Corticotropin e lokollang mofuta oa mofuta oa 2 receptor le corticotropin e lokollang protheine e tlamang e sebetsang sebakeng sa rat ventral tegmental sebakeng sa methapo ea methapo e hlahang sebakeng sa lateral hypothalamic (2015)

Eur J Neurosci. 2015 Oct 27. Doi: 10.1111 / ejn.13113.

Slater PG1, Noches V1, Gysling K1.

inahaneloang

Ho na le bopaki ba bohlokoa bo sebetsang bo bonts'ang hore corticotropin release factor factor-2 receptor (CRF)2 R) le corticotropin e lokollang liprotheine tse tlamang (CRF-BP) li laola li-synapses tsa glutamatergic sebakeng se bitsoang ventral tegmental area dopaminergic neurons. It e bonts'itsoe hore CRF e hloka CRF-BP ho li-receptor tsa N-methyl-D-aspartate tse nang le bokhoni ba dopaminergic neurons ka CRF2 R, mme seo se eketsa tokollo ea glutamate ho likhoto tse tšoaroang ka koae ka ts'ebetso ea CRF2 R ke li-agonists feela tse amanang haholo le CRF-BP. Ntle le moo, keketseho ena e kopanetsoeng le CRF ea moea o kenellang hare sebakeng se ikarohantseng le boikarabello ba ho khutlisa khatello ea maikutlo boikutlong bo batlang cocaine.

Leha ho le joalo, ha ho na bopaki ba anatomical ba ho hlalosa mekhahlelo ea liketso tsa CRF sebakeng se ikhethileng.

Kahoo, re ithutile hore na CRF2 R le CRF-BP li hlahisoa litsing tsa methapo ea methapo ea methapo ea methapo, ho sebelisa tokiso ea synaptosomal e se nang likarolo tsa postynaptic.

Liphetho tsa rona li bonts'a hore liprotheine tsena ka bobeli li bonts'oa hammoho ka har'a li-synaptosomes tsa glutamatergic le GABAergic. Tlatsetso ea mantlha ea glutamatergic sebakeng sa likarolo tse kenang tsa moea tse amanang le ts'ebetso ea ho lemalla e hlahile sebakeng sa "hypothalamic" se latelang. Kahoo, re tsepamisitse maikutlo thutong ea rona ho tse ling tsa "canal" tsa "canalal" tse fumanehang sebakeng seo.

Liphetho tsa rona li bonts'a CRF2 R le CRF-BP mRNA le protheine li hlahisoa sebakeng sa "hypothalamic" le hore liproteine ​​ka bobeli li teng ka har'a li-synaptosomes tsa sebaka sa orexin.

Liphetho tsa rona tse bonts'ang CRF eo2 R le CRF-BP li hlalositsoe karolong ea morao-rao ea "hypothalamic" ea sebaka sa moea se fanang ka ts'ehetso ea maikutlo ho fana ka maikutlo a hore tlhahiso ena e bapala karolo ea khatello ea maikutlo e bakiloeng ke boits'oaro ba ho batla koae.