Li-neuron tsa Glutamatergic li-mediate-cortex li arolelana ho thehoa le ho khutlisetsoa ha likhopolo tse amanang le k'hok'heine liketsong (2019)

Ho lemalla Moferefere. 2019 Feb 7. doi: 10.1111 / adb.12723.

Zhang T.1, Yanagida J1, Kami H1,2, Setšoantšo sa Wada S1, Domoto M1, Sasase H1, Deyama S1, Takarada T.1,3, Hinoi E1, Sakimura K4, Yamanaka A.5, Maejima T.6, Mieda M6, Sakurai T6,7, Nishitani N8, Nagayasu K8, Kaneko S8, Minami M2, Kaneda K1.

inahaneloang

Bokhobeng ba lithethefatsi, tšusumetso ea tikoloho e neng e amana le tšebeliso ea koae ka mokhoa o hlakileng e amanang le koae, e phehellang nako e telele kamora ho khaotsa le ho tsibatsa takatso ea koae. Leha lithuto tse fetileng li bontša hore medial preambilial cortex (mPFC) e ameha ho hlahiseng mekhoa ea bokhoba ba koae, e ntse e sa hlake hore na li-neurons tse thobang le tse thibelang mPFC li amana ka nepo le ho bopa lintho tse amanang le koae. Ho sebetsana le bothata bona, re sebelisitse theknoloji ea li-receptors e ntlafalitsoeng feela ke lithethefatsi tsa moqapi (DREADD) tse kopantsoeng le paracigm ea cocaine e nang le maemo a kopanetseng. Re hatelletse ts'ebetso ea methapo ea MPFC ka mokhoa o amanang le sele le ho latela nako. C57BL / 6J litoeba tsa mofuta o hlaha li fumane ho kenella ka har'a kokoana-hloko e amanang le adeno (AAV) e hlalosang inhibitory DREADD (hM4Di) tlasa taolo ea mofani oa CaMKII ho hatella ka bohona mPFC neurons neurons. Litoeba tsa GAD67-Cre li ile tsa fumana infusions e kenang ka hare ho naha ea mPFC ea AAV e its'epahalleng ha e bua ka HM4Di hore e khutsise ka ho khetheha methapo ea kutlo ea GABAergic. Khatello ea Chemogenetic ea li-neuron tsa mPFC tsa phiramide e hatisitse haholo ho fumana le ho buoa ha koae ea CPP, ha khatello ea methapo ea kutlo ea MPFC GABAergic e sa ama ho fumana kapa polelo ea CPP ea koae. Ho feta moo, thibelo ea chemogenetic ea mPFC glutamatergic neurons ha e-ea ama ho nkuoa le polelo ea lithium chloride-e susumetsoang ke boemo ba ho hloea. Liphetho tsena li fana ka maikutlo a hore ts'ebetso ea ts'ebetso ea glutamatergic, empa eseng GABAergic, li-neuron tse ho mPFC li pakeng ka ho theha le ho khutlisa mehopolo e amanang le koae.

LIHLOOHO TSE TSOANG PELE: TSOHLE; temallo; koae; glutamate; medial preortal cortex; memori

PMID: 30734456

DOI: 10.1111 / adb.12723