Ngaba Iziphazamiso Zokuxhalaba Ziphelele Engqondweni?
I-ScienceDaily (ngoMeyi 12, 2008) Ukusebenzisa i-photon-emission emission computed tomography (SPECT), abaphandi baseNetherlands baye bakwazi ukubona umahluko we-biochemical ebuchosheni babantu abanengxaki yokuxhalaba ngokubanzi (ekwabizwa ngokuba yi-social phobia), banikezela ubungqina besizathu sebhayoloji ekudala sirhanelwa. ukungasebenzi.
Uphononongo luthelekisa ukuxinana kwezinto ze-serotonin kunye ne-dopamine neurotransmitter iinkqubo kwiingqondo zabantu abali-12 abafunyaniswa benoxinzelelo lwentlalontle, kodwa ababengakhange bathathe amayeza ukuyinyanga, kunye neqela elilawulayo labantu abanempilo ye-12 abaye bahambelana nesondo kunye nobudala.
Omabini la maqela atofwa ngekhompawundi yeradioactive edityaniswa nezinto zeserotonin yobuchopho kunye neenkqubo ze-dopamine. Nje ukuba ilawulwe, i-radiotracer iveze utshintsho olusebenzayo kwezi nkqubo ngokulinganisa ukubotshwa kweradioactive kwithalamus, midbrain kunye neepons (ezaziwa ukuba zisetyenzwa yi-serotonin) nakwi-striatum (eyaziwa ngokuba yenziwa yi-dopamine). Umsebenzi otshintshileyo wokuthathwa kule mimandla ubonise inqanaba elikhulu lomsebenzi ophazamisekileyo.
"Uphononongo lwethu lubonelela ngobungqina obuthe ngqo bokubandakanyeka kwenkqubo yengqondo ye-dopaminergic kwingxaki yokuxhalaba kwezentlalo kwizigulana ezazingenalo ukuvezwa kwamayeza kwangaphambili., "Utshilo uDkt. van der Wee, MD, Ph.D., kwisebe lezengqondo kunye neLeiden Institute for Brain and Cognition kwiYunivesithi yaseLeiden Medical Centre, uLeiden (kwaye ngaphambili kwi-Rudolf Magnus Institute of Neuroscience, iYunivesithi yezoNyango Iziko e-Utrecht, eNetherlands). "Kubonisa ukuba ukuxhalaba kwentlalo kunomzimba, ukuxhomekeka kwengqondo."
I-Serotonin kunye ne-dopamine (i-neurotransmitters, okanye izinto ezinoxanduva lokuhambisa imiqondiso ukusuka kwenye i-neuron ukuya kwenye) zisebenza kwii-receptors engqondweni. Ukuba ii-neurotransmitters azikho kulungelelwano, imiyalezo ayinakungena engqondweni ngokufanelekileyo. Oku kunokutshintsha indlela ingqondo esabela ngayo kwiimeko eziqhelekileyo zentlalo, ekhokelela kwixhala.
Olunye uphando lwe-neuroimaging lubonise ukungaqhelekanga kwi-glucose kunye nokusetyenziswa kwe-oksijini engqondweni, ngokutsho kuka-van der Wee, owalatha kwi-causality njengomba owongezelelweyo. “Uninzi lwabantu ababandakanyekayo kwezi zifundo zangaphambili bebesaziwa ukuba sele benengxaki, ngoko asazi ukuba izinto ezingaqhelekanga bezikhona na ngaphambi kokuqala kwesi sifo,” utshilo.
Ngokusekwe kuphononongo lwangaphambili, abanye abaphandi bacebise ukuba ukuphazamiseka koxinzelelo lwentlalo sisiphumo sokuhlangana phakathi kofuzo okanye obufunyenwe sesichengeni sebhayoloji kunye nokusingqongileyo. Uphando lwakutsha nje lubonise ukuba ukuphazamiseka kwengxaki yentlalo kunokunxulumana nokungalingani kwe-neurotransmitter serotonin. Eli lixesha lokuqala inkqubo ye-dopaminergic yobuchopho ivavanywa ngokuthe ngqo.
"Nangona akukho ziphumo zithe ngqo kunyango ngenxa yolu phononongo okwangoku, bobunye ubungqina obubonisa ukungahambi kakuhle kwezinto eziphilayo, okunokukhokelela kwiindlela ezintsha zonyango kunye nokuqonda imvelaphi yesi sifo," utshilo uGqr van der Wee. .
NgokweZiko leSizwe leMpilo yeNgqondo, ukuphazamiseka kokuxhalaba kwezentlalo kuchaphazela abantu abadala baseMelika abamalunga ne-15 yezigidi kwaye yeyona nto yesithathu ixhaphakileyo ukuphazamiseka kwengqondo eUnited States, emva kokudakumba kunye nokuxhomekeka etywaleni. Into ebalulekileyo yokuphazamiseka kukoyika ukuvavanywa ngabanye, ngokulindela ukuba uvavanyo olunjalo luya kuba lubi kwaye lube neentloni. Idla ngokuqhuba ikhosi engapheliyo nengapheliyo kwaye kaninzi ikhokelela ekukhuleni kotywala kunye nokudakumba. Esi sifo sihlala sivela ekufikiseni okanye ebuntwini obukhulu, kodwa singenzeka nanini na, kubandakanya nobuntwana.
Ababhali-bambisene bokufunda baquka uJ. Frederieke van Veen, u-Irene M. van Vliet, uHerman G. Westenberg, iSebe leNgqondo yengqondo; kunye noHenk Stevens, uPeter P. van Rijk, iSebe leNuclear Medicine, bonke abavela kwi-Rudolf Magnus Institute of Neuroscience, i-University Medical Centre Utrecht, Utrecht, The Netherlands.
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Isalathiso seJenali:
1. NJ van der Wee, JF van Veen, H. Stevens, IM van Vliet, PP van Rijk, HG Westenberg. Ukunyuka kweSerotonin kunye neDopamine Transporter Ukubophelela kwi-Psychotropic Medication-Naive Patients with Generalized Social Anxiety Disorder Eboniswe yi-123I- (4-Iodophenyl) -Tropane SPECT. Ijenali yeNuclear Medicine, ngo-2008; 49 (5): 757 DOI: 10.2967/jnumed.107.045518
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