Ho hōlisa boiketlo ba sechaba ho eketsa nucleus accumbens dopamine le norepinephrine likarabo ho ethanol e matla ha motho e moholo (2014)

Alcohol Clinic Exp Res. 2014 Nov;38(11):2770-9. doi: 10.1111/acer.12555.

Karkhanis AN1, Locke JL, McCool BA, Weiner JL, Jones SR.

inahaneloang

LITLHAHISO:

Matšoenyeho a bophelo ba bongoaneng a amana le ho ba kotsing ea ho lemalla joala. Leha ho le joalo, likarolo tse nyane tsa neural tse amanang le khatello ea maikutlo ea bongoana / ea bongoaneng le kotsi e eketsehang ea ho lemalla joala ha li utloisisoe hantle. Ho li-nucleus accumbens (NAc), dopamine (DA) le lipontšo tsa norepinephrine (NE) li ka susumetsoa haholo ke khatello ea maikutlo, matšoenyeho le lithethefatsi tsa tlhekefetso, ho kenyelletsa ethanol (EtOH). Mona, re sebelisitse mohlala oa phepelo ea khatello ea maikutlo bophelong ba bongoaneng e lebisang ho eketseheng ha maemo a kotsi a bokhoba ba tahi ho fumana kutloisiso e hlakileng ea hore na khatello ea maikutlo ea bongoana e sa feleng e ka ama joang maikutlo a EtOH a DA le ho lokolloa ha NE ho NAc.

LITLHAHISO:

Likhoto tsa banna ba Long-Evans li ne li lula ka har'a sehlopha (GH; likhoto / cage tse 4) kapa li arotsoe sechabeng (SI; 1 rat / cage) bakeng sa libeke tse 6 ho qala ka letsatsi la pelehi la 28. Likhoto tsa SI le GH li ile tsa lekoa nakong ea botsofali bakeng sa boits'oaro bo ts'oanang le ba matšoenyeho. (maze e phahameng haholo), le litlamorao tsa EtOH (1 le 2 g / kg; intraperitoneally.) ho NAc DA le NE li ile tsa hlahlojoa ka microdialysis.

LIKOTSO:

Liphoofolo tsa SI li bontšitse boitšoaro bo eketsehileng ba ho tšoenyeha ha bo bapisoa le liphoofolo tsa GH. Le ha SI e ne e sena phello maemong a mantlha a DA kapa NE, maemo a mantlha a DA a ne a hokahane hantle le mehato ea matšoenyeho. Ntle le moo, leha ho ne ho se liphapang tse kholo tse bonoeng ka 1 g / kg EtOH, lethal dose la 2 g / kg le hlohlellelitse tokollo e kholo ea DA liphoofolong tsa SI. Ho feta moo, EtOH (2 g / kg) e phahamisitse feela maemo a NAc NE ho likhoto tsa SI.

CONCLUSIONS:

Liphetho tsena li fana ka maikutlo a hore khatello ea maikutlo ea bongoaneng ea bongoana e ts'oenya kelello ea DAUM le ho lokolloa ha NE ka lebaka la phephetso e matla ea EtOH. Boikutlo bo boholo ba EtOH ba DA le li-NE tse matlafatsoang ho NAc li ka kenya letsoho keketseho ea maemo a mabe a boits'oaro ba joala, joalo ka boits'oaro bo boholo ba EtOH, bo shejoang ho litoeba tsa SI.

Copyright © 2014 ke Mokhatlo oa Bafuputsi mabapi le Joala.

LINKOTSO:

Dopamine; Ethanol; Norepinephrine; Li-Accumbens tsa Nyutlelie; Ho Itšehla thajana