Batho ba hlekefetsang bakuli ba cocaine ba batlang ho phekola kalafo ba bontša ho nyenyefatsa ha molumo oa bobeli ba prolactine le chereisol (2003)

Neuroendocrinology. 2003 Sep;78(3):154-62.

Contoreggi C1, Herning RI, Koeppl B, Simpson PM, Negro PJ Jr, Fortton-Burton C, Hess J.

inahaneloang

Cocaine e baka khaello ea neuroendocrine ho batho ba hlekefetsang koae ka secretion ea "pituitary" e fanang ka fensetere tsamaisong ea khatello ea kelello bokong. Ba hlekefetsang lithethefatsi le barupeluoa ba taolo ba ile ba hlahisoa ka bohanyetsi bakeng sa libeke tsa 3. Ba hlekefetsang ba bonts'itse litheko tse phahameng tsa basal ka har'a prolactin ka beke ea 1 ka ho tloaela ho feta libekeng tsa 3. Ha ho na phapang ea secretion ea prolactin e ileng ea bonoa ka tšusumetso ea hormone ea thyrotropin kapa tokollo ea khatello ea L-dopa. Secretion ea Basal thapama ea cortisol e ile ea phahamisoa haholo nakong ea libeke tsa 1 le 2 ha li bapisa ba hlekefetsang le taolo. Secretion e phahameng ea mantsiboea cortisol ke sesupo se tebileng sa ts'ebetso ea khatello ea maikutlo. Liphetho tsena li supa ho hypothalamus, eseng sebakanyana sa pituitary, kaha e fetoloa haholo ho tlosoeng ha koae. Lintlha li bonts'a hore li-axop tsa dopamine-prolactin le hypothalamic-pituitary-adrenal (HPA) lia ameha nakong ea ho khaotsa koae. Ha meriana e ntse e ntlafatsoa ho fetola ts'ebetso ea khatello ea maikutlo e sa sebetseng hantle, lithuto tsa kalafo tsa bokamoso tsa tšebeliso e mpe ea lithethefatsi, ho tlohela, ho lakatsa le ho khutla li tlameha ho sebelisa liteko tsa morao-rao tsa ts'ebetso ea hypothalamic pituitary, haholo-holo axis ea HPA, kaha tlhahisoleseling ena e ka ba tataiso ho ts'ebetsong ea lefu lena. le ho bolela likarabo tsa kalafo.