Yin le yang ea ho hlōla ho lemala ha cocaine (2014)

Yin le yang ea ho hlola temallo ea koae

letsatsi:
September 4, 2014
Source:
Univesithi ea Pittsburgh

Yaoying Ma o re biology, ka tlhaho, e na le yin le yang - sututsa le ho hula.

O fumana hore ke temallo, haholo-holo ha a khutlela morao.

Ma ke setsebi sa lipatlisiso lefapheng la Yan Dong, motlatsi oa moprofesa oa thuto ea methapo ea kutlo Univesithing ea Pittsburgh ea Kenneth P. Dietrich Sekolo sa Bonono le Saense. Ke eena mongoli ea ka sehloohong oa pampiri e phatlalalitsoeng inthaneteng kajeno koranteng Neuron e fanang ka maikutlo a hore e ka ba monyetla oa ho nyolla karabelo e kenelletsang e khahlanong le bokhoba e le mokhoa oa ho loants'oa ke koae hape le ho thibela liphiri tsa ho oela hape.

Pampiri ena ke ea pele e netefatsang boteng ba litsamaiso tsa boko tse hananang le ts'ebeliso e mpe ea ts'ebeliso ea k'hok'heine ka tlhaiso-leseling ea methapo ea tlhaho e nang le "li-synapses tse khutsitseng."

Mosebetsi ona ke oa ho latela tlhahlobo ea morao-rao e entsoeng ke Dong le basebetsi-'moho le eena, e phatlalalitsoeng ka Nature Neuroscience Pulungoana e fetileng. Sehlopha se sebelisitse mefuta ea likhoto ho lekola litlamorao tsa ts'ebeliso ea "cocaine" le ho hula lisele tsa methapo "nucleus accumbens", sebaka se senyane bokong se atisang ho amahanngoa le moputso, maikutlo, tšusumetso le bokhoba. Haholo-holo, ba batlisitse likarolo tsa li-synapses - likarolo tse lipheletsong tsa lisele tsa methapo tse fetisang matšoao.

Sehlopha se tlaleha ho sona Nature Neuroscience ithute hore ha rat e sebelisa k'hok'heine, ho hlahisoa li-synapses tse sa hōleng kapele, tse bitsoang "li-synapses tse khutsitseng" hobane ha li sebetse ebile li romella matšoao a fokolang tlasa maemo a tloaelehileng a mmele. Kamora hore rat e khaotse ho sebelisa k'hok'heine, "li-synapse" tsena tse khutsitseng li feta mohatong oa ho butsoa ebe li sebetsa ka botlalo ho romella lipontšo. Hang ha ba ka romella lipontšo, li-synapses li tla romella matšoao a takatso ea k'hok'heine haeba rat e ka pepesetsoa likhakanyo tse neng li amana le sethethefatsi.

Ea hajoale Neuron pampiri e bontša hore ho na le lehlakore le leng la "ntlafatso ea" synapse "e nchafatsoang. Li-synapses tse khutsitseng tse hlahisoang ka har'a projeke e itseng ea "cortical proaction" ea "nucleus" e fumanoang ke "cocaine" e fetoha "unsilenced" kamora ho tlohela k'hok'heine, e leng se hlahisang phetoho e kholo ea projeke ena ea cortical. Liteko tse ling li bonts'a hore ntlafatso e thehiloeng ka lenyele ea synapse ena ea cortical e fokotsa takatso ea k'hok'heine. Habohlokoa, ntlafatso ea potoloho ea potoloho e khahlano le ho oela hape e bakoa ke ho pepeseha ha cocaine ka bo eona, ho fana ka maikutlo a hore 'mele ea rona e na le tsela ea eona ea ho loants'a bokhoba ba tahi.

Dong, sengoli se phahameng sa pampiri, o re karabelo ea pro-relapse e bohlokoa haholo kamora ho pepeseha ha cocaine. Empa kaha karabelo e khahlano le ho khutlela mokhoeng e teng kahare ho boko, e kanna ea tlamelloa ka bongaka ho fihlela melemo ea kalafo.

Ma o re ho sibolloa hona "ho ka fana ka leseli la litsela tsa ho sebelisa tekano ea yin-yang mme ka ts'epo ho fana ka lipheo tse ncha tsa methapo ea kutlo bakeng sa mehato e reretsoeng ho fokotsa ho khutla hape."

"Pale e ke ke ea emisa mona," Ma oa eketsa. "Phuputso ea rona e ntseng e tsoela pele e ntse e hlahloba mekhoa e meng e sa tloaelehang empa e le bonolo ea ho ntlafatsa mokhoa ona oa ho loantša ho oela hape."

Mohloli oa pale:

Pale e kaholimo e thehiloe ho thepa fanoeng ke Univesithi ea Pittsburgh. Tlhokomeliso: Lisebelisoa li ka hlophisetsoa bakeng sa litaba le bolelele.

Journal Reference:

  1. Yao-Ying Ma et al. Ho fetohela ha maikutlo a Bidirectional ea Incubation ea Cocaine Craving ka Silent Synfall-based Remodeling of Prefrontal Cortex to Accumbens Projections. Neuron, Loetse 2014 Doi: 10.1016 / j.neuron.2014.08.023