Phekolo ea Morphine e ntlafatsa phallo ea glutamatergic ho li-neurons tsa nucleus accumbens ka bobeli bo bakoang ke li-disinhibitory le stimulating effect (2016)

Ho lemalla Moferefere. 2016 Aug 22. Doi: 10.1111 / adb.12438.

Yuan K1, Sheng H1, Sefela J1, Yang L1, Cui D.1, Mme Q1, Zhang W1, Lai B1, Chen M1, Zheng P.1.

inahaneloang

Ho lemalla lithethefatsi ke bokuli bo sa foleng bo khetholloang ka tšebeliso e thata ea lithethefatsi. Matla a matlafatsang a tšebeliso ea lithethefatsi khafetsa moputsong a bapala karolo ea bohlokoa boits'oarong bo khothalletsoang ke morphine. Li-nucleus accumbens (NAc) ke sebaka sa bohlokoa moo kalafo ea morphine e hlahisang phello ea eona e matlafatsang moputsong. Leha ho le joalo, hore na kalafo ea morphine e hlahisa litholoana tsa eona tse matlafatsang ho moputso joang ho NAc e ntse e tlameha ho hlakisoa. Thutong ea hona joale, re ithutile tšusumetso ea kalafo ea morphine litlamorao tsa DA mme ra bona hore na kalafo ea morphine e ka fetola ka ho toba phetiso ea glutamatergic synaptic ho NAc. Re boetse re ithutile bohlokoa ba tšebetso ba phetisetso ea morphine-e susumetsang ea phetisetso ea glutamatergic synaptic ho NAc maemong a boitšoaro. Liphetho tsa rona li bonts'a hore kalafo ea morphine (1) morphine e tlosa phello ea thibelo ea DA ho kenngoeng ha glutamatergic ho li-neuron tsa NAc; (2) kalafo ea morphine e tlatsetsang ho kenngoa ha glutamatergic ho li-neuron tsa NAc, haholo-holo e tsoang ho basolateral amygdala (BLA) ho ea NAc; (3) blockade ea phetisetso ea glutamatergic synaptic ho NAc kapa ho tlosoa ha li-neuron tsa projeke ho tloha BLA ho NAc haholo ho fokotseha keketseho ea kalafo ea morphine e hlahisoang ke ts'ebetso ea locomotor. Liphetho tsena li bontša hore kalafo ea morphine e ntlafatsa ho kenella ha glutamatergic ho li-neuron tsa NAc ka bobeli ka disinhibitory le phello e susumetsang mme ka hona e eketsa ts'ebetso ea locomotor.