Resin ea Boko. 2013 Dec 6;1541:22-32. doi: 10.1016/j.brainres.2013.10.015.
Garduño-Gutiérrez R1, Lelea-Olea M, Rodríguez-Manzo G.
inahaneloang
Li-receptor tsa opioid li ikhula kahare ho ts'usumetso e khethehileng ea agonist. Bohlokoa ba vivo ba receptor Internalization ha bo thehiloe hantle, karolo e le ka lebaka la meeli ea vivo e sebelisitsoeng ho ithuta taba ena. Ejaculation e phahamisa tokollo ea endio native opioid receptors bokong, ho kenyelletsa tsamaiso ea mesolimbic le sebaka sa medial preoptic. Morero oa mosebetsi o teng e ne e le ho sekaseka hore na ho na le khokahano lipakeng tsa degree ea vivo mu (MOR) le delta opioid receptor (DOR) kahare sebakeng se phethoang ka sepheo sa ts'ebetso le ts'ebetso ea lipalo tse fapaneng tsa boipelaetso ba litoeba tsa banna. Bakeng sa sepheo sena, re ile ra sekaseka likotoana tsa litoeba tse tsoang hanngoe kapa ka makhetlo a tšeletseng a latellanang le likhoto tse felisitsoeng ka thobalano tse nang le tšitiso ea thobalano, re sebelisa immunofluorescence le microscopy ea sephiri.
Liphetho li bonts'itse hore boits'oaro ba MOR le DOR bo eketsehile ka lebaka la ho phunyoloha.
Ho ne ho na le kamano lipakeng tsa palo ea thobalano e bolailoeng le tekanyo ea ho kenella kahare ho MOR, empa eseng bakeng sa DOR. HO TSUA ka hare ho nama ho ne ho le kholo ho likhoto tse tsoang khafetsa ho feta liphoofolong tse neng li hula hanngoe feela. Bohlokoa bo kahare ba DOR bo fumanoe feela ho liphoofolo tse jang hang. Liphetoho tsa ho hlahlojoa ha MOR, DOR le betaXinUMX, tse amanang le ts'ebetso ea thobalano, le tsona li fumanoe. Ho khothalletsoa hore ho kopitsoa ka satiety ho ka ba molemo joalo ka mokhoa oa mohlala ho ithuta bohlokoa ba tlhaho ea ho amohela li-receptor.
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