J Neurosci. 2019 Apr 4. pii: 3020-17. Doi: 10.1523 / JNEUROSCI.3020-17.2019.
Benneyworth MA1,2, O utloang ke MC3, Asp AJ1, Madayag A3, Ingebretson AE1, Schmidt CE1, Silvis KA1, Larson EB1, Ebner SR1, Thomas MJ4.
inahaneloang
Ho utloisisa lits'ebetso tsa neurobiological tse tsosang takatso ea lithethefatsi le ho oela hape ho na le monyetla oa ho thusa ho tobisa boiteko ba ho phekola bokhoba ba tahi. Li-nucleus accumbens (NAc) li sebetsa e le karoloana ea bohlokoa bakeng sa moputso le boits'oaro bo susumetsang, ka karolo e 'ngoe ka lebaka la liphetoho lipakeng tsa matla a kopaneng a synaptic ka har'a litsela tsa cortical-accumbens. Boithuto bo teng hona joale bo fuputse khokahano ea mabaka pakeng tsa cocaine e kenyellelitseng boikhethelo ba sebaka se khethiloeng le phokotso e potlakileng ea keketseho e itšetlehileng ka koae ho matla a NAc a synaptic ho litoeba tsa banna. Cocaine e nang le maemo a sebaka a ratang ho khetha le Ex vivo Electrophysiology ea sele e felletseng e bonts'itse hore ho khutlisetsoa ha koae-primed le ho fokotsoa ha methapo ea kutlo ho ferekantsoe ke ho thibela ts'ebetso ea AMPAR ka ho kenella ka har'a intra-NAc shell ka infra-GluA23Y peptide. Ho feta moo, ho khutlisetsoa morao ho ne ho tsamaisoa ke phokotso e itšetlehileng ka mGluR5 ea ho saena hoa AMPAR. Ho kenella ka hare ho karolelano ea khetla ea intra-NAc ea mGluR5 antagonist MTEP e koetsoe ho khutlisetsa koae-primed le ho tsamaisoa ha nako e tšoanang, ha infusions ea mGluR5 agonist CHPG ka boeona e khothalelitse ho khutlisoa le matla a kopaneng a synaptic ka har'a khetla ea NAc. Tlhahlobo ea Optogenetic ea potoloho e ikhethang ea potoloho e bontšitse hore thibelo ea ts'ebetso ea infralimbic cortical polokelong ea NAc e koetsoe ho ts'oaroa ha cocaine-primed, ha mokhoa o tlase oa ts'usumetso (10 Hz) ea tsela ena ka lebaka la ho hloka cocaine e bakile phokotso ea matla a synaptic joalo ka ha a hlokometse le cocaine, 'me e ne e lekane ho khothaletsa ho khutlisetsoa bothateng ha ho se na phephetso ea koae. Lintlha tsena li tšehetsa mohlala oo ho oona phokotso ea mGluR5-Mediated ho GluA2-e nang le AMPARs ho NAc shell synapses e fumanang mohopolo ho tsoa ho infralimbic cortex ke ntlha ea bohlokoa ea ho etsa hore o khutlisetsoe tseleng ea ts'ebeliso ea koae.TLHOKOMELISO SIGNIFICANCELithuto tsena li bonts'a tatellano ea liketsahalo tsa neural moo ho pepesehelang k'hok'heine ho ts'oarang komporo e tšoaeang matla a synaptic bokong mme e baka karabelo ea boitšoaro e hlahisoang ke mohopolo o amanang le lithethefatsi.
PMID: 30948476
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