano ho latela litekanyetso tsa HD tsa Kafka (Kafka, 2010). Kaofela ba fihletse litekanyetso tse 'ne ho tse hlano tsa A, hape ba phethile litekanyetso tsa B le C (Kafka, 2014). HC e ile ea hiroa ka liphatlalatso tse fumanehang marang-rang, 'me ea se bontše matšoao a kelello le ho phela hantle. Mekhoa ea ho khetholla lihlopha tsena ka bobeli e ne e le nalane ea mathata a mang a kelello, mathata a tebileng a methapo kapa a bongaka, le khanyetso ea lits'ebetso tsa maiketsetso tsa maiketsetso. Barupeluoa bohle ba qetile lipotso tse lekanyang matšoao a CSBD: Teko ea Tlhatlhobo ea Thobalano ea Thobalano (Mofuta oa Sepolishe: SAST-PL-M: Gola et al., 2016) le Screen e Khuts'oane ea Litšoantšo Tsa Bootsoa (Kraus et al., 2020). Nakong ea ho hira barupeluoa le bona ba ile ba hlahlojoa hore na ba batla ho kopanela liphate joang, nalane ea ts'ebeliso e mpe ea joala le mathata a papali ea chelete. Mekhoa ea ho kenyelletsa lihlopha tsena ka bobeli e ne e le: feela kapa boholo ba batho ba bong bo fapaneng ho Kinsey Scale (phetoho ea Poland: Wierzba et al., 2015); lintlha <10 ho Teko ea Boitsebiso ba Ts'oaetso ea Tahi ea Joala (Babor, de la Fuente, Saunders, & Grant, 1989); le lintlha tse <4 ho Screen ea South Oaks ea Papali ea Chelete (Sinchfield, 2002). Barupeluoa ba tšoanelehang ba ile ba mengoa hore ba etele Laborator of Brain Imaging ea Nencki Institute, PAS (Warsaw, Poland) bakeng sa pokello ea lintlha.
Tafole 1.Karolo ea barupeluoa
| CSBD (bolela [sd]); n = 36 | HC (bolela [sd]); n = 31 | P-senolo | |
| Lekhetlo ka lilemo | Ka 31.11 [6.018] | Ka 31.84 [7.142] | NS |
| Teko ea ho hlahloba bokhoba ba thobalano - e ntlafalitsoe | Ka 11.63 [4.664] | Ka 2.67 [1.918] | P <0.001 |
| Setšoantšo se khuts'oane sa litšoantšo tse manyala tse hlephisang boitšoaro | Ka 6 [2.854] | Ka 1.73 [1.929] | P <0.001 |
| Skrine ea papali ea chelete ea oak e ka boroa | Ka 0.33 [0.816] | 0 | NS |
| Teko ea ts'oaetso ea ts'ebeliso ea joala | Ka 7.5 [2.07] | Ka 4 [1.414] | P = 0.013 |
| Lenane la ho shebella-ho qobella-lea ntlafatsoa | Ka 17.18 [10.825] | Ka 13.1 [8.786] | NS |
| Lenane la lipotso tsa khetho ea lichelete - ka kakaretso K boleng | Ka 0.0249 [0.0429] | Ka 0.0307 [0.0481] | NS |
Leano la DTI
Litšoantšo tsohle tsa DTI li ile tsa bokelloa ho skena sa 3-Tesla MRI (Siemens Magnetom Trio TIM, Erlangen, Jeremane) se nang le kela ea hlooho ea mekhahlelo e 12. Ts'ebetso ea Spin-echo diffusion weighted echo planar imaging (DW_EPI) e ile ea etsoa ka mekhahlelo e latelang: TR = 8,300 ms; TE = 87 ms; GRAPPA; phetlhwang 90 °, boholo ba voxel = 2 × 2 × 2 mm3, Litsamaiso tse 64 tsa gradient le b-boleng ba 1,000 s / mm2, hammoho le litšoantšo tse peli tse sa sebeliseng phallo ea phallo (bBohlokoa = 0). Ho latellana ha DW_EPI ho ile ha phetoa ka mekhahlelo e fapaneng ea ho kh'outela anterior-posterior (AP) le posterior-anterior (PA).
Ts'ebetso ea litšoantšo tsa DTI
Litšoantšo tsa DTI li ile tsa sebetsoa ka sephutheloana sa FSL (3.2.0) ho tsoa Laeboraring ea Software ea FMRIB (FSL, www.reobisang.ox.ac.uk/fsl) (Smith le al., 2004). Taba ea mantlha, taelo ea FSL ea fslroi e sebelisitsoe ho ntša litšoantšo tsa b0. Mohato o latelang, data e ile ea etsoa pele ho sebelisoa litokiso bakeng sa ts'ebetso ea ts'oaetso (topup) motheong oa litšoantšo tse peli tsa b0 tse fumanoeng ka likarolo tse fapaneng tsa kh'outu. Lintho tse fumanoeng bakeng sa litaelo tsa AP le PA li kopantsoe ho ba faele e le 'ngoe e mahlakore a mane. Re sebelisa sesebelisoa sa FSL Brain Extraction Tool (bet), li-voxels tsohle tse se nang boko le li-voxels tsohle tse nang le monehelo o monyane feela oa molumo ha li kenyeletsoe setšoantšong sa boholo. Tsamaiso e tloaelehileng le tokiso ea morao-rao e entsoe ka sesebelisoa sa eddy sa FSL. Ho lekana mofuta oa tensor oa diffusion ho voxel e ngoe le e ngoe, litšoantšo tsa FA li ne li baloa ka dtifit.
Phala ea TBSS e ne e na le mehato e latelang e tloaelehileng (Smith le al., 2006Litšoantšo tsa FA tse nkiloeng ke DTI li ne li ngoliselitsoe template. Setšoantšo sa sebaka se tloaelehileng sa FMRIB1_FA se sebelisitsoe e le sepheo ho TBSS. (58) Ka mor'a moo, liphetoho tse se nang moeli tse baloang mohatong o fetileng li sebelisitsoe ho lithuto tsohle ho tlisa lintlha tsa bona sebakeng se tloaelehileng sa 2x1x1 MNI1. (152) Ho boleloa FA le masapo a tsoang lihloohong tse nkang karolo thutong. (3) Ho boloka setšoantšo sa masapo a FA se bolelang boemong ba 4 ho sebelisitsoe ho khetholla litsela tse kholo tsa taba e tšoeu.
Liphuputso tsa Statistical tsa data ea DTI
Bakeng sa TBSS, tlhahlobo e hlakileng ea lineel ea voxelwise e entsoe ho data e felletseng ea boko, ho sebelisoa tumello e sa reroang ea 1,000 ho fumana li-voxels tsa masapo a FA tse nang le phapang e kholo lipakeng tsa taolo e phetseng hantle le sehlopha sa CSBD. Ho sebelisitsoe mofuta oa phapang ea lihlopha tse peli bakeng sa lilemo (e bolelang bohare ba sehlopha). Ha ho li-voxels tse ileng tsa pholoha tokiso ea FDR (sekhahla sa ho sibolla leshano) bakeng sa papiso e mengata. Tlhatlhobo e sa nepahalang e boetse ea etsoa, ka litekanyetso tsa P ho tloha 0.05 ho ea 0.01 le boholo ba sehlopha se seholo> li-voxels tse 50. Lipalo tsa tokiso ea sekhahla sa tšibollo ea bohata (FDR) li ile tsa etsoa ho sebelisoa sengoloa sa Matlab ho tloha Genovese, Lazar, & Nichols, (2002). Libaka tsa phapang e kholo tlasa moeli o sa nepahalang oa P <0.02 e nang le li-voxel tsa 50 e hlahisitsoe ka tlase. Libaka tsa anatomical masapong tse bonts'ang phapang e kholo ea sehlopha ho parameter e fumanoeng ke parameter (e bolelang FA) li ile tsa tsebahatsoa 'me tsa ngoloa ho latela sebopeho se hlalositsoeng ho Atlas (WM) Atlas (Oishi, Faria, Van Zijl, & Mori, 2010). Libaka tseo tsa anatomical li ne li sebelisetsoa ho etsa tlhahlobo ea khokahano le matšoao a lekantsoeng ke Teko ea Tlhatlhobo ea Thobalano ea Thobalano ea Thobalano (Gola et al., 2016) le Screen e Khuts'oane ea Litšoantšo Tsa Bootsoa (Kraus et al., 2020sehlopheng sa CSBD.
Ethics
Tumello ea barupeluoa e nang le tsebo e fumanoe qalong ea thuto. Ho etsa bonnete ba ho se tsejoe, ho ile ha sebelisoa mohato o foufetseng habeli, e le hore litho tsa sehlopha sa lipatlisiso tse ikarabellang bakeng sa ho fumana lintlha tsa DTI li se na monyetla oa ho fumana litlaleho tsa ho hira mme li sa tsebe hore na ho na le motho ea fuoeng karolo ea CSBD kapa sehlopha sa HC. Mekhoa eohle e ile ea etsoa ho latela Phatlalatso ea Helsinki. Phuputso e ile ea amoheloa ke komiti ea melao ea boitšoaro ea lehae ea Setsi sa Psychology, PAS.
Results
Barupeluoa
Lethathamo 1 e na le leseli mabapi le batho ba 36 ba nang le CSBD le li-control tse tšoanang tse 31, bao data ea bona ea DTI e ileng ea hlahlojoa phuputsong ena. Ho ne ho se na phapang lipakeng tsa sehlopha nakong e bolelang. Bakuli ba CSBD ba fumane lintlha tse phahameng haholo sekaleng se lekanyang ho tiea ha CSBD (SAST-R: t = 9.738 P <0.001; BPS: t = 6.623 P<0.001). Bakeng sa bankakarolo bohle, matšoao a lekanyang matšoao a tahi a ne a le ka tlase ho monyako (AUDIT: t = 3.012 P = 0.013, SOGS: t = 0.81 P <0.001). Bakuli ba CSBD ba fumane lintlha tse phahameng haholo ho feta taolo ho Teko ea Boitsebiso ba Tlhekefetso ea Joala (Babor et al., 1989), Empa ha ho le ea mong ea fetang moeli oa ts'ebeliso ea joala (lintlha tse 16). Lihlopha ha lia ka tsa fapana ho Obsessive-Compulsive Inventory-Revised (t = 1.580, P = 0.12; OCI-R, Foa et al., 2002) le Lenane la lipotso la khetho ea lichelete (t = -0.482, P = 0.632; MCQ, Kirby & Marakovic, 1996Ho lekanya ho se ts'oenyehe le ho theola (Marcowski et al., Khatisong).
Liphetho tsa DTI
Re fumane liphapang tse kholo tsa sehlopha lihlopheng tse tšeletseng tsa anatomical (liphetho tsohle ha lia nepahala, 'me litekanyetso tsa tsona li haufi P ho tloha ho 0.05 ho isa ho 0.01 le boholo ba sehlopha se bohlokoa sa bonyane li-voxels tse 50). Ho latela White Matter Atlas (Oishi et al., 2010), lihlopha tsena li na le libaka tse latelang: lipampitšana tse tharo tsa cerebellum, karolo ea retrolenticular ea pampitšana e ka hare ea capsule, karolo e phahameng ea pampiri ea corona radiata le karolo ea taba e tšoeu ea gipus ea occipital (lintlha tse Lethathamo 2 'me Feie. 2). Ho ne ho se na kamano e kholo lipakeng tsa motho ea bolelang FA libakeng tse tšeletseng tsa anatomiki le ho tiea ha matšoao a CSBD, joalo ka ha ho lekantsoe ke Teko ea Tlhatlhobo ea Thobalano ea Thobalano ea Thobalano (Gola et al., 2016) le Screen e Khuts'oane ea Litšoantšo Tsa Bootsoa (Kraus et al., 2020). Sena se ne se sa lebelloa, hobane, ho ea ka lingoliloeng tsa mafu a kelello a joalo ka ho lemalla lithethefatsi le OCD, ho tiea ha matšoao hangata ho amahanngoa le liphapang tsa FA (bakeng sa tahi, bona: Morales, Jones, Harman, Patching-Bunch, & Nagel, 2020; De Santis et al., 2019; le bakeng sa OCD: de Salles Andrade et al., 2019; Fitzgerald, Liu, Reamer, Taylor, le Welsh, 2014; Koch et al., 2012; Saito et al., 2008; Wang et al., 2018; Zhou et al., 2018).
Tafole 2.Liphetho tse tsoang boithuto ba DTI li bapisa bakuli ba 36 CSBD ba nang le taolo e phetseng hantle ea 31
| Index | Saese ea sehlopheng | x | y | z | T-Stat boleng ba tlhoro | P boleng ba tlhoro | Boholo ba phelloa | Tract – lebitso le tsoang Atlas |
| 1 | 61 | 30 | -45 | -28 | 5.3103 | 0.000027776 | 1.290118 | ch, sekhele sa lefatše |
| 2 | 65 | -17 | -49 | -20 | 5.1651 | 0.000046134 | 1.071367 | ch, sekhele sa lefatše |
| 3 | 88 | 24 | -51 | -20 | 5.0823 | 0.000061393 | 1.015533 | ch, sekhele sa lefatše |
| 4 | 64 | 33 | -29 | 6 | 5.1738 | 0.000044763 | 1.125174 | rlic, karolo ea morao-rao ea "capsule" ea kahare |
| 5 | 52 | -40 | -62 | 20 | 4.9949 | 0.000082731 | 1.151454 | O2-WM, bohareng kapa hamorao lateral occipital gyrus taba e tšoeu |
| 6 | 71 | -25 | 14 | 28 | 4.1236 | 0.0013267 | 0.829666 | scr, corona radiata e phahameng |
Cohen's d Boholo ba sephetho bo baliloe e le phapang e bolelang lipakeng tsa lihlopha tse peli tse arotsoeng ka phapano e tloaelehileng e kopaneng.
Phapang lipakeng tsa anisotropy (FA) pakeng tsa bakuli le taolo ea CSBD. Masapo a bolelang a FA lihloohong tsohle a bontšoa a le botala ho feta template ea FMRIB58_FA_1mm. Liphetho li matlafalitsoe ka sepheo sa ho bonts'a pono ho sebelisa taelo e tloaelehileng ea tbss_fill FSL. Lihlopha tse nang le litekanyetso tse phahameng tsa FA (P <0.02, boholo ba lihlopha> 50) sehlopheng sa taolo ha se bapisoa le bakuli ba CSBD se bonts'itsoe ka bofubelu. Ho ne ho se na liphetho tsa bohlokoa bakeng sa phapang e fapaneng (bakuli ba CSBD> sehlopha sa taolo)
Tlhaloso: Leqephe la Lithethefatsi tsa Boitšoaro JBA 2021; 10.1556/2006.2021.00002
Puisano
Ena ke e 'ngoe ea lithuto tsa pele tsa DTI tse lekolang phapang lipakeng tsa bakuli ba nang le Bothata ba Likhatello tsa Thobalano e Khopisang le taolo e nepahetseng. Tlhahlobo ea rona e senotse phokotso ea FA libakeng tse tšeletseng tsa boko lihloohong tsa CSBD, ha li bapisoa le taolo. Lipampitšana tse khethollang li fumanoe cerebellum (mohlomong ho ne ho e-na le likarolo tsa pampitšana e tšoanang ho cerebellum), karolo ea retrolenticular ea capsule e ka hare, corona radiata e bohareng le taba e tšoeu ea gipus e bohareng kapa ea morao.
Ho sheba liphetho tsena maemong a pharalletseng a mathata ohle a kelello le a khatello ea kelello, ho tloha bokhobeng ka ho fetelletseng ho ea ho OCD ho e 'ngoe, re ile ra etsa tlhahlobo e felletseng ea lingoliloeng tsa DTI litsing tse peli tse boletsoeng kaholimo tsa bongaka. Lithuto tse mashome a mararo a metso e robong (tse robeli ka tahi le 31 ho OCD) tse fumanehang ka har'a lingoliloeng li bonts'itse hore, ho latela DTI, ho na le phapang e fokolang ea methapo ea kutlo ho feta OCD. Ho lingoliloeng tsa OCD, sephetho sa mantlha le se tlalehiloeng khafetsa se mabapi le phokotso ea FA libakeng tse joalo ka corpus callosum le cingulum bundle (Benedetti et al., 2013; Bora et al., 2011; Cannistraro et al., 2007; de Salles Andrade et al., 2019; Fan le al., 2016; Gan et al., 2017; Garibotto et al., 2010; Li le al., 2011; Nakamae et al., 2011; Oh le al., 2012; Saito et al., 2008; Spalletta, Piras, Fagioli, Caltagirone, & Piras, 2014; Versace et al., 2019; Yoo et al., 2007; Zhou et al., 2018). Ka lehlakoreng le leng, lingoliloeng tse lemalloang li bua ka posterior corona radiata, capsule e kantle, fornix, insula le hippocampus joalo ka libaka tse khethollang bakuli le taolo ho latela FA (Chumin et al., 2019; De Santis et al., 2019; Pandey et al., 2018; Yip et al., 2017; Zou et al., 2017, hammoho le libaka tse ling tse fumanoang ho OCD, ke hore, corona radiata e phahameng, capsule ea ka hare, cerebellum, taba e tšoeu e ka pele le ea occipital, fasciculus e phahameng, posterior thalamic radiata, corpus callosum le thalamus (Benedetti et al., 2013; Cannistraro et al., 2007; Chumin et al., 2019; Fan le al., 2012; Fontenelle et al., 2011; Gan et al., 2017; Hartmann, Vandborg, Rosenberg, Sørensen, le Videbech, 2016; Kim, Jung, Kim, Jang, & Kwon, 2015; Lochner et al., 2012; Pandey et al., 2018; Segobin et al., 2019; Szeszko et al., 2005; Yip et al., 2017; Yoo et al., 2007; Zhong et al., 2019; Zou et al., 2017). Libaka tse ling tse fumanoang li-sudies tsa OCD li sebakeng se setala ho Lifeiga. 1 le 3 (Glahn, Prell, Grosskreutz, Peschel, & Müller-Vahl, 2015; He et al., 2018; Li, Ji, Li, Li, & Feng, 2014; Menzies et al., 2008; Nakamae et al., 2008; Segobin et al., 2019).
Lintlha tsa rona tsa DTI li bonts'a hore li-neural correlates tsa CSBD lia kopana le libaka tse tlalehiloeng pejana lingoliloeng joalo ka ha li amana ka bobeli, ho lemalla lithethefatsi le OCD (bona sebaka se khubelu ho Feie. 3). Kahoo, thuto ea hajoale e bonts'a ho ts'oana ha bohlokoa lipheong tse arolelanoeng tsa FA lipakeng tsa CSBD le OCD ka bobeli le lithethefatsi. Ka bomalimabe, liphetho tsena ha li bontše hore na ke efe ea mekhatlo ena e 'meli ea bongaka e haufi le CSBD ho latela li-correlates tsa DTI.
Liphetho tse fetang tsa tlhaiso-leseling ea lingoliloeng mabapi le karoloana ea anisotropy (FA) ho Lemallo le OCD, le sephetho sa thuto ea rona ea DTI ho bakuli ba CSBD. Phokotso ea FA e ikhethang bakeng sa Bokhoba (buluu), phokotso ea FA e ikhethileng bakeng sa OCD (botala), libaka tse khethollang bakuli ba lithethefatsi le ba OCD ho tsoa taolong e phetseng hantle (bosehla), le libaka tse khethollang bakuli ba CSBD taolong e phetseng hantle (e khubelu): Lipampitšana tse 3 tsa cerebellum, karolo ea retrolenticular ea pampitšana e ka hare ea capsule, karolo e phahameng ea pampitšana ea corona radiata le karolo ea taba e tšoeu ea gipus ea occipital.
Tlhaloso: Leqephe la Lithethefatsi tsa Boitšoaro JBA 2021; 10.1556/2006.2021.00002
sheba mefokolo ea
Le ha boithuto ba hajoale bo fane ka tlhaiso-leseling e ncha mabapi le phapang ea litaba tse tšoeu ho fapana ha boko ho CSBD, liphetho tsa eona li na le meeli. Phokotso ea mantlha e tloahelehile ho mofuta ona oa boithuto bo amanang, mme e ama taba ea hore phokotso e bonoeng ea phapang molemong oa FA lipakeng tsa mehlala e 'meli e ka ba sesosa se seng se le teng kapa phello ea nts'etsopele ea CSBD. Bothata bona bo ama lithuto tse ling tse ngata tsa phapang ea boko bo sebetsang kapa bo sebetsang bo sebelisa sebopeho sa sefapano (Yuan et al., 2010). Ho hlokahala moralo oa bolelele ba nako ho lekola karolo ea phetoho ea boko joalo ka ha e amana le kholo le khatelo-pele ea matšoao a CSBD.
Thibelo e 'ngoe e amana le ho hiroa ha barupeluoa ba CSBD, e neng e le ka lebaka la Hypersexual Disorder (HD; Kafka, 2010), eseng litekanyetso tsa ICD-11, joalo ka ha lintlha tsa rona li ile tsa bokelloa pele ho lokolloa bukana e ncha ea WHO. Mekhoa e amanang le khatello ea maikutlo le taolo ea maikutlo e teng har'a HD, empa eseng tlhaloso ea CSBD (bona Gola et al., 2020), Ka hona sampole ea rona ea bongaka e kanna ea tšoana le ea batho ba bangata ba OCD. Habohlokoa le ho feta, sampole ea rona e ne e batla e le nyane mme lihlopha tsohle li ne li na le banna ba bong bo fapaneng ba lilemo tse ts'oanang, baahi ba Poland. Lithutong tsa nako e tlang tsa motheo oa neurobiological oa CSBD, ho hlokahala hore ho hiroe mehlala e meholo le e fapaneng haholo. Boholo ba sampole e kanna ea ba lebaka leo ka lona liphetho tsa rona li sa kang tsa pholoha khalemelo ea FWE ea khale, mme ona ke moeli o mong oa thuto. Hape, papiso e tobileng ho batho ba lemaletseng joala le OCD (ho fapana le ho fana feela ka liphetho tse tlalehiloeng lingoliloeng) e kanna ea tšehetsa liqeto tse matla lithutong tse tlang.
Nahanisisa
Liphetho tsa boithuto ba rona li fana ka maikutlo a hore CSBD e arolelana mokhoa o ts'oanang oa ho se ts'oane le OCD le tahi. Ha li bapisoa le taolo, batho ka bomong ba CSBD ba bonts'itse phokotso e kholo ea FA ho pampiri e phahameng ea corona radiata, pampitšana e kahare ea capsule, lipampitšana tsa cerebellar le taba e tšoeu ea gipus. E le e 'ngoe ea thuto ea pele ea DTI e bapisang phapang ea bokooa lipakeng tsa CSBD, lithethefatsi le OCD, leha e senola likarolo tse ncha tsa CSBD, ha ea lekana ho tseba hore na CSBD e tšoana le tahi e ngata kapa OCD. Liphuputso tse ling, haholo-holo ho bapisa batho ka kotloloho ba nang le mathata ana a mararo li ka fana ka liphetho tse hlakileng.
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