(L) Matšoenyeho a Hormone CRF Key bakeng sa Ntšetso-pele ea Tšebeliso ea Joala (2010)

Sehlopha sa bo-ramahlale ho tsoa ho TheHTMLps Research Institute se e fumane hore hormone e ikhethileng ea khatello ea maikutlo, corticotropin-releading factor (CRF), ke senotlolo ho nts'etsopele le ho boloka ts'ebeliso ea ts'ebeliso ea joala mefuteng ea liphoofolo. Khatello ea kelello le bokhoba ba ho lemalla, ho kenyeletsa le bokhoba ba ho sheba litšoantšo tsa bootsoa.

Moprofesa Marisa Roberto, ea neng a etelletse lipatlisiso pele, o re: "Ke thabile ka thuto ena." "E bontša mohato oa bohlokoa oa ho utloisisa hore na boko bo fetoha joang ha bo tloha boemong bo tloaelehileng bo ea ho boemo bo itšetlehileng ka joala."

Boithuto bona bo bocha ha bo supe feela karolo ea mantlha ea CRF bokhobeng ba joala bo sebelisa mekhoa e fapaneng e fapaneng, empa e boetse e bonts'a hore liteketeng lihormone li ka koaloa nako e telele ho fokotsa matšoao a ts'ebeliso ea joala.

Patlisiso e fetileng e ne e amme CRF ts'ebelisong ea joala, empa e bonts'itse katleho ea ho thibela CRF feela ho litekanyetso tse le 'ngoe tse matla tsa mohanyetsi (ntho e sitisang ts'ebetso ea' mele). Boithuto ba hajoale bo sebelisitse mefuta e meraro e fapaneng ea bahanyetsi ba CRF, bao kaofela ha bona ba bonts'ang mokhoa o khahlanong le joala ka Sisteme ea CRF. Ntle le moo, tsamaiso e sa fetoheng ea mohanyetsi ea matsatsi a 23 e thibetse ho eketsa ho nooang ho amanang le ts'ebeliso ea lino tse tahang.

Tšebeliso e mpe ea tahi, e leng lefu le sa foleng le khetholloang ka tšebeliso e qobelloang ea joala le taolo ea taolo ea tahi, le utloisa batho ba malapa a bona le sechaba ka kakaretso bohloko. Hoo e ka bang karolo ea boraro ea likotsi tse bolaeang sephethephethe tsa 40,000 selemo se seng le se seng li kenyelletsa bakhanni ba tahi, 'me ho hakanyetsoa hore litšenyehelo tsa bophelo bo botle tse sa tobang le tse sa tobang ho limilione tse likete tse makholo a limilione tse likete.

"Patlisiso ea ho utloisisa bokhoba ba tahi e bohlokoa sechabeng," ho boletse Roberto, ea amohelang Moputso oa Mopresidente oa Pele oa Tlhokomelo ea Pele ho Tlhokomelo ea Bo-ramahlale le Boenjiniere. “Boithuto ba rona bo ithutile seo re se bitsang tšimong ke 'karolo e lefifi' ea bokhoba ba joala. Hona ke ho qobelloa ho nooa, eseng hobane ho monate - e bile mohopolo oa lipatlisiso tse ngata tse fetileng-empa hobane ho imolla matšoenyeho a hlahisoang ke ho se ts'oenyehe le litholoana tse sithabetsang tsa ho tlohela. ”

CRF ke ntho ea tlhaho e amehang karabong ea khatello ea mmele. Qalong e fumaneha feela sebakeng sa boko se tsejoang ka hore ke hypothalamus, joale e se e fumaneha libakeng tse ling tsa boko, ho kenyelletsa le pituitary, moo e tsosang sephiri sa corticotropin le lintho tse ling tse sebetsang ka biologi, le amygdala, sebaka se kileng sa ba teng e kenelletse matšoenyehong a phahameng, ho tlohela, le ho nwa ho feteletseng ho amanang le ts'ebeliso ea lino tse tahang.

Ho netefatsa karolo ea CRF karolong e bohareng ea amygdala bakeng sa ts'ebeliso ea joala, sehlopha sa lipatlisiso se sebelisitse mokhoa o fapaneng oa kenyelletso o kenyelletsang mekhoa ea electrophysiological e neng e sa sebetse bothateng bona.

Liphetho tse tsoang lipatlisisong tsena tsa cellular li bonts'itse hore CRF e matlafalitse matla a inhibitory synapses (junctions pakeng tsa lisele tse peli tsa methapo) ho li-neurons ka tsela e ts'oanang le joala. Phetoho ena e etsahetse ka tokollo e eketsehang ea neurotransmitter GABA, e phethang karolo ea bohlokoa ho taolo ea thabo ea neuronal.

Ka mor'a moo, sehlopha se ile sa hlahloba hore na litlamorao tsa CRF li ka thibeloa ka tsamaiso ea bahanyetsi ba CRF. Ho etsa sena, bo-ramahlale ba lekile bahanyetsi ba bararo ba CRF1 (e bitsoang antalarmin, NIH-3, le R121919) Khahlano le joala bo bang malikeng a bokong 'me ba kentse R121919 bakeng sa matsatsi a 23 matsatsing a likotsi a neng a pepesehetse maemo ao ka tloaelo a neng a tla hlahisa tlhahiso joala.

Ho makatsang ke hore, boits'oaro ba litoeba tsa "ho itšetleha ka joala" bo amohelang e mong oa bahanyetsi ba CRF (R121919) bo ile ba etsisa bo-mphato ba bona bao eseng "lekhoba". Sebakeng sa ho batlana le joala bo bongata joalo ka likhoto tse sa tsoaloang tse tahang joala, litonki ka bobeli le bakuli ba bona ba sa noeng joala joala haholo.

Roberto o itse: "Phatlalatso ena e bohloko e bonts'a hore ts'ebetso e eketsehileng ea ts'ebetso ea CRF e thusa ho nwa haholo ho amanang le nts'etsopele ea boiketlo." "Ka mantsoe a mang, ho thibela CRF ka taolo ea nako e telele ea CRF1 ho ka thibela tšebeliso e mpe ea joala ho tlasa maemo a fapaneng a boitsoaro le 'mele."

Habohlokoa, thutong eo litoeba li ne li sa bonts'e mamello ho litlamorao tsa R121919 mabapi le joala. Ebile, ba kanna ba ba le ho ameha haholo ka litlamorao tsa eona ha nako e ntse e tsamaea — pontso e ntle ea ho sebetsa ha mofuta ona hantle kaha e ka sebelisoa khafetsa maemong a kliniki.

Lithuto tsa bo-ramahlale tsa bo-rasaense li boetse li tšehelitse litlamorao tse tšepisang tsa bahanyetsi ba CRF1. Bohle bahanyetsi ba CRF ba fokotsetse likarabo tsa basal GABAergic le ho felisa litlamorao tsa joala. Likhoto tse itšetlehileng ka joala li bontšitse maikutlo a matla ho CRF le bahanyetsi ba CRF1 ka tokollo ea GABA sebakeng se bohareng ba amygdala bokong. Ts'ebetso ea mohanyetsi oa CRF1 ho amygdala e bohareng e khutlisitse likhakanyo tse amanang le ts'epahalo ho GABA ea kantle ho naha le ho sitisa keketseho e bakoang ke joala ho extracellular GABA ka bobeli le litheko tse sa tsebeng letho. Maemo a CRF le CRF1 mRNA ka har'a amygdala e bohareng ea likhoto tse itšetlehileng le tsona li ile tsa phahamisoa.

Roberto o hlokomela hore karolo e 'ngoe e khahlang ea mosebetsi ke hore e fana ka khokahano ea' mele pakeng tsa boits'oaro bo amanang le khatello ea maikutlo, mathata a maikutlo (ke hore khatello ea maikutlo, ho tšoenyeha, khatello ea maikutlo), le nts'etsopele ea ts'ebeliso ea lino tse tahang.

Ho khanna Tlas'a Tšusumetso, Ho Tsamaisa Ha U Ntse U Ngotsoe, le Ho sebetsa Tlas'a Tšusumetso ho ka fella ka tahlehelo ea lengolo la hau la ho khanna. Sireletsa laesense ea driver ea hau le botumo ba hau ka ho ikopanya le 'Muelli oa molao oa San Diego DUI

References:

1. Marisa Roberto, et al. Ho lokolloa ha Corticotropin Factor-E thehiloe Amygdala Gamma-Aminobutyric Acid ho etsa Karolo ea Bohlokoa Boemong ba Tahi. Psychology Psychiki, doi: 10.1016 / j.biopsych.2009.11.007

LINK