Ho lahleheloa ha nako e telele ea dopamine ho lokolloa ho fanoa ke li-receptor tsa CRF-1 ka mor'a likhoeli tse tharo tse latellanang ka mor'a k'hok'heine. (2013)

Behav Brain Res. 2013 May 16. pii: S0166-4328 (13) 00283-0. Doi: 10.1016 / j.bbr.2013.05.012. [Epub pele ho khatiso]

Sotomayor-Zárate R, Renard GM, Araya KA, Carreño P, Fuentealba JA, Andrés ME, Gysling K.

mohloli o moholo

Nyutlelie ea Mahlale a Millenium ho khatello ea maikutlo le lemalla ntho e, Lefapha la Lisele le Biology ea Limolek'hule, Lefapha la Saense ea Bioloji, Pontificia Universidad Católica de Chile; Centro de Neurobiología y Plasticidad Cerebral, Departamento de Fisiología, Facultad de Ciencias, Universidad de Valparaíso.

inahaneloang

Hamorao ke "septum" ke boko bo amanang le khatello ea maikutlo le lithethefatsi lemalla ntho. Mona re bontša hore maemo a dopamine extracellular maemong a morao septum a tlas'a taolo ea corticotrophin releasing factor (CRF). Reverse dialysis ea 1μM stressin-1, agonist ea mofuta oa 1 CRF receptor (CRF-R1), e bakile keketseho e kholo ea litekanyetso tsa LS dopamine extracellular maemong a phekolo ea saline a neng a thibetsoe ke kopanyo ea khatello ea khatello ea khatello ea maikutlo (X -UMNXX) le CP-1 , mohanyetsi ea khethehileng oa CRF-R154526. Tsamaiso e pheta-phetoang ea koae (1mg / kg; habeli ka letsatsi bakeng sa matsatsi a 15) e hatelletse ho eketseha ha litekanyetso tsa LS dopamine extracellular tse hlahisoang ke ts'ebetso ea CRF-R14. Khatello ena e ile ea bonoa 1hours, hammoho le matsatsi a 24 kamora ho khaotsa ho tsoa taolong ea koae e phetoang khafetsa.

Ntle le moo, ho lokolloa ha depoparization-induced dopamine ho LS e ne e phahame haholo ho cocaine- ha e bapisoa le likhoto tse tšoaroang ka letsoai. Kahoo, Liphetho tsa rona li bonts'a hore ts'ebetso ea CRF-R1 ho LS e etsa hore ho be le keketseho e kholo maemong a dopamine extracellular. Ho khahlisang, taolo ea koae e pheta-phetoang e etsa hore khatello ea nako e telele ea CRF-R1 e kopane le phepelo ea nako le nako le keketseho ea nako le nako ea dopamine e be teng ho LS.