J Neurosci. 2015 Nov 25; 35 (47):15523-38. doi: 10.1523/JNEUROSCI.2970-15.2015.
Eisenhardt M1, Leixner S1, Lujan R2, Spanagel R3, Bilbao A4.
inahaneloang
Ho kenella ha Glutamatergic ka har'a mesolimbic dopamine (DA) tseleng ho bapala karolo ea bohlokoa ho nts'etsopele ea boitšoaro bo lematsang. Le ha hona ho thehiloe hantle bakeng sa lithethefatsi tse ling tsa tlhekefetso, ha ho tsejoe hore na li-receptors tsa glutamate tse kahare ho sisteme ea mesolimbic li kentse letsoho ho kenella mefuteng ea litheko tsa ts'ebeliso e mpe ea joala.
Mona re sekasekile monehelo oa li-NMDAR tsa li-mMMARAR le AMPAR ho arabella likarabo tse batlang takatso ea joala tse susumetsoang ke ts'usumetso ea tikoloho le boitšoaro bo bocha ka ho sebelisa mela e mene e sa utloahaleng ea "grin1" kapa Gria1 ho li-transporter tsa DA (DDR) kapa D1R. Pele re bonts'a ho haella ha GluN1 kapa GluA1 ebang ke li-neurons tse hlahisang letsatsi la DAT- kapa la D1R melaong ea rona ea panya ka lithuto tsa colocalization. Joale re bonts'a hore li-receptor tsa GluN1 le GluA1 li kena kahare ho litlhaloso tsena tsa neuronal li buella phello ea tlhekefetso ea joala, ha e sa na le tšusumetso ho kenyelletsong ea boitšoaro le tlatsetso ea cue-e khothalletsang ts'ebetso ea ho ts'oara joala. Re netefalitse liphetho tsena ka ho bonts'a phokotso e tšoanang kamora phello ea tlhekefetso ea joala kamora ho kenella hoa memelo ea mohanyetsi oa NMDAR sebakeng sa li-nucleus tse bokellaneng le sebaka sa phetoho ea litoeba tsa taolo, le pholoso ea phenotype e teng ka tšebeliso ea meriana ea ts'ebetso ea AMPAR e sebelisa aniracetam. Iphetho, li-neurop tsa dopamine hammoho le li-neuron tsa D1R tse hlalosang mantsoe a mahareng a bohareng le lipallo tsa tsona tsa glutamatergic ka li-NMDARs le AMPAR li etsa konkreite ho susumetsa likarabo. Liphetho tsena li fana ka suburoate ea neuroanatomical le molek'hule bakeng sa boits'oaro bo bocha hape e hatisa bohlokoa ba lithethefatsi tsa glutamatergic ho fetoheng boits'oaro.
TLHALOSO EA SIGNIFICANCE:
Mona re fana ka bopaki ba liphatsa tsa lefutso le tsa bongaka ba hore li-glutamate receptors tse kahare ho sisteme ea mesolimbic dopamine li bapala karolo ea bohlokoa ho khutliseng joala. Re sebelisa mefuta e fapa-fapaneng e sa sebetseng le e ikhethang ea "transgenic mouse" le liteko tsa tlhahlobo ea meriana, re bontša hore li-subunits tsa NMDAR le li-AMPAR tse hlahisitsoeng e le li-neurop tsa dopamine kapa li-dopamine receptor D1 tse nang le karolo ea bohlokoa phelisong ea tlhekefetso ea joala (keketseho ea tšebeliso ea joala kamora nako ea ho itlopa joala) ha e sa na tšusumetso ho tlatselletso ea karabo e kopantsoeng le cue e khothalelitseng likarabo tse batloang ke joala. Litlhare tse lebisang glutamatergic neurotransication ka ho khetha ka mokhoa o ikhethileng oa li-receptor tsena tsa glutamate li ka ba le katleho e kholo ea kalafo.
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