Ho tlohella pele, ho qobella motho le ho lemala: menehelo ea seminete ea Dr. Athina Markou ho susumetsa ho senya ho lemalla (2015)

Psychopharmacology (Berl). 2017 Jan 3. doi: 10.1007 / s00213-016-4484-6.

Koob GF1.

inahaneloang

TLHOKOMELISO LE LITLHAKISO:

Ho lemalla ho hlalosoa e le bothata bo sa foleng ba bocha bo khetholloang ka ho batla lithethefatsi tse matla tse khothalletsoang ho tsoa mehloling e mengata ea tahlehelo ea maikutlo.

Mekhoa le Liphello:

Ngaka Athina Markou o ile a kenya letsoho ho thusa ho utloisisa kutloisiso ea methapo ea kutlo le lithuto tsa hae mabapi le taolo ea ts'ebetso ea moputso a sebelisa mehlala ea liphoofolo. Ho pheta-pheta ho eketsehileng hoa lits'ebetso tsa moputso ka lithethefatsi tsa tlhekefetso ho fokotseha ts'ebetso ea moputso, e khetholloang ka moputso oa ts'usumetso ea boko le ho bonahatsa ka mokhoa o hlakileng boemo ba dysphoria. Moralo oa ntlafatso e mpe, o hlalosoang e le tšebeliso ea lithethefatsi e fokotsang moea o seng monate oa maikutlo o thehiloeng ke ho tlohela lithethefatsi, o bohlokoa haholo joalo ka tšusumetso mehatong ea bobeli ea ho tlosa / e sa ameheng le ea ho lebella / mehato ea ho lebella ea ts'ebetso ea ts'ebetso ea tlhekefetso.

CONCLUSIONS:

Boemo bo bobe ba maikutlo bo etsang hore ts'ebetso e joalo e mpe e matlafatsoe ho tsoa tšebetsong ea methapo ea methapo ea methapo e tsamaisang ts'usumetso / menyetla ea moputso (dopamine, li-peptide tsa opioid) ka har'a ventral striatum le ho hira lits'ebetso tsa khatello ea kelello (corticotropin-releasing factor, dynorphin) ka har'a amygdala e atolositsoeng. Ha tšebeliso ea lithethefatsi e fetoha tse qobelloang, lintlha tse susumetsang boitšoaro li susumetsoa hore li fetohele mekhoeng ea ho batla lithethefatsi e sa khannoang feela ka ts'usumetso e ntle empa hape le ka ts'usumetso e mpe. Phetoho ena e susumetsoa ke ho bonts'a ho se utloisisehe hantle hoa molumo oa hedonic hoo ho nka lithethefatsi ho etsang hore maikutlo a mabe a maikutlo a mabe a mpe a be mabe haholo nakong ea ho batla phomolo ea nakoana ka ts'ebeliso e qobelloang ea lithethefatsi.

LINKOTSO: Tlatsetso; Moputso oa ho hlohlelletsa Brain; Corticotropin-lokolla ntho; Boikokobetso; Ts'ebeliso e Mpe ea Lithethefatsi; Dynorphin; Intracranial le ho itlhasimolla; Matlafatso ea matla

PMID: 28050629

DOI: 10.1007/s00213-016-4484-6