NdinguJ J ukusebenzisa iziyobisi gwenxa. 2014 Aug 1: 1-10.
Abstract
I-FosB ekhutshelweyo ikhutshelwa kwimimandla emininzi yobuchopho emva kokuvezwa iziyobisi okuphindaphindiweyo. Olu lwazi lunokwenzeka, ubuncinci kwinxalenye, luxanduva lwezinto eziphantsi kwesiyobisi, uphazamiseko apho umgaqo wolwaziso lobuhlobo uthathwa njengobalulekile. Kolu hlaziyo, sichaza kwaye sixoxa ngendima ecetywayo ye-ΔFosB kunye neziphumo zezinto ezifunyaniswe mva nje. Inkcazo ye-ΔFosB ibonisa ukwahluka kuxhomekeka kwinto elawulwayo, ibonisa ukungqinisisa okungingqini kwengingqi yeziyobisi ezahlukeneyo. Le nto yokukhutshelwayo iyaqondwa ukuba isebenze ngokusebenzisana neeproteni zosapho lakwaJun kunye nokwenziwa kweeproteni ze-activator-1 (AP-1). Nje ukuba i-AP-1 i-complexes isungulwe, uninzi lweendlela zeemolekyhule ziqalisiwe, zibangela ukuguqulwa kwemfuza, imolekyuli kunye nolwakhiwo. Uninzi lwezi nguqu zimolekyuli ezichongiweyo ngoku zinxulumana ngokuthe ngqo notshintsho lomzimba kunye nokuziphatha okubonakalayo emva kokuvezwa kweziyobisi okungapheliyo. Ukongeza, i-ΔFosB induction ithathwa njenge-biomarker yovavanyo longenelelo ngoncedo olunokubakho lonyango.
IINKCUKACHA:
Iziyobisi DeltaFosB; i-biomarker; i-epigenetics; ukukhutshelwa; unyango
;