Ho feto-fetoha ha likhahla tsa ho kopanya likhahla tsa Cocaine Ho lakatsa ka ho khutsisoa ha se-synapse-Based Remodeling ea Prefrontal Cortex ho Etsa Lihlahisoa (2014)

Lintlha-khōlō Tsa

• Phuputso ena e bonts'a mekhoa e se nang matsoho ea ts'ebetso ea ts'ebeliso ea lithethefatsi

• E bontša moloko o mocha o itšetlehileng ka li-neurocircuits tse ncha ka li-synapses tse khutsitseng

• Liphatlalatso tse peli tsa pele tsa li-cortex-to-accumbens li ntlafatsoa ka mokhoa o fapaneng ke koae

• Mochine oa ho kenella litakatsong tsa koae

Summary

Likhakanyo tsa Glutamatergic tse tsoang ho medial prefrontal cortex (mPFC) ho ea ho li-nucleus accumbens (NAc) li kenya letsoho ho khutliseng k'hok'heine. Mona re bonts'a ntlafatso e khutsitseng e thehiloeng ho synapse ea likhakanyo tse peli tse kholo tsa mPFC-to-NAc li laotse keketseho e tsoelang pele ea k'hok'heine e hlohlellelitsoeng ke cue e batlang kamora ho tlohela. Haholo-holo, ho itaola ha likhoka ka likhoto ho hlahisitse li-synapses tsa AMPA receptor-silent glutamatergic kahare ho infralimbic (IL) le prelimbic mPFC (PrL) ho likhakanyo tsa NAc, tse lekantsoeng kamora letsatsi la 1 la ho khaotsa. Kamora matsatsi a 45 a ho tlohela, li-synapses tse khutsitseng tsa IL-to-NAc ha lia ka tsa emisoa / tsa hola ka ho hira li-AMPs tsa calcium-permeable (CP), athe li-synapses tse khutsitseng tsa PrL-to-NAc li hola ka ho hira bao e seng CP-AMPAR, ho fella ka ntlafatso ea phapang ea tsena likhakanyo. Phetoho ea Optogenetic ea ntlafatso e khutsitseng ea synapse e thehiloeng ho IL-to-NAc le PrL-to-NAc likhakanyo tse ka bang teng 'me tsa thibeloa, ka ho latellana, ho kenella ha takatso ea k'hok'heine ka letsatsi la ho tlohela. boipuso. Liphetho tsena li ka fana ka likaroloana tsa ts'ebeliso ea mekhoa e metle ea ho loants'a ts'oaetso ho fokotsa ts'oaetso ea cocaine.