Mekhoa ea methapo ea potoloho ea li-neural: e leng corticotropin e lokollang hormone (CRH) e bontšang dopaminergic neurons ea ventral tegmental (VTA) e ka thibela matšoenyeho (2018)

Mekhoa ea ho potoloha ea maikutlo e bonts'itsoeng

June 12, 2018, Mokhatlo oa Max Planck

CRH neurons (e khubelu) ho amygdala. Mokitlane: MPI ea Psychiatry

Ho latela tlaleho ea Mokhatlo oa Lefatše oa Bophelo, haufi le 1 ho batho ba 10 lefatšeng ba angoa ke matšoenyeho le / kapa khatello ea maikutlo. Ka mokhoa o makatsang, palo eo e batla e imenne habeli, ho tloha ho 416 milione ho isa ho 615 milione, lipakeng tsa 1990 le 2013. Kaha kalafo e lekaneng e ntse e haella bakeng sa bakuli ba bangata, bo-rasaense ba Max Planck Institute of Psychiatry ba tšepa hore lipatlisiso tsa bona li tla tsebisa nts'etsopele ea mekhoa e mecha e sebetsang ea kalafo.

Phuputsong e fetileng, e phatlalalitsoeng ho Science ka 2011, sehlopha sa Jan Deussing se senotse ka lekhetlo la pele hore corticotropin e lokollang li-hormone (CRH) e tšoaea dopaminergic neurons ea sebaka sa ventral tegmental (VTA) se ka fokotsa khatello ea kelello.

Thutong ea bona ea morao-rao, sehlopha sa Deussing se atolositse liphuputsong tsena, se fana ka leseli le fetang la mechini ho potoloho ea "anxiolytic" CRH. E phatlalalitsoe koranteng e tummeng Nature Neuroscience, bo-ramahlale ba hlalosa kamoo potoloho e simolohang ho amygdala e atolositsoeng, ho palo ea li-neuron tsa GABAergic tse hlahisang CRH. Ba batlile methapo ena ea kutlo 'me ba bona hore ba kenella sebakeng sa thoteng e bitsoang VTA, e leng e' ngoe ea likarolo tsa mantlha tse hlahisang boko. VTA e tsejoa e bapala karolo ea bohlokoa moputsong le bokhobeng, empa mona bangoli ba hlalosa kamoo CRH le dopamine li kenang boits'oarong bo amanang le ho tšoenyeha.

Li-neurons tse nang le CRH tse nang le li-neuron tsa li-amygdala tse holisitsoeng tsa li-receptor tsa CRH ho li-dopaminergic VTA neurons. Ka lebaka leo, potoloho ena e ka laola phetisetso ea dopaminergic ka lehlakoreng le leng, ea ama maikutlo.

Li-neurons tsa CRH sebakeng sa projeke ea amygdala (CeA, botala) ho ea sebakeng sa ventral tegmental (VTA). Dopaminergic neurons (e khubelu) le li-terminals tsa axon tse kopaneng tsa li-neurons tsa CRH (botala). Mokitlane: MPI ea Psychiatry

Sengoli se etelletseng pele sa thuto ea hajoale Nina Dedic o hlalosa bohlokoa ba liphuputso: “Rea tseba hore CRH ke eona e khannang haholo karabelo ea khatello ea maikutlo le hore sistimi ea CRH e sa sebetseng e amehile ho mafu a methapo ea pelo joalo ka mathata a maikutlo le matšoenyeho. Leha ho le joalo, thutong ena, re ka bonts'a hore CRH ha se kamehla e sebetsang joalo ka moriana o thibelang khatello ea maikutlo o fokotsang khatello ea maikutlo. Ebile, lisekete tse khethehileng tsa CRH li hlokahala ho boloka boemo bo botle bo le maemong a tloaelehileng a se nang khatello ea maikutlo. ”

Deussing, moetapele oa sehlopha sa lipatlisiso le hlooho ea thuto, oa hlalosa: “Re ile ra makala ha re fumana hore karoloana ea li-neurone tsa GABAergic CRH ka har'a amygdala e atolositsoeng e na le mokokotlo oa dendritic mme e hlahisa protheine ea postynaptic density, Camk2a. Litšobotsi tsena li bonahala hangata methapong ea methapo ea kutlo. ” O tsoela pele: "Mosebetsi oa rona o fana ka maikutlo a hore li-neuron tsa CRH ho amygdala e atolositsoeng li fapane ho feta kamoo re neng re nahana ka pele. Ho na le li-interneuron tsa lehae tse hlahisang li-spiny, GABAergic, li-neuron tsa nako e telele. ”

Ntle le ho senola kamoo CRH e sebelisanang le dopamine ho laola matšoenyeho, sehlopha sa Deussing se ts'epa hore liphuputso tsena li tla thusa ho rarolla lipotoloho tse rarahaneng tsa khatello ea maikutlo le marang-rang a boko.

https://b98584f181.site.internapcdn.net/tmpl/v5/img/1x1.gifHlahloba ho eketsehileng: Bo-rasaense ba bontša kamoo potoloho ea boko e hlahisang matšoenyeho

Boitsebiso bo eketsehileng: Nina Dedic et al. Ho fokotseha ha CRH ho sa feleng ho tsoa ho GABAergic, li-neurons tsa bolelele ba nako e telele ho amygdala e atolosang ho fokotsa ho lokolloa ha dopamine mme ho eketsa ho tšoenyeha, Nature Neuroscience (2018). MOTSO: 10.1038 / s41593-018-0151-z