Lipolelo tsa Hypothalamic-pituitary-adrenal axis le sympatho-adreno-medullary nakong ea litlhoko tsa litakatso tsa cocaine tse bakoang ke khatello ea kelello le lithethefatsi (2003)

Psychopharmacology (Berl). 2003 Oct; 170 (1): 62-72. Epub 2003 Jul 4.

Sinha R1, Talih M, Malison R, Cooney N, Anderson GM, Kreek MJ.

inahaneloang

RATIONALE:

Lintho tse khothalletsang tikoloho tse amanang le koae li tsejoa li tsosa litakatso tsa lithethefatsi le ho eketsa monyetla oa ho oela hape. Leha ho le joalo, liphetoho tsa psychobiological tse etsahalang ka ho pepesetsoa hoa lisosa tsena le liketsahalong tsa litakatso tsa lithethefatsi ha li utloisisoe hantle. Phuputso ena e ile ea hlahloba karabelo ea mekhahlelo ea khatello ea kelello bokong ba tikoloho bo tsejoang ho eketsa takatso ea koae ho batho ba its'episang ka koae.

LITLHAHISO:

Phekolo ea mashome a mane a metso e mene e batlang batho ba itšetlehileng ka koae, ba ileng ba amoheloa setsing sa lipatlisiso tsa kalafo ea kalafo bakeng sa libeke tsa 2-4, ba nkile karolo lithupelong tse tharo tsa laboratori. Lintho li ile tsa pepesetsoa ts'ebetso e khutšoane ea tataiso ea 5-min e kenyelletsang ho nahana ka maemo a morao-rao a sithabetsang, boemo bo amanang le lithethefatsi le boemo ba ho se nke lehlakore, setšoantšo se le seng ka setšoantšo se fanoeng ka tatellano. Litekanyetso tse kenelletseng tsa ho lakatsa le ho tšoenyeha, litekanyetso tsa pelo le maemo a plasma a li-hormone tsa adrenocorticotrophic (ACTH), cortisol, prolactin, norepinephrine (NE) le epinephrine (EPI) li ile tsa hlahlojoa.

LIKOTSO:

Ho pepesetsoa khatello ea maikutlo le lits'oants'o tsa lithethefatsi ka bonngoe ho bakile keketseho e kholo litakatsong tsa koae le ho ts'oenyeha ho hoholo, sekhahla sa pulse, khatello ea mali ea systolic, ACTH, cortisol, prolactin le NE ha li bapisoa le karabelo litšoantšong tse sa nke lehlakore. Ntle le moo, litšoantšo tsa khatello ea maikutlo li boetse li eketsa khatello ea mali ea diastolic le EPI ea plasma ha li bapisoa le likarabo ho litšoantšiso tsa cue tsa lithethefatsi le litšoantšo tse sa jeleng paate.

CONCLUSIONS:

Liphumano li bonts'a ts'ebetso e kholo ea CRF-HPA axis le noradrenergic / sympatho-adreno-medullary (SAM) karabelo ea ts'ebetso nakong ea khatello ea maikutlo le lithethefatsi tse tlatselitseng litlamong tsa litakatso tsa koae ho batho ba itšetlehileng ka koae. Karolo ea ts'ebetso ea khatello ea maikutlo ts'ebetsong ea koae le ts'ebeliso ea koae e tšohloa.