Ho tlosoa ha Cocaine ho eketsa menyetla ea nako e telele e bakoang ke motsoako oa corticotropin-ho lokolla ka har'a methapo ea macutamatergic ka li-CRF, li-receptors tsa NMDA le PKA (2006)

Eur J Neurosci. 2006 Sep;24(6):1733-43.

Poland S1, Liu J, Orozco-Cabal L, Grigoriadis DE, Vale WW, Gallagher JP, Shinnick-Gallagher, P.

inahaneloang

Bokhoba ba Cocaine ke bothata bo tšoarellang, bo khutlang hape, ba boits'oaro boo khatello ea maikutlo e khutlisetsang ho batla koae le ka mor'a ho ithiba nako e telele. Bopaki bo fana ka maikutlo a hore boits'oaro bo joalo ka 'matšoenyeho' le khatello ea maikutlo tse amanang le ho hula nako e telele li ka kenella ka lebaka la keketseho ea corticotropin-releasing factor (CRF) bohareng ba amygdala (CeA), karolo ea li-circus tsa limbic tse kenang ho kh'outeng le phetiso ea mekhatlo ea moputso. Thutong ea hajoale re hlalosa monyetla o tšoarellang oa phetisetso ea glutamatergic e hlohlellelitsoeng ho lateral amygdala (LA) -to-CeA synapses ka rat / CRF ea motho. Kamora libeke tsa 2 tsa ho khaotsa ho ts'oaroa khafetsa khafetsa ho cocaine, CRF-induction ea nako e telele ea ts'ebetso (LTP) e ile ea matlafatsoa haholo ha e bapisoa le sehlopha se fapaneng sa taolo ea saline ha, kamora ho khaola ha nakoana (24 h), ho ne ho se na phapang e kholo lipakeng tsa lihlopha tsena tse peli tsa kalafo, e bonts'ang liphetoho lits'ebetsong tsa CRF nakong ea ho khaotsa ho matla ho koahelang koae. Kamora ho khaotsa ka nako e telele, CRF e hlohlellelitsoeng ke CRF e ne e its'etleha ts'ebetsong ea CRF2, CaV2.3 (R-mofuta) liteishene tsa khalsiamo le ho saena lipakeng ka protheine kinase C ka lihlopha tse tšoaroang ke koae. Lenaneo le ntlafalitsoeng la CRF le kenyellelitsoeng kamora libeke tsa 2 tsa ho tlosa le kopantsoe ka tšebetso e amohelang CRF1 receptor, e amanang le ho eketseha ha matšoao ka protheine kinase A, le li-receptor tsa N-methyl-D-aspartate (NMDA). Ka hona, lirekoto tsa sele e le 'ngoe li senotse keketseho e kholo ea NMDA / AMPA kamora ho khaotsa ka nako e telele kalafong ea koae. Liphetho tsena li tšehetsa karolo ea CRF1 antagonists e le likhetho tsa kalafo tse hlakileng nakong ea ho khaotsa koae e sa foleng mme ba fana ka tlhahiso ea Ca (V) 2.3 blockers e le bao e ka bang likhetho bakeng sa phetisetso ea meriana ea li-system tsa CRF.

PMID: 17004937

DOI: 10.1111 / j.1460-9568.2006.05049.x