Journal of Narkoba sarta Alkohol Panalungtikan
vol. 2 (2013), Pasal ID 235651, kaca 11
Full-téks PDF
Doi: 10.4303 / jdar / 235651
Eric J. Nestler
Fishberg Departemen neurosains na Friedman Brain Institute, Gunung Sinai Sakola Kadokteran, Hiji Gustave L. Levy Tempat, Box 1065, New York, NY 10029, AS
Nampi 2 Nopémber 2012; Dirévisi 10 Nopémber 2012; Ditarima 20 Nopémber 2012
abstrak
ΔFosB mangrupakeun anggota kulawarga Fos faktor transkripsi. Bari sakabeh anggota kulawarga séjén anu ngainduksi gancang tapi transiently di respon ka host of rangsangan akut, ΔFosB nyaéta unik dina eta eta accumulates di respon kana rangsangan ngulang alatan stabilitas protéin ilahar na.
Induksi prolongFosB anu berkepanjangan, dina daérah pahala otak, parantos kairut dina modél sato kecanduan narkoba, kalayan seueur bukti nunjukkeun yén ΔFosB ngamajukeun pahala sareng motivasi sareng janten mékanisme konci sensitipitas narkoba sareng ningkatkeun administrasi diri narkoba . Ieu parantos divalidasi dina postmortem manusa, kalayan tingkat ΔFosB luhur ditingali di daérah pahala otak anu kecanduan.
Salaku faktor transkripsi, ΔFosB ngahasilkeun phenotype behavioral ku ngatur éksprési gén target husus. Kami identifying target transcriptional misalna tina ΔFosB ku cara maké pendekatan gén calon ogé ku cara maké padika génom-lega. Karya panganyarna geus dianalisis chromatin remodeling-parobahan dina modifikasi posttranslational of histones jeung protéin nuklir lianna di ubar-diatur gén-mun delineate mékanisme molekular lengkep ku nu ΔFosB ngatur éksprési gén target di vivo ka nyapih ubar-ngainduksi synaptic, neural, sarta behavioral plasticity. studi ieu tina ΔFosB nu nyadiakeun wawasan anyar kana dasar molekul tina kecanduan obat nu keur watesan hiji host tina target anyar pikeun mungkin ngembangkeun terapi.
Rujukan
- IN Alibhai, TA Héjo, JA Potashkin, sarta EJ Nestler, Pangaturan fosB na fosB mRNA éksprési:? Di vivo na di studi vitro, Brain res, 1143 (2007), 22-33.
- E. Ang, J. Chen, P. Zagouras, H. Magna, J. Holland, E. Schaeffer, et al., Induksi ti nuklir faktor-B dina intina accumbens ku administrasi kokain kronis, J Neurochem, 79 (2001), 221-224.
- M. Asanuma na JL Cadet, kanaékan Methamphetamine-ngainduksi di NF-B DNA-mengikat aktivitas striatal ieu attenuated di superoksida mencit transgenik dismutase, Mol Brain res, 60 (1998), 305-309.
- O. Berton, anjeunna Covington 3rd, K. Ebner, nm Tsankova, TL Carle, P. Ulery, et al., Induksi ti? FosB di abu periaqueductal ku stress promotes réspon coping aktip, Neuron, 55 (2007), 289-300.
- JA Bibb, J. Chen, JR Mekarwangi, P. Svenningsson, A. Nishi, GL Snyder, et al., Épék tina paparan kronis jeung kokain nu diatur ku protéin neuronal Cdk5, Alam, 410 (2001), 376-380.
- A. Manuk, Persepsi tina epigenetics, Alam, 447 (2007), 396-398.
- TL Carle, yn Ohnishi, YH Ohnishi, IN Alibhai, MB Wilkinson, A. Kumar, et al., Proteasome-gumantung jeung -independent mékanisme pikeun FosB destabilization: idéntifikasi of FosB domain degron jeung implikasi pikeun stabilitas FosB?, Eur J Neurosci, 25 (2007), 3009-3019.
- J. Chen, MB Kelz, BT Hope, Y. Nakabeppu, sarta EJ Nestler, Kronis antigén Fos-patali: varian stabil tina FosB ngainduksi dina otak ku perlakuan kronis?, J Neurosci, 17 (1997), 4933-4941.
- J. Chen, MB Kelz, G. Zeng, N. Sakai, C. Steffen, pe Shockett, et al., sato transgenik kalawan inducible, ekspresi gen sasaran dina uteuk, Mol Pharmacol, 54 (1998), 495-503.
- J. Chen, SS Newton, L. Zeng, DH Adams, AL Dow, TM Madsen, et al., Downregulation tina béta protéin CCAAT-enhancer ngariung di mencit transgenik? FosB na ku seizures electroconvulsive, Neuropsychopharmacology, 29 (2004), 23-31.
- J. Chen, anjeunna Nye, MB Kelz, N. Hiroi, Y. Nakabeppu, BT Hope, et al., Pangaturan? FosB na FosB-kawas protéin ku rebutan jeung kokain perlakuan electroconvulsive, Mol Pharmacol, 48 (1995), 880-889.
- J. Chen, Y. Zhang, MB Kelz, C. Steffen, ES Ang, L. Zeng, et al., Induksi ti cyclin-gumantung kinase 5 dina hippocampus ku seizures electroconvulsive kronis:? Peran FosB, J Neurosci, 20 (2000), 8965-8971.
- CR Colby, K. Whisler, C. Steffen, EJ Nestler, sarta DW Self, tipe-spésifik sél Striatal overexpression of? FosB ngaronjatkeun incentive pikeun kokain, J Neurosci, 23 (2003), 2488-2493.
- D. Damez-Werno, Q. LaPlant, H. Sun, KN Scobie, DM Dietz, IM Walker, et al., pangalaman ubar epigenetically wilangan prima Fosb gén inducibility di beurit inti accumbens, J Neurosci, 32 (2012), 10267-10272.
- P. Dobrazanski, T. Noguchi, K. Kovary, CA Komarudin, PS Lazo, sarta R. Bravo, Duanana produk ti gén fosB, FosB jeung formulir pondok na, FosB / SF, nu activators transcriptional di fibroblasts, Mol Cell Biol, 11 (1991), 5470-5478.
- Kuring Ehrlich, J. Sommer, E. Canas, sarta EM Unterwald, mencit Periadolescent Témbongkeun ditingkatkeun? FosB upregulation di respon kana kokain jeung amphetamine, J Neurosci, 22 (2002), 9155-9159.
- D. Ferguson, N. Shao, J. Koo, J. Feng, V. Vialou, D. Dietz, et al., Salajengna generasi sequencing maké chip-seq highlights hiji peran penting pisan pikeun SIRT1 di plasticity emosi, Nu Ngarencana Papanggihan neurosains, Program No. 778.09, Society pikeun neurosains, New Orleans, LA, 2012.
- AM Graybiel, R. Moratalla, sarta HA Robertson, Amphetamine jeung kokain dipicuna aktivasina ubar-spésifik dina gén c-fos di compartments striosome-matrix jeung babagian limbic of striatum nu, Proc Natl Acad Sci AS, 87 (1990), 6912-6916.
- BA Grueter, AJ Robison, RL Neve, EJ Nestler, sarta RC Malenka, ? FosB differentially modulates inti accumbens fungsi jalur langsung jeung teu langsung, Proc Natl Acad Sci AS (pikeun némbongan).
- VL Hedges, S. Chakravarty, EJ Nestler, sarta RL Meisel, ? FosB overexpression dina accumbens inti ngaronjatkeun ganjaran seksual di hamsters Siria bikangna, Gén Brain Behav, 8 (2009), 442-449.
- N. Hiroi, JR Brown, CN Haile, H. Ye, kuring Greenberg, sarta EJ Nestler, Beurit mutan FosB: kaleungitan induksi kokain kronis protéin anu patali sareng Fos sareng sensitipitas anu ningkat kana psikomotor kokain sareng pangaruh anu nguntungkeun, Proc Natl Acad Sci AS, 94 (1997), 10397-10402.
- N. Hiroi, GJ Arék, JR Brown, H. Ye, F. Saudou, VA Vaidya, et al., peran penting dina gén fosB dina lampah molekular, sélular, sarta behavioral of seizures electroconvulsive kronis, J Neurosci, 18 (1998), 6952-6962.
- B. Hope, B. Kosofsky, SE Hyman, sarta EJ Nestler, Pangaturan éksprési gén mimiti saharita sarta AP-1 mengikat di accumbens beurit inti ku kokain kronis, Proc Natl Acad Sci AS, 89 (1992), 5764-5768.
- BT Hope, anjeunna Nye, MB Kelz, DW Self, MJ Iadarola, Y. Nakabeppu, et al., Induksi tina hiji komplek AP-1 lila-abadi diwangun ku dirobah protéin Fos-kawas dina otak ku kokain kronis sarta perlakuan kronis séjén, Neuron, 13 (1994), 1235-1244.
- HJ Jorissen, PG Ulery, L. Henry, S. Gourneni, EJ Nestler, sarta G. Rudenko, Dimerization jeung pasipatan DNA-beungkeutan faktor transkripsi? FosB, Biokimia, 46 (2007), 8360-8372.
- PW Kalivas na nd Volkow, The neural dasar kecanduan: a Patologi motivasi sarta pilihan, Am J Psychiatry, 162 (2005), 1403-1413.
- GB Kaplan, KA Leite-Morris, W. Fan, AJ Young, sarta MD Guy, Opiate sensitization induces ekspresi FosB /? FosB di prefrontal cortical, striatal na amygdala wewengkon otak, PLoS Hiji, 6 (2011), e23574.
- JA Kauer jeung RC Malenka, plasticity Synaptic na kecanduan, Nat blk Neurosci, 8 (2007), 844-858.
- MB Kelz, J. Chen, Carlezon Jr, WA, Jr, K. Whisler, L. Gilden, AM Beckmann, et al., Ekspresi faktor transkripsi? FosB dina uteuk ngawasaan sensitipitas mun kokain, Alam, 401 (1999), 272-276.
- A. Kumar, KH Choi, W. Renthal, nm Tsankova, DE Theobald, HT Truong, et al., remodeling Chromatin nyaéta mékanisme konci kaayaan plasticity kokain-ngainduksi di striatum, Neuron, 48 (2005), 303-314.
- Q. LaPlant na EJ Nestler, CRACKing kode histone: épék kokain dina struktur sareng fungsi kromatin, Horm Behav, 59 (2011), 321-330.
- KW Lee, Y. Kim, AM Kim, K. Helmin, AC Nairn, sarta P. Greengard, Wangunan déndritik tulang tonggong kokain-ngainduksi di D1 na D2 dopamin reséptor-ngandung neuron spiny sedeng di accumbens inti, Proc Natl Acad Sci AS, 103 (2006), 3399-3404.
- ML Lehmann sarta M. Herkenham, pengayaan Lingkungan confers stress resiliency mun eleh sosial ngaliwatan hiji cortex-gumantung jalur neuroanatomical infralimbic, J Neurosci, 31 (2011), 6159-6173.
- A. Levine, Y. Huang, B. Drisaldi, EA Griffin Jr, DD Pollak, S. Xu, et al., mékanisme molekular pikeun ubar gateway: parobahan epigenetic diprakarsai ku éksprési gén perdana nikotin ku kokain, Sci Transl Med, 3 (2011), 107ra109.
- AA Levine, Z. Guan, A. Barco, S. Xu, er Kandel, sarta JH Schwartz, CREB-mengikat protéin ngawasaan respon kana kokain ku acetylating histones di promoter fosB dina striatum mouse, Proc Natl Acad Sci AS, 102 (2005), 19186-19191.
- J. Li, Y. Sun, sarta J. Ye, Electroacupuncture nurun konsumsi alkohol kaleuleuwihan ngalibetkeun réduksi tina FosB /? Tingkat FosB di wewengkon otak nu patali ganjaran, PLoS Hiji, 7 (2012), e40347.
- HF Liu, WH Zhou, HQ Zhu, MJ Lai, sarta WS Chen, Microinjection sahiji M5 reséptor muscarinic antisense oligonucleotide kana VTA nyegah ekspresi FosB dina NAc jeung hippocampus of heroin sensitized beurit, Neurosci Bull, 23 (2007), 1-8.
- I. Maze, anjeunna Covington 3rd, DM Dietz, Q. LaPlant, W. Renthal, SJ Russo, et al., peran penting tina histone methyltransferase G9a di plasticity kokain-ngainduksi, Élmu, 327 (2010), 213-216.
- CA McClung na EJ Nestler, Pangaturan éksprési gén jeung kokain ganjaran ku CREB na? FosB, Nat Neurosci, 6 (2003), 1208-1215.
- CA McClung, PG Ulery, Li Perrotti, V. Zachariou, O. Berton, sarta EJ Nestler, ? FosB: a switch molekular pikeun adaptasi jangka panjang dina uteuk, Mol Brain res, 132 (2004), 146-154.
- J. McDaid, Buyung Dallimore, AR Mackie, sarta TC Napier, Parobahan pCREB accumbal na pallidal na FosB di beurit morfin-sensitized:? Correlations kalayan ukuran electrophysiological reséptor-evoked dina pallidum véntral, Neuropsychopharmacology, 31 (2006), 1212-1226.
- J. McDaid, MP Graham, sarta TC Napier, Methamphetamine-ngainduksi sensitization differentially alters pCREB na? FosB sapanjang circuit limbic otak mamalia, Mol Pharmacol, 70 (2006), 2064-2074.
- C. Mombereau, L. Lhuillier, K. Kaupmann, sarta JF Cryan, GABAB reséptor-positip blokade modulasi-ngainduksi sahiji sipat rewarding nikotin anu pakait sareng ngurangan di accumbens inti? Akumulasi FosB, J Pharmacol exp Ther, 321 (2007), 172-177.
- R. Moratalla, B. Elibol, M. Vallejo, sarta AM Graybiel, parobahan jaringan-tingkat dina ekspresi inducible protéin Fos-Jun di striatum salila perlakuan kokain kronis sarta ditarikna, Neuron, 17 (1996), 147-156.
- Ji Morgan jeung T. Karana, gén Geura-mimiti: sapuluh taun di, Tren Neurosci, 18 (1995), 66-67.
- DL Müller sarta EM Unterwald, reséptor dopamin D1 modulate? FosB induksi dina striatum beurit sanggeus administrasi morfin intermittent, J Pharmacol exp Ther, 314 (2005), 148-154.
- J. Muschamp, C. Nemeth, A. Robison, E. Nestler, sarta W. Carlezon Jr, ? FosB ngaronjatkeun épék rewarding of kokain bari ngurangan efek pro-depressive tina agonist reséptor kappa-opioid U50488, Biol Psychiatry, 71 (2012), 44-50.
- Y. Nakabeppu sarta D. Nathans, A formulir truncated kajadian sacara alami tina FosB nu nyegah aktivitas transcriptional Fos / Jun, Cell, 64 (1991), 751-759.
- EJ Nestler, dadasar molekular jangka panjang plasticity kecanduan kaayaan, Nat blk Neurosci, 2 (2001), 119-128.
- EJ Nestler, mékanisme Transcriptional tina kecanduan: peran FosB?, Philos Trans Sunda Soc Lond B Biol Sci, 363 (2008), 3245-3255.
- EJ Nestler, MB Kelz, sarta J. Chen, ? FosB: a mediator molekular neural jangka panjang sarta plasticity behavioral, Brain res, 835 (1999), 10-17.
- SD Norrholm, JA Bibb, EJ Nestler, CC Ouimet, JR Mekarwangi, sarta P. Greengard, proliferasi kokain-ngainduksi of spines déndritik di accumbens intina nyaeta gumantung aktivitas cyclin-gumantung kinase-5, Neurosains, 116 (2003), 19-22.
- Anjeunna Nye, B. Hope, M. Kelz, M. Iadarola, sarta E. Nestler, studi Pharmacological tina pangaturan FOS nu patali kronis antigen induksi ku kokain dina striatum na inti accumbens, J Pharmacol exp Ther, 275 (1995), 1671-1680.
- Anjeunna Nye na EJ Nestler, Induksi ti kronis antigén Fos-patali dina uteuk beurit ku administrasi morfin kronis, Mol Pharmacol, 49 (1996), 636-645.
- P. Olausson, JD Jentsch, N. Tronson, RL Neve, EJ Nestler, sarta JR Mekarwangi, ? FosB dina accumbens inti ngatur kabiasaan instrumental dahareun-bertulang jeung motivasi, J Neurosci, 26 (2006), 9196-9204.
- MC Peakman, C. Colby, Li Perrotti, P. Tekumalla, T. Carle, P. Ulery, et al., Inducible, uteuk ekspresi wilayah-spésifik of a mutant négatip dominan tina c-Jun di mencit transgenik nurun sensitipitas mun kokain, Brain res, 970 (2003), 73-86.
- Li Perrotti, CA Bolan ~ OS, KH Choi, SJ Russo, S. Edwards, PG Ulery, et al., ? FosB accumulates dina populasi sél GABAergic dina buntut posterior wewengkon tegmental véntral sanggeus perlakuan psychostimulant, Eur J Neurosci, 21 (2005), 2817-2824.
- Li Perrotti, Y. Hadeishi, PG Ulery, M. Barrot, L. Monteggia, RS Duman, et al., Induksi ti? FosB dina struktur otak nu patali ganjaran sanggeus stress kronis, J Neurosci, 24 (2004), 10594-10602.
- Li Perrotti, RR Weaver, B. Robison, W. Renthal, I. Maze, S. Yazdani, et al., pola béda tina? FosB induksi dina otak ku ubar ti nyiksa, Synapse, 62 (2008), 358-369.
- EM Pich, SR Pagliusi, M. Tessari, D. Talabot-Ayer, R. Hooft van Huijsduijnen, sarta C. Chiamulera, substrat neural umum pikeun sipat adiktif nikotin jeung kokain, Élmu, 275 (1997), 83-86.
- KK Pitchers, KS Frohmader, V. Vialou, E. Mouzon, EJ Nestler, Bungbulang Lehman, et al., ? FosB dina accumbens inti mangrupa kritik keur efek tina ganjaran seksual reinforcing, Gén Brain Behav, 9 (2010), 831-840.
- W. Renthal, TL Carle, I. Maze, anjeunna Covington 3rd, HT Truong, I. Alibhai, et al., ? FosB mediates desensitization epigenetic tina gén c-fos sanggeus paparan amphetamine kronis, J Neurosci, 28 (2008), 7344-7349.
- W. Renthal, A. Kumar, G. Xiao, M. Wilkinson, anjeunna Covington 3rd, I. Maze, et al., Analisis génom-lega pangaturan chromatin ku kokain mangka peran pikeun sirtuins, Neuron, 62 (2009), 335-348.
- W. Renthal, I. Maze, V. Krishnan, anjeunna Covington 3rd, G. Xiao, A. Kumar, et al., Histone deacetylase 5 epigenetically ngawasaan adaptations behavioral kana rangsangan émosional kronis, Neuron, 56 (2007), 517-529.
- Te Robinson sarta B. Kolb, plasticity struktural pakait sareng paparan ka ubar tina nyiksa, Neuropharmacology, 47 (2004), 33-46.
- AJ Robison na EJ Nestler, mékanisme Transcriptional na epigenetic tina kecanduan, Nat blk Neurosci, 12 (2011), 623-637.
- AJ Robison, V. Vialou, M. Mazei-Robison, J. Feng, S. Kourrich, M. Collins, et al., réspon behavioral jeung struktural pikeun kokain kronis merlukeun hiji loop feed-maju ngalibetkeun? FosB na CaMKII dina intina accumbens cangkang, J Neurosci (pikeun némbongan).
- SJ Russo, MB Wilkinson, MS Mazei-Robison, DM Dietz, I. Maze, V. Krishnan, et al., Nuklir faktor B signalling ngatur morfologi neuronal jeung kokain ganjaran, J Neurosci, 29 (2009), 3529-3537.
- HJ Shaffer na GB Eber, progression temporal gejala kokain gumantungna dina Survey Comorbidity Nasional AS, Kecanduan, 97 (2002), 543-554.
- T. Shippenberg jeung W. Rea, Sensitization ka épék behavioral of kokain: modulasi ku dynorphin na kappa-opioid agonists reséptor, Pharmacol Biochem Behav, 57 (1997), 449-455.
- J. Mekarwangi, W. Lynch, H. Sanchez, P. Olausson, E. Nestler, sarta J. Bibb, Inhibisi Cdk5 dina accumbens inti ngaronjatkeun locomotor-ngaktipkeun sarta incentive-motivational balukar kokain, Proc Natl Acad Sci AS, 104 (2007), 4147-4152.
- SL Teegarden na TL Bale, Nurun di sering dipake tinimbang dietary ngahasilkeun ngaronjat emotionality sarta résiko keur kambuh dietary, Biol Psychiatry, 61 (2007), 1021-1029.
- SL Teegarden, EJ Nestler, sarta TL Bale, alterations? FosB-dimédiasi di dopamin signalling anu dinormalisasi ku diet-gajih tinggi palatable, Biol Psychiatry, 64 (2008), 941-950.
- PG Ulery, G. Rudenko, sarta EJ Nestler, Pangaturan? FosB stabilitas ku fosforilasi, J Neurosci, 26 (2006), 5131-5142.
- PG Ulery-Reynolds, MA gulang, V. Vialou, SJ Russo, sarta EJ Nestler, Fosforilasi of? FosB mediates stabilitas taun vivo, Neurosains, 158 (2009), 369-372.
- V. Vialou, J. Feng, AJ Robison, SM Ku, D. Ferguson, KN Scobie, et al., Faktor respon sérum sarta unsur respon camp protéin mengikat duanana diperlukeun pikeun induksi kokain of? FosB, J Neurosci, 32 (2012), 7577-7584.
- V. Vialou, I. Maze, W. Renthal, QC LaPlant, El Watts, E. Mouzon, et al., Faktor respon sérum promotes resilience ka stress sosial kronis ngaliwatan induksi ti? FosB, J Neurosci, 30 (2010), 14585-14592.
- V. Vialou, AJ Robison, QC Laplant, anjeunna Covington 3rd, DM Dietz, yn Ohnishi, et al., ? FosB di sirkuit ganjaran otak mediates resilience kana réspon setrés, jeung antidepressant, Nat Neurosci, 13 (2010), 745-752.
- DL Wallace, V. Vialou, L. Rek, TL Carle-madang, S. Chakravarty, A. Kumar, et al., Pangaruh? FosB dina intina accumbens on kabiasaan nu patali ganjaran alam, J Neurosci, 28 (2008), 10272-10277.
- Y. Wang, TI Cesena, Y. Ohnishi, R. Gatotkaca-Caplan, V. Lam, PD Kirchhoff, et al., screening molekul leutik nangtukeun régulator sahiji faktor transkripsi? FosB, ACS Chem Neurosci, 3 (2012), 546-556.
- M. Werme, C. Messer, L. Olson, L. Gilden, P. Thorén, EJ Nestler, et al., ? FosB ngatur kabayang jalan, J Neurosci, 22 (2002), 8133-8138.
- CA Winstanley, RK Bachtell, DE Theobald, S. Laali, TA Héjo, A. Kumar, et al., Ngaronjat impulsivity salila ditarikna ti kokain timer administrasi: peran pikeun FosB di cortex orbitofrontal?, Cereb Cortex, 19 (2009), 435-444.
- CA Winstanley, TA Héjo, DE Theobald, W. Renthal, Q. LaPlant, RJ DiLeone, et al., ? FosB induksi dina cortex orbitofrontal potentiates locomotor sensitization sanajan attenuating nu disfungsi kognitif disababkeun ku kokain, Pharmacol Biochem Behav, 93 (2009), 278-284.
- CA Winstanley, Q. LaPlant, DE Theobald, TA Héjo, RK Bachtell, Li Perrotti, et al., ? FosB induksi dina cortex orbitofrontal mediates kasabaran ka disfungsi kognitif kokain-ngainduksi, J Neurosci, 27 (2007), 10497-10507.
- J. Yen, rm Hikmah, I. Tratner, sarta IM Verma, Hiji formulir spliced alternatif tina FosB mangrupakeun regulator négatip tina aktivasina transcriptional jeung transformasi ku protéin Fos, Proc Natl Acad Sci AS, 88 (1991), 5077-5081.
- ST Young, lj Porrino, sarta MJ Iadarola, Kokain induces striatal c-fos-immunoreactive protéin via reséptor dopaminergic D1, Proc Natl Acad Sci AS, 88 (1991), 1291-1295.
- V. Zachariou, CA Bolanos, DE Selley, D. Theobald, MP Cassidy, MB Kelz, et al., Hiji peran penting pisan pikeun? FosB dina intina accumbens dina peta morfin, Nat Neurosci, 9 (2006), 205-211.