Kamano pakeng tsa ho ba le bothata ba ho kopanela liphate le bokooa Androgen Receptors (2007)

Litlhaloso: Phuputso e entsoeng morao tjena e tiisa hore androgen e fumanoa ka lipalo tse ntseng li khathala. Phuputso e fumane li-receptors tse khutlelang ho tloaelehileng ka lihora tsa 72, empa potency e feletseng ea thobalano e nka matsatsi a 15 ho khutlela ka botlalo. Lintlha tse ling li tlameha ho ameha ho thibela ho kopanela liphate boitšoaro ba thobalano matsatsing a 15


Romano-Torres M, Phillips-Farfán BV, Chavira R, Rodríguez-Manzo G, Fernández-Guasti A.

Neuroendocrinology. 2007; 85 (1): 16-26. Epub 2007 Jan 8.

Lefapha la Pharmacobiology, Centro de Investigación y Estudios Avanzados, Mexico City, Mexico.

HO HLOKA

Morao tjena re bontšitse hore 24 h ka mor'a ho kopanya li-satiety, ho na le ho fokotseha ha methapo ea li-androgen (ARS) sebakeng sa lipakeng tsa pele-pele (MPOA) le mokokotlong oa tlhaho oa motlakase (VMH), empa eseng ka lehare la bethe la stria terminalis (BST).

Thuto ea hona joale e etselitsoe ho hlahloba hore na li-ARD li fetoha libakeng tsena le tse ling tsa boko, tse kang amygdala (MeA) le kamore ea lateral, karolo ea ventral (LSV), e amahanngoa le liphetoho boitšoarong ba thobalano ka mor'a ho etsa thobalano.

Litoeba tsa banna li ne li etsoa sehlabelo 48 h, 72 h kapa matsatsi a 7 ka mor'a ho kopanela liphate (4 h ad libitum copulation) ho fumana ARD ka immunocytochemistry; Ho phaella moo, litekanyetso tsa testosterone serum li ne li lekanngoa lihlopheng tse ikemetseng tse nyeheloang ka nako e le 'ngoe. Ketsahalong e 'ngoe, banna ba ile ba lekoa hore ba hlaphoheloe boitšoarong ba thobalano 48 h, 72 h kapa matsatsi a 7 ka mor'a ho kopanela liphate. Liphetho li bontšitse hore 48 h ka mor'a ho ba le takatso ea ho kopanela liphate 30% ea bashanyana e bontšitse ejaculation e le 'ngoe' me karolo e setseng ea 70% e bontšitse ho thibela ka ho feletseng boitšoaro ba ho kopanela liphate.

Phokotso ena ea boitšoaro bo bobe ba thobalano e ne e tsamaea le ho fokotseha ha li-AR ha feela karolong ea lipompo ea MPOA (MPOM). Lihora tse mashome a supileng a metso e 'meli ka mor'a ho kopanela liphate ho ts'oanela ho kopanela liphate ho e-na le ho hlaphoheloa ha thobalano ho feletsoe ke keketseho ho ARd ho laola maemo a MPOM le ho feteletsa maikutlo ho feta ho ARS LSV, BST, VMH le MeA.

Litekanyetso tsa tesumsterone tsa serum li ne li sa ts'oaroe nakong ea nako e tlang. Liphello li tšohloa motheong oa ho tšoana le ho se lumellane pakeng tsa li-AR ho libakeng tse itseng tsa boko le boitšoaro ba banna ba thobalano.