Ho tlohela methamphetamine ho etsa hore ho be le liphetoho ho μ-opioid receptor, oxytocin le CRF systems: Mokhatlo o nang le phenotype ea anxiogenic (2016)

Neuropharmacology. 2016 Feb 16. pii: S0028-3908(16)30047-8. doi: 10.1016/j.neuropharm.2016.02.012.

Georgiou P1, Zanos P1, Garcia-Carmona JA2, Hourani S1, Kichine ea I1, Laorden ML2, Bailey A3.

inahaneloang

Phephetso e kholo ho phekoleng bokhoba ba methamphetamine ke ho boloka boemo ba lithethefatsi bo le sieo hobane ba na le matšoao a fosahetseng a maikutlo nakong ea ho se sebetse, e leng se ka bakang ho khutla hape. Mekhoa ea neuronal e etsang hore motho a khaotse ho khutla le ho khutla hape ha e e-so utloisisoe hantle. Ho na le bopaki bo supang karolo ea oxytocin (OTR), μ-opioid receptor (MOPr), dopamine D2 amohela (D2R), lits'ebetso tsa corticotropin-releasing factor (CRF) le hypothalamic-pituitary-adrenal (HPA) -axis ka mekhahlelo e fapaneng ea bokhoba ba methamphetamine. Thutong ena, re ikemiselitse ho supa litla-morao tsa boitšoaro ba ho tlosoa ha methamphetamine litoeba le ho lekola modumo oa OTR, MOPr, D2R, CRF le HPA-axis e latelang ts'ebetso ea methamphetamine e sa foleng le ho khaotsa. Tsamaiso ea methamphetamine ea matsatsi a leshome (2 mg / kg) e ile ea eketsa tlamo ea OTR ho amygdala, ha matsatsi a 7 a ho tlosa a ne a kenya ts'ebetsong ea receptor ena ho septum ea morao. Phekolo ea methamphetamine e sa foleng e ile ea eketsa maemo a OT ea plasma a ileng a khutlela maemong a taolo kamora ho tlohela. Ntle le moo, taolo ea methamphetamine le ho tlosa ho tlosoa ha MOPr ho eketsehile, hammoho le c-Fos+/ CRF+ polelo ea neuronal ho amygdala, athe keketseho ea lipalo tsa corticosterone ea plasma e ile ea bonoa kamora taolo ea METSI, empa eseng ho khaotsa. Ha ho na phapang e ileng ea bonoa ho D2Ho tlama ho latela taolo ea METH le ho tlosa. Liphetoho tse tsamaisong ea OTR, MOPr le CRF li etsahetse ka mokhoa o fapaneng le matšoao a amanang le ho tšoenyeha le nts'etsopele ea maikutlo a kelello nakong ea ho ikhula. Ka kopanelo, liphumano tsa rona li bonts'a hore tšebeliso ea methamphetamine e sa foleng le ho itlosa bolutu li ka baka li-nuroadaptations tse ikhethileng tsa ts'ebetso ea OTR, MOPr le CRF, tseo ka bonyane li ka hlalosang litlamorao tse amanang le ho tlosoa.

LINKOTSO: Matšoenyeho; CRF; Ho tlosoa ha Methamphetamine; Oxetocin; Receptor ea μ-opioid