Nat Commun. 2013;4:1579. doi: 10.1038/ncomms2598.
Sim HR1, Choi TY, Lee HJ, Kang EY, Yoon S, Monghali PL, Choi SY, Baik JH.
inahaneloang
Lisebelisoa tsa dopaminergic li na le tšusumetso ho boits'oaro bo amanang le khatello ea maikutlo. Mona re fuputsa likarabo tsa boits'oaro ho khatello ea maikutlo ho litoeba tsa dopamine D2 receptor knockout mme re fumana hore boits'oaro bo joalo ba ho tšoenyeha bo eketseha ha bo bapisoa le litoeba tsa mofuta o hlaha. Ho pepesetsoa khafetsa ha khatello ea maikutlo ho hatella maikutlo a khothalletsoang a koae, ho batla koae le ho khutlisa boits'oaro ho dopamine D2 receptor knockout mice. Phephetso ea Cocaine kamora ho tlosoa hoa lithethefatsi ho mofuta oa cocaine o nang le boiphihlelo ba dopamine kapa dopamine D2 receptor knockout e amana le thibelo ea khatello ea maikutlo ea nako e telele ho li-nucleus tsa li-nucleus, le khatello ea maikutlo nakong ea ho khaotsa ho thibela ts'ebetso ka mor'a phephetso ea koae ho "cocaine-dopamine D2" ea receptor. litoeba, empa eseng litoeba tsa mofuta oa hlaha Ho putlama ha moea oa "dopamine D2" ho "nucleus" e kenang ka mpeng ha ho ame tšebetso ea basal locomotor, empa ho fana ka maikutlo a sitisang khatello ea maikutlo ea ts'ebetso ea koae. Linta tse sithabetseng tse felisitsoeng ke dopamine D2 receptors ha li bontše tšitiso ea nako e telele ea khatello ea maikutlo. Liphetho tsa rona li fana ka maikutlo a hore li-receptor tsa dopamine D2 li na le karolo ea ho laola phetoho ea synaptic e bakoang ke khatello ea maikutlo le bokhoba ba lithethefatsi.
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