Ho imeloa kelellong nakong ea bocha le lithethefatsi tsa tlhekefetso ka mekhoa ea litoeba: karolo ea dopamine, CRF le HPA axis (2014)

Psychopharmacology (Berl). 2014 Apr;231(8):1557-80. doi: 10.1007/s00213-013-3369-1.

Burke AR1, Miczek KA.

inahaneloang

RATIONALE:

Patlisiso mabapi le bohlankana le tlhekefetso ea lithethefatsi e eketsehile haholo lilemong tse leshome tse fetileng. Leha ho le joalo, litloaelo tse amanang le bokhoba ba lithethefatsi tse latelang liphihlelo tse sithabetsang nakong ea bocha ha li ithutoe hanyane. Re shebana le mehlala e atileng ea khatello ea maikutlo ea bongoaneng ho lithethefatsi tsa tlhekefetso.

LIPOTSO:

Lekola botjha ba boitšoaro, dopamine, corticotropin-releasing factor (CRF), le hypothalamic-pituitary-adrenal (HPA) axis lithutong tsa bocha. Re lekola bopaki ba hore liphihlelo tse sithabetsang nakong ea bohlankana li etsa hore lithethefatsi tsa tlhekefetso li be matla le ho fana ka mekhoa e ka bang teng ea neural.

LIPOTSO LE LIPOTSO

Bopaki bo bongata bo fana ka maikutlo a hore phetoho ea ho qetela ea boits'oaro, lits'ebetso tsa dopamine le axis ea HPA e etsahala nakong ea bohlankana. Khatello ea maikutlo nakong ea bocha e eketsa ho khothaletsoa ha amphetamine- le ethanol, ho rata le ho itaola tlas'a maemo a mangata. Tšusumetso ea khatello ea lilemong tsa bocha ho koaheng le ho ts'oaroang ha nicotine ka morao ho moo ha e hlake. Mofuta oa khatello ea bocha, nako ea nakoana lipakeng tsa khatello ea maikutlo le tlhahlobo, mefuta, thobalano le tlhahlobo ea lithethefatsi ke tsona litlhare tsa bohlokoa tsa ts'ebetso ea katleho ea maikutlo. Ho khothaletsoa matla a mesolimbic dopamine system ho fana ka maikutlo a matla a tlisoang ke lithethefatsi tsa tlhekefetso ho bacha le ho batho ba baholo ka ho feto-fetoha ha maikutlo ke CRF. Mefuta e fokotsehileng ea dopamine ea mesocortical e bonahala e le phello e ikhethang ea khatello ea maikutlo nakong ea bohlankana. Matšoenyeho a bongoaneng a ka fokotsa ho fetoha ha dopamine ea cortical ka D2 dopamine receptor regulation of dopamine synthesis kapa glucocorticoid e nolofalitsoeng ea ho faola limela tsa cortical dopamine. Mefuta e meng ea bohloeki ba bocha e bohlokoa bakeng sa ho khetholla mekhoa ea methapo e tsamaisang maikutlo a tlisoang ke litlhare tsa tlhekefetso.