Li-receptor tsa Dopamine li phetha karolo e ikhethang tabeng ea boitšoaro bo bobe ba ho kopanela liphate le lits'ebeletso tse fapaneng tsa ho kopanela liphate (2014)

Behav Pharmacol. 2014 Oct;25(7):684-94. doi: 10.1097 / FBP.0000000000000086.

Guadarrama-Bazante IL1, Canseco-Alba A, Rodríguez-Manzo G.

inahaneloang

Dopamine (DA) e bapala karolo ea mantlha pontšong ea boitšoaro ba monna ba thobalano. Litlamorao tsa lithethefatsi tse matlafatsang tsa DA ho kopi li bonahala li fapana ho latela tekanyetso ea agonist e sebelisitsoeng, mofuta oa receptor oa DA o sebetse le boemo ba thobalano ba liphoofolo. Morero oa thuto ea morao-rao e ne e le ho etsa tlhahlobo e hlophisehileng ea litlamorao tsa dopaminergic agonists ponts'ong ea boitšoaro ba monna ka likamano tsa botona le botšehali lithutong tse fapaneng tsa thobalano, e leng ha ho kopanela liphate (ho ba le thobalano) le ha ho thibetsoe ka nakoana ( felile ka thobalano). Ho fihlela sena, litekanyetso tse tšoanang tsa litheko tse mpe tsa DA tsa receptor agonist apomorphine, D2-like DA receptor agonist quinpirole, le D1-like DA receptor agonist SKF38393 li kentsoe ka mokhoa o ikhethileng litabeng tsa banna tse nang le thobalano kapa tsa thobalano. e tlalehiloe. Tekanyetso e tlase ea apomorphine e kenyelitse polelo ea boitšoaro ba thobalano ho litoeba tse nang le thobalano, empa e fokolitse feela ho kenella ho likhoto tse nang le thobalano. SKF38393 e nolofalitse polelo ea boitšoaro ba thobalano ka likhoto tse felileng ka thobalano, empa eseng joalo ka banna ba nang le boiphihlelo ba thobalano le quinpirole ha e hlahise phello mefuteng ka bobeli ea phoofolo. Tumellanong le liphetho tsena, phetoho e matla ea apomorphine e bakiloeng ke ho hlonepha ka thobalano e thibetsoe ke SCH1 ea D23390-like receptor antagonist. Lintlha li fana ka maikutlo a hore li-receptors tsa DA li bapala karolo tse ikhethang ho bonts'a boitšoaro ba thobalano ke likhoto tsa banna ho latela maemo a bona a ts'usumetso le hore ts'ebetso ea li-receptors tse kang D1 e khothaletsa polelo ea boitšoaro ba thobalano ho likhoto tse satiated.