Matšoenyeho a flips cocaine a khutlela ho 'on'; lipatlisiso li e khutlisetsa ho 'off' (2017)

Mmesa 11, 2017 ke David Orenstein

Ntho e utloisang bohloko ke ho lemalla feela hore ketsahalo e khutšoane e sithabetsang e ka re ho tsosa hape. Phuputsong e ncha e qaqileng ea ho lemalla koae e entsoeng ka har'a litekanyetso tsa rat, e lumellanang hantle le ts'ebetso ea bokhoba ba batho, bo-rasaense ba tsebahetse se etsahalang ka har'a kelello ea mammone ho etsa joalo mme ba sibolla biolo ea limolek'hule e ba lumellang hore ba fetole khatello e bakiloeng ke khatello ea maikutlo khutlela morao.

Se fumanoeng, se phatlalalitsoe koranteng Life, fana ka tlhahiso ea mokhoa o mocha oa ho qapa meriana e loantšang , esita le letsatsi kapa ho feta ka mor'a hore khatello ea maikutlo e etsahale.

"Seo se bohlokoa haholo hobane ha o batle ho noa meriana nako eohle o lebelletse khatello ea maikutlo," ho boletse mongoli ea phahameng Julie Kauer, moprofesa oa molek'hule ea limolek'hule, fisiks le biotechnology Univesithing ea Brown.

Tsela ea ho oela hape e ntse e phehella

Bohareng ba thuto ke li-kappa opioid receptors (κORs) tse kaholimo ho lisele tsa bohlokoa tsa boko. Li-κOR li se ntse li bonoa e le sepheo sa nts'etsopele ea meriana e khahlano le ho lemalla lithethefatsi, empa ho etsa litlhare tse sebetsang, bafuputsi ba tlameha ho supa litšebelisano tse itseng. Thutong e ncha, sehlopha sa bo-rasaense ba Kauer sa Brown le Univesithi ea Wyoming se hlokometse ka ho itshwara ka likhoto le ka lisele tsa boko ba likhoto ho shebisisa hore na khatello ea maikutlo e bonahala e baka li-receptor joang hore li bake ho oela hape, hore na ho khutlela morao ho lula ho tsitsitse joang le hore na phello eo e joang e ka sitisoa.

Boithuto bo shebile sebakeng sa "ventral tegmental tegmental" (VTA), moo boko bo matlafatsang boits'oaro bo amanang le ho fihlela litlhoko tsa mantlha. Ka linako tse ling tseo e ba litlhoko tse phetseng hantle, joalo ka lijo, empa hape e ka ba litakatso tsa lithethefatsi, joala kapa nikotine. Ka har'a VTA, moputso oa litlhoko tse khotsofatsang o kenella ka li-neurons tse tsoang ka ntle ho neuropransmitter dopamine. Li-neuron tsena lia khaotsa, leha ho le joalo, ke inhibitory neurotransmitter GABA, ka khokahano ea li-neurons tse ling tse bitsoang li-synapses.

Litsebi tsa litsebi tsa kelello li tseba hore, joalo ka batho, khatello ea maikutlo e etsa hore motho a boele a ts'oare litheko. Mochine o mong ke ho ntšoa ha protheine e bitsoang dynorphin eo ka tlhaho e sebetsang ka li-κOR. Boithuto bona bo bocha bo fana ka bopaki ba hore kamora khatello e matla ea nakoana, dynorphin e baka phetoho ea nako e telele ho kopanngoeng ha li-receptors, ka ho khetheha ho li-synapses tsa GABA-tse lokollang tse thibelang li-neurop tsa ho lokolla dopamine ho VTA.

Phetoho ena e khethehileng e hlahisoa ke ho senya bokhoni ba GABA ba ho thibela ts'ebetso ea dopamine neuron e ka tsamaeang -Seking. Hang ha phetoho ea tumellano e entsoe ka har'a li-κOR, bafuputsi ba fumane, phetoho e khothalletsang phetoho e lula e sebetsa matsatsi a mangata ntle le khatello e eketsehileng kapa tlhoko e tsoelang pele ea dynorphin.

Hore li-OROR li ntse li tsoela pele ho itšoara ka tsela e ts'oanang matsatsi a mangata le kamora hore tšusumetso e le 'ngoe feela e khuts'oane e fumanoe bocha ho neuroscience, bangoli ba ngotse ho eLife: "Ea rona ke pontšo ea pele ea liphetoho tse bakiloeng ke boiphihlelo ts'ebetsong ea li-receptor tsena."

Ho khutlisa hape

Ka pampiri e fetileng, bafuputsi ba bonts'itse hore naek'hemistra e ka felisang phepelo eo hape. Ka pampiri e ncha, ba bonts'itse hore ba ka khutla hape le NorBNI litekong esita le letsatsi le felletseng ka mor'a khatello.

Joale ba boetse ba tseba haholoanyane ka hore na seo se sebetsa joang. Tekong ea mantlha thutong e ncha, ba bonts'itse hore NorBNI e kenya tšebetsong tsela ea limolek'hule tse li-neuron tse bitsoang JNK (e bitsoa "junk") ho khutlisetsa li-kOR ho sebopeho sa tsona se tloaelehileng se sa bonts'eng ho saena ka nako e telele. Ba boetse ba bonts'a hore ho thibela feela dynorphin ho tlama ho li-κOR ha hoa khutlisetsa ts'ebetso ea GABAergic neuron mme ka hona e ke ke ea ba leano le atlehang la nts'etsopele ea lithethefatsi.

Tekong e 'ngoe, ba bontšitse hore ha ho khutlela morao ho ka thibeloa ka ho thibela ho lokolloa ha dynorphin pele khatello ea maikutlo e etsahala, ho thibela ho lokolloa ha dynorphin kamora khatello ea maikutlo ha ho na thuso. Mosebetsi o malimabe oa Dynorphin o se o entsoe.

Ha ho fanoa ka bopaki ba bona, seo sehlopha sa Kauer se nahanang ke hore khatello ea maikutlo, ka dynorphin, e hlakola konopo ho li-κOR tse tima letšoao le tloaelehileng la GABA ho li-synapses tse loketseng matsatsi. Ho sebelisa norBNI ho tšoana le ho phethola sesebelisoa se seng, ka JNK, se pholosang lets'oao le tloaelehileng la GABA.

Ho pharmacology ea batho, Kauer o amohetse, norBNI ha e amoheloe hobane litlamorao li teng libeke mme li ka baka litlamorao tse sa batleheng, empa ke ka hona ho leng molemo ho tseba hore e sebelisa tsela ea JNK ho etsa mosebetsi oa eona.

"JNK e tla ba mokhoa oa bohlokoa oa nakong e tlang oa ho theoha," ho boletse Kauer. "Mohlomong u ka sebelisa ntho e 'ngoe ntle le norBNI ho khanna JNK."

Seo, ka nako e 'ngoe se neng se ka fa batho ba hlaphohileng bokhobeng ba koae ka moriana o thibelang ho khutla ha litakatso ka lebaka la .

Bala ho eketsehileng ka: https://medicalxpress.com/news/2017-04-stress-flips-cocaine-relapse.html#jCp