Ukuphuhliswa kobuXhoxiso be-Sexual middle among Men and Older Men (2014)

Iimpendulo: Olunye uphononongo olubonisiweyo Amanqanaba e-gawd-awve e-ED emadodeni:

Ukuxhaphaka kwe-ED kumadoda ane-40-51 iminyaka kwakuyi-58.6%

Abaphandi abaze banike nkcazo ilungileyo, ngaphandle kokujonga ukuba amaxabiso e-ED akhwela kubafana. Njengakwizifundo zangaphambili, abaphandi khange babuze malunga nokusetyenziswa kwe-Intanethi.

Ukususela kwisifundo:

Nangona kunjalo, sikwafumanise ukungafani kolu hlanga. Ukuxhaphaka kwe-ED kumadoda ane-40-51 iminyaka yayiyi-58.6%, ekubonakala ngathi yahlukile kwidatha kuphando oludlulileyo lwesifo (esusela kwi-2% ukuya kwi-39% emadodeni aphakathi kweminyaka ye-40 kunye ne-50 iminyaka [22]. Tukwanda kwe-ED kwi-40-51 iminyaka yeqela inokuchazwa ngolu hlobo: okokuqala, Ubungqina obuqhubekayo ngakumbi kwiminyaka yakutshanje bubonakalisile ukuba imeko ye-ED iyanda kakhulu kumadoda amancinci nakwiminyaka ephakathi [23], [24]; Okwesibini, umda omkhulu we-ED ethambileyo (i-53.5% kuyo yonke, engaboniswanga kwiziphumo) eboniswe kule cohort, edla ngokugqalwa kuqheliselo lweklinikhi. [25]; Okwesithathu, iimpembelelo zaseTshayina zenkcubeko kunye nezentlalo zinokubangela ukwanda kwe-psychogenic ED eboniswe kumadoda aphakathi [26], ngelixa amanqaku e-IIEF-5 engabandakanyi i-psych psych [26], [27]. TApha bekungekho manyano lubalulekileyo phakathi kwe-ED, dyslipidemia kunye neendlela zokuphila,

Kwakhona, abaniki zinkcazo zilungileyo, ngaphandle kokujonga ukuba amazinga e-ED akhwela kubafana. Isizathu sesibini (ubumnene be-ED obugqithileyo kuqheliselo lweklinikhi) alukho semthethweni njengoko uninzi lwezifundo zangaphambili bezisekwe kumanani oluntu kwaye zibandakanywa ne-ED emdaka. Okothusayo kukuba i-ED yayingadibananga nezinto zendlela yokuphila okanye uvavanyo lwegazi.

Ipapashwe: ngoMatshi 25, 2014 INGXELO: 10.1371 / journal.pone.0092794

Yan-Ping Huang, Bin Chen imeyile, Ping Ping, Hong-Xiang Wang, Kai Hu, Hao Yang, Tao Zhang, Tan Feng, Yan Jin, Yin-Fa Han, Yi-Xin Wang, Yi-Ran Huang

Abstract

iinjongo

Ukuvavanya ukusebenza kwe-erectile kumadoda aphakathi kunye nabadala ngemeko ye-asexility kunye nokuqhubeka nokuhlalutya izizathu zabo ezithile zale meko.

Izifundo kunye neendlela

Amadoda ayenemizamo eqhelekileyo yokulala ngesondo (ixesha lokulala ngesondo≥1 ixesha ngenyanga) ayehlelwa kwi-erectile dysfunction (ED), ngokumodareyitha ngokuqatha kwi-ED kunye ne-non-ED ngokwe-Index yeHlabathi ye-Erectile Function-5, kunye namadoda angenalo ulwabelana ngesondo. iinzame zobuncinci beenyanga ze-6 zachazwa njengezinesimo sokusebenza. Izinto zomngcipheko ezinxulunyaniswa ne-ED zaqokelelwa kwisampulu yamadoda amaTshayina angama-1,531 aneminyaka eyi-40 ukuya kwi-80 iminyaka, kunye nezizathu zokunikwa kwengxelo ngokusebenza gwenxa kwabhalwa kwisexual cohort ngokukodwa. Uhlalutyo oluqhathanisayo kunye neemodeli zokuphinda zenziwe phakathi kwala maqela.

iziphumo

Amanqanaba okwanda kwe-ED kunye ne-asexeness status yi-49.9% kunye ne-37.2%. Iqela lesimo se-asexeness lalinezinto eziphezulu zomngcipheko kune-moderate ukuya kwiqela le-ED ngokuhambelana nobudala (i-ageN65, uhlengahlengiso lokulinganisa okungafunekiyo (OKANYE I17.69 ngokuchaseneyo (iV. 7.19), isifo seswekile (kraca OKANYE: 2.40 Vs. 2.36) kunye noxinzelelo lwegazi (kraca OKANYE: 1.78 Vs. 1.72). Izizathu ezichaziweyo zesimo se-asexourse yi "erectile nobunzima" (52.9%), "andikhathali ngesondo" (53.5%) "," akusafuneki ukuba neentlobano zesini ngeli xesha "(47.7%)," uxinzelelo olukhulu " (44.4%), "ukukhathala kakhulu" (26.3%) kunye "nokuhambisa isitho sokuphulula amalungu esondo" (26.9%).

izigqibo

Amadoda ane-asexual status ahlupheka zizinto ezinobungozi obuphezulu be-ED kunamadoda ane-ED ukuya kumgangatho ophakathi. Uninzi lwale meko inokusetyenziswa njenge-ED epheleleyo, nangona izizathu zekamva lethutyana zibandakanya isimo sengqondo kunye nezinto onomdla kuzo, amaqabane ezesondo kunye nokuziphulula amalungu esini.

Amanani

Citation: U-Huang YP, u-Chen B, u-Ping P, u-Wang HX, u-Hu K, et al. (2014) Uphuhliso lobuNtu phakathi kwabaDala kunye naMadoda aDala. I-PloS ONE 9 (3): e92794. doi: 10.1371 / ijenali.pone.0092794

umhleli: UAlice YW Chang, Isibhedlele saseKaohsiung Chang Gung Memorial, eTaiwan

I funyenwe: Oktobha 30, 2013; Zamkelwa: NgoFebruwari 26, 2014; Yashicilelwe: Matshi 25, 2014

Copyright: © 2014 Huang et al. Eli linqaku lokufikelela ngokuvulekileyo elihanjiswe phantsi kwemiqathango ye Ilayisenisi yeCreation Commons Licribution, evumela ukusetyenziswa, ukuhanjiswa, nokuvelisa okungahambisani naluphi na uhlobo, ukuba unobumba bokuqala kunye nomthombo baxelwe.

Inkxaso: Olu phononongo luxhaswe sisibonelelo esivela kwi-National Natural Science Foundation yase China (N. 81270741). IKomishini yezeNzululwazi nobuChwepheshe yeProjekthi kaMasipala waseShanghai (Nombolo 08411951700). Abaxhasi babengenandima kuyilo lokufunda, ukuqokelelwa kwedatha kunye nohlalutyo, isigqibo sokupapasha, okanye sokulungiselela ukubhalwa.

Injongo yokunyanzela: Ababhali baye bavakalisa ukuba akukho mfuno ekhuphisanayo.

intshayelelo

Ngokuphuhliswa koluntu kunye nenkqubo yokwaluphala, ingqalelo yezonyango kunye neenkonzo ezinxulumene nomsebenzi wesondo ziyanda, kwaye abantu abadala abaphakathi kunye nabantu abadala zezona zijolise kubantu abaninzi kwizifundo ezininzi zokuphanda nokunyanga iingxaki zesondo. Ukungasebenzi kakuhle kwe-Erectile dysfunction (i-Ed) yeyona ngxaki ixhaphakileyo ngokwesini exutyushwa sisininzi esikhulayo sezifundo kwihlabathi liphela, kodwa kukho ulwazi olunqongopheleyo lwesimo se-asexeness esingahluka kwi-ED kwiimeko zengqondo nezomzimba. Ngokuchasene nemeko ye-asexeness esisigxina ekhathaza i-2-3% yamadoda kwaye ayichazwanga njengosiphazamiso [1], [2]Isimo sokusebenza ngokwesondo sinokuchazwa njengenqanaba lethutyana okanye elingenakuphikiswa kumadoda amadala kunye nabantu abadala ababenokwabelana ngesondo ngaphambili kodwa ngoku bakwinqanaba lokungathandani malunga nokuba neentlobano zesini nomntu ongatshatanga naye. Rhoqo, iingcali kwezempilo zithatha ingqalelo yokuba imeko ye-asexourse inxulumene nezinto ezibandakanya ingqondo, inkolo, amaqabane abelana ngesondo kunye nobungqingili, kwaye bayasilela ukuwavavanya la madoda asexual, achazwa njengabangenabudlelane bokwabelana ngesondo ixesha elide, ngokusebenzisa i-Index yeHlabathi. woMsebenzi we-Erectile (IIEF) ukumisela i-ED. Njengoko kungekho zindululo zinemigangatho yokuvavanya imeko ye-asexeness, indlela yokuqinisekisa umsebenzi we-erectile oyinyani kunye nokuphononongwa kwezizathu ezithile zomsebenzi kwi-cohort kubaluleke kakhulu. Kodwa ukuza kuthi ga ngoku, akukho datha iphelele, inabameli kunye nedatha esekwe ekuhlaleni yokunceda abagqirha baqonde imeko ye-asexeness. I-Shanghai yakhokela kwinkqubo yokwaluphala kwaye yaba yindawo yokuqala enesakhiwo esidala sabemi e-China. Inani labantu abangaphezu kwe-65 liya kufikelela kwincopho yezigidi ezine ngonyaka we-2025, emva koko bahlale i-29% yabemi bebonke [3]. Yiyo loo nto ukwaluphala kwabantu eShanghai kungathathelwa ingqalelo njengommeli welizwe lonke, kwaye inani lobudoda linokuba sisampulu efanelekileyo yokufunda ukungasebenzi kakuhle ngokwesondo. Iinjongo zolu fundo lwenziwe ngobuninzi babafundi olwenzelwe kakuhle yayikukuqinisekisa umsebenzi we-erectile kubantu abadala kunye nabadala abanesimo esisexesikalini ngokuthelekisa imeko ye-asexeness kunye ne-ED kunye ne-non-ED njengoko kuchaziwe ekliniki, kunye nakwimeko yentlalo -Imilo, ikliniki kunye neendlela zokuphila kunye nokuphononongwa ngakumbi kwezizathu ezithile zomsebenzi.

Impahla nenkqubo

UkuFunda kwabantu

Olu phando luphande ngesondo kunye nenqanaba lempilo kumadoda aphakathi kunye namadoda amadala ukusuka kwi-40 ukuya kwi-80 yeminyaka yobudala. Uluntu olungamashumi amabini anesibini lwahlukaniswa njengendawo ephakathi edolophini, indawo engaphandle kwedolophu kunye necala lendawo yedolophu ngabaphengululi. Uluntu lwesixhenxe lwaqinisekiswa ukuba luphonononge ngendlela yesampulu ehlelelekileyo yesampulu. Abathathi-nxaxheba abaphuma kwiindawo ezikhethwe ngokungacwangciswanga babandakanywa ngeeposti. Ngexesha lesigaba sophando (ukusuka kwi-2008 ukuya kwi-2011), amadoda ayenakho ukuzikhathalela kwaye ehlala esixekweni ixesha elingaphezu konyaka. Izifundo ezazinengxaki yokuphuhliswa kokuzalwa kunye / okanye ukukhubazeka komzimba, izifo ezinzulu (okt isifo esixineneyo senhliziyo kunye / okanye ukuphazamiseka kwengqondo, ukuphazamiseka kwengqondo kunye / okanye ukungasebenzi kakuhle kwengqondo) kunye nokuziqhelanisa nobungqingili okanye ukubekeka ecaleni. Zonke ezi zinto ziphazamisayo zaqinisekiswa yingxelo yakho, uphononongo irekhodi lwezonyango kunye nodliwanondlebe. Kubaphenduli abafanelekileyo be-1,720, i-1,591 igqibe isiseko kwenkqubo esekhaya. Kwimpendulo yasekuqaleni ye-1,591 kuvavanyo olusisiseko, i-60 ayifakwanga njengedatha ephikisanayo okanye engaphelelanga, eshiye amadoda e-1,531 efanelekile izibalo.

Amanyathelo asetyenzisiweyo

Iprothokholi yensimu yaqulunqwa ngokomfuziselo weMassachusetts Indoda yokuGuga [4]. Ngokufutshane, ingcali eqeqeshiweyo yecandelo / iphlebotomist ityelele isifundo ngasinye kwiZiko leNkonzo yoLuntu okanye kwikhaya lakhe ngokweeprotokholi zovavanyo oluqhelekileyo olwenzelwe umsebenzi omkhulu [5], yaqokelela idatha yeenombolo zabantu, yalawulwa ngemibuzo yempilo ngokubanzi kunye nezixhobo zokuhlola imeko yezesondo, kwaye yafumana iisampulu zegazi zokuzila. Olu phononongo lufumene ukuvunywa kwebhodi yeziko yokuhlola (iSibhedlele iRenji, iShanghai. N. RJLS2008175), nemvume ebhaliweyo yanikwa ngabo bonke abathathi-nxaxheba. Yonke idatha eqokelelweyo yafakwa kwindawo yokugcina idatha esekwe kusetyenziswa inkqubo ye-ACCESS kunye nomodyuli osebenzayo, onokufumaneka kuzo zombini iKhomishini yezeSayensi kunye neTekhnoloji yeShanghai kunye neZiko laseShanghai leAndrology.

Imilinganiselo yoxinzelelo lwegazi ezintathu yafunyanwa. Isalathiso sobunzima bomzimba (BMI) sabalwa ngokomlinganiso olinganisiweyo ngeekhilogrem zahlulwe ngobude obulinganisiweyo kwiimitha eziphindwe kabini kwaye zahlulwa ngokodidi lwe-World Health Organisation (WHO) [6]: ukukhuluphala (≥25 kg / m2) okanye hayi (<25 kg / m2). Imilinganiselo ye-Waist circumference (WC) isetyenziswe njengenyathelo le-adiposity esembindini, kwaye yahlelwa ngokwamacandelo amabini: ukutyeba kakhulu (≥90 cm) okanye hayi (<90 cm)) [7].

Ngokumalunga novavanyo lwesimo sesondo, iphepha lemibuzo oluzimele geqe malunga nesondo lanikwa isifundo ngasinye ukuze sigqitywe ngasese. Kwiphepha elisisiseko lemibuzo yezokwabelana ngesondo amadoda azihlukanise ngokwamanqanaba amabini: ukungabelani ngesondo okanye ukuba neentlobano zesini kwiinyanga ezi-6 ezidlulileyo. Ifom ye-5 yento ye-Index ye-Erectile Function (IIEF-5) yabonelelwa ngasese kwizifundo ezinesondo rhoqo ngesondo ≥1 ixesha ngenyanga ngenyanga kwiinyanga ze-6 ezidlulileyo, kwaye babekwa ngokwamanqanaba amathathu: i-non-ED (IIEF-5≥22), ubumnene be-ED (21≥IIEF-5≥12) kunye nokumodareyitha ngokuqatha kwi-ED (11≥IIEF-5≥5). Abaphenduli ngaphandle kokuzama ukuba neentlobano zesini ubuncinci iinyanga ze-6 zachazwa njengezinesimo sokusebenza. Ulwazi olunxulumene nemeko ye-asexuality, kubandakanya iqabane elingatshatanga naye (“ongatshatanga, ongumhlolokazi, oqhawule umtshato okanye ohlukanisiweyo” kunye “nobudlelwane obuphathelele kwezesondo”), umdla wezesondo ("abakukhathaleli ubuni ngesondo '), iingxaki ze-erectile (“ ubunzima be-erectile ”), ezesondo. Izimo zengqondo ("akusafuneki ukuba neentlobano zesini okwangoku"), uxinzelelo lwentlalo nobomi ("uxinzelelo olukhulu", "ukukhathala okukhulu" kunye "nolwaneliseko lobomi obuphantsi") kunye ne-masturbation ("eurbation eqhelekileyo" kunye "nokuhlanjwa kwamalungu omzimba ngokungaqhelekanga" ), zaqokelelwa ngokwahlukeneyo kubemi. Ekugqibeleni, izizathu ezichazayo zesimo se-asexities zakhutshwa kulwazi oluqokelelweyo lodliwano-ndlebe.

Idatha evela kudliwanondlebe olusisiseko yayisetyenziselwa ukuvavanya iimeko zobomi ezinomdla. Abathathi-nxaxheba babuzwa malunga nokuzivocavoca rhoqo kwiminyaka ye-5 eyadlulayo ("rhoqo" yachazwa ubuncinci kanye ngeveki, ngaphezulu kweenyanga ze-3 ngokuqhubekayo) [8]. Izifundo zesiselo esisiko esenziwa ngokwesiko siqikelelwa kukuzixela ngokwazo kusetyenziswa ifomula kaKhavari noFarber [9]. Ukuchazwa kwecuba lokutshaya kwaqinisekiswa ngokwenziwa kwengxelo, kwaye abo batshayayo ngoku bachazwa ngokungathi bayatshaya ngexesha lophando kwaye babetshaya ngaphezulu kwecuba le-100 ebomini babo [10]. Ukuselwa kweti yetiyitha kuvavanywe ngemibuzo ebuzwa rhoqo kule minyaka ingama-5 idlulileyo kwaye kwahlulwa ngokwamacandelo amachiza ("rhoqo" kwachazwa okungenani kanye ngemini, ngaphezulu konyaka u-1 ngokuqhubekayo).

Ukuqinisekisa ezi ziphumo zesifo esinganyangekiyo esizichazayo, sisebenzise iindlela ezahlukeneyo kubandakanya ukujonga irekhodi lonyango, uphononongo lwengxelo yezifo, udliwanondlebe ngomnxeba, okanye amaphepha emibuzo ongezelelweyo. Uxinzelelo lwegazi kwisiseko esisiseko kwaboniswa ukuba enye okanye ezingaphezulu kwezi meko zilandelayo ziye zahlangatyezwa: i-1) umxholo oxeliweyo usebenzise unyango lwe-antihypertensive; I-2) uxinzelelo lwegazi lwe-systolic yegazi ≥140 mmHg okanye uxinzelelo lwegazi ast90 mmHg [11]. I-Dyslipidemia yachazwa njenge-serum iyonke cholesterol≥5.72 mmol / L; kunye / okanye triglycerides≥1.70 mmol / L; kunye / okanye i-density low lipoprotein cholesterol≥3.64 mmol / L; kunye / okanye ukusebenzisa amayeza okwehlisa i-cholesterol. Isifo seswekile sichazwa njengokuzila ukutya kweglucose≥7.0 mmol / L kunye / okanye ukusebenzisa amayeza esifo seswekile. Usebenzisa iZiko leSizwe lezeMpilo kwi-Prostatitis Syndrome kwi-Index (NIH-CPSI), uphawu olufana ne-prostatitis (ichaphaza) luchazwa ngokuba neempawu zendlela ephantsi yomchamo (I-LUTS), kunye / kunye neentlungu kunye / okanye i-ejinali okanye [12]. Amanqaku eempawu zesifo se-Prostatic prostatic (IPSS), uvavanyo lwe-digital rectal (DRE), irekhodi yezonyango lwe-Ultra kunye nokufumana amayeza okulwa ne-androgen asetyenziselwa ukuchaza ukuchaneka kwe-benign Prostatic hyperplasia (BPH).

Bonke abasebenzi bokufunda bayigqibile ngempumelelo inkqubo yoqeqesho ebakhokelela kuzo zombini iinjongo zesifundo kunye nezixhobo ezithile kunye neendlela ezisetyenzisiweyo. Enye ityhubhu yokuzila isampulu yegazi kwathatyathwa i-serum glucose (ilinganiswa kusetyenziswa indlela ye-hexokinase enzymatic) eguquliweyo kunye nokuxilongwa kwe-lipid (kuhlalutywe enzymically kusetyenziswa ii-reagents zorhwebo ezifumanekayo) [13]. Iityhubhu ezimbini ezongeziweyo zeesampulu zegazi ezingakhawulezi zatsalwa kukutsalwa kwehomoni [14], [15], [16] kunye ne-antigen ye-antigen ethile (TPSA) epheleleyo [17], ngokulandelelana. Lonke uvavanyo lwegazi lwenziwa kwiziko leLabhoratri yezonyango (Isibhedlele iRenji, iShanghai, China).

Uhlalutyo lweSatisati

Bonke abathathi-nxaxheba bahlelwe baba ngamaqela eminyaka yobudala ngokokusasazwa kweminyaka yobudala abaphandiweyo (40-51, 52-59, 60-64, and 65-80). Isimo sesondo sahlulwahlulwa saba ngamaqela amane: i-non-ED, i-ED emdaka, ephakathi kunye ne-ED enesidima. I-ANOVA yendlela enye (idatha yahlangabezana nokuhanjiswa okuqhelekileyo), i-Kruskal-Wallis (idatha yahlangabezana nokuhanjiswa okungaqhelekanga) kunye novavanyo lwe-Chi-skwele (idatha ehleliweyo) yasetyenziswa ukuthelekisa phakathi kwamaqela amane kuzo zonke iimpawu ezinxulumene noko, kwaye ukulungiswa kweBonferroni kwasetyenziselwa ukulwa Ukhetho lokuthelekisa oluninzi. Okokugqibela, iimodeli zokuphinda ziphinde zaphononongwa ukuba ngaba iimpawu ezimiselweyo ngokubanzi, iimpawu zeklinikhi kunye neendlela zokuphila zazinxulumene nesimo sesondo. Izinto eziqhubekayo eziguquguqukayo zanikwa njengendlela mean yokuphambuka komgangatho (SD) okanye ophakathi (ubuncinci-ubuninzi). Ngokwezibalo P<0.05 yathathelwa ingqalelo njengokubonisa umahluko okhoyo phakathi kweklinikhi phakathi kwamaqela. Lonke uhlalutyo lwamanani lwenziwa kusetyenziswa i-SPSS13.0 (SPSS Inc., Chicago, Illinois, USA).

iziphumo

Kubaphenduli abafanelekileyo be-1,720, sifumene iimpendulo ezivela kwizifundo ze-1,591 (ipesenti ye-92.5) kunye neesampuli ezivavanyiweyo kwizifundo ze1,531 (ipesenti ye-89.0). Ubungakanani bempendulo zeminyaka eyahlukeneyo yokuphendula kwi-bracket yayiyi-12.9% (40-51), 22.6% (52-59), 28.0% (60-64) and 36.4% (65-80), ngokulandelelana. Ubuninzi be-ED kunye ne-asexeness status yayi-49.9% (765 / 1,531) kunye ne-37.2% (569 / 1,531), ngokulandelelana. Ukusasazeka kwesifo esinganyangekiyo kunye nenqanaba lesini phakathi kwabantwana kuyaboniswa Umzobo 1. Izizathu ezichaziweyo zesimo se-asexourse, kubandakanya ezona zizathu zibalulekileyo “azikhathalelanga ukuba neentlobano zesini” (53.5%), “ubunzima be-erectile” (52.9%), “akusafuneki ukuba neentlobano zesini okwangoku” (47.7%), "ezinzima uxinzelelo ”(44.4%) kunye ne" masturbatory erection "(26.9%), lushwankathelwe Umzobo 2.

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Umzobo 1. Ukuhanjiswa kwesifo esinganyangekiyo kunye nenqanaba lesini phakathi kwamaqela yobudala.

I-doi: 10.1371 / journal.pone.0092794.g001

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Umzobo 2. Izizathu ezizodwa zokusebenzisa ubunyani besini ngaphandle kokulalana.

I-doi: 10.1371 / journal.pone.0092794.g002

1 Table ushwankathele umahluko wezinto ezinobungozi ezinxulumene ne-ED phakathi kwamaqela amane. Ubume besimo se-asexeness babeneminyaka yobudala obudala, uxinzelelo lwegazi oluphezulu lwe-systolic, i-FBG ephezulu, i-serum creatinine kunye ne-TPSA, kunye ne-LH esezantsi; kwaye yaveza ukwanda okuphezulu kwesifo seswekile noxinzelelo lwegazi.

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Itheyibhile 1. Iimpawu ezibonakalayo kunye neeklinikhi zamadoda athatha inxaxheba ngokwamanqaku e-IIEF-5.

I-doi: 10.1371 / journal.pone.0092794.t001

2 Table ibonise unxibelelwano phakathi kwenqanaba lokwabelana ngesondo kunye nemiba yomngcipheko we-ED. Sisebenzisa ukurejista ngokwasemthethweni, safumana umanyano olungileyo phakathi komndilili ukuya kubunzima be-ED kunye nobudala obudala (umda we-odds (OK) = 8.01, 95% CI: 3.62-17.71; P<0.001), isifo seswekile (OKANYE 2.36, 95% CI: 1.16-4.80; P = 0.02), uxinzelelo lwegazi (OKANYE 1.72, 95% CI: 1.07-2.79; P = 0.03), BPH (OKANYE = 3.58, 95% CI: 1.55-8.25; P = 0.03) kunye ne-PLS (OKANYE = 5.88, 95% CI: 1.20-28.79; P = 0.03); kunye nolungelelwaniso olufanelekileyo phakathi kwesimo se-asexeness kunye nexhegu (OKANYE 18.49, 95% CI: 10.34-33.05; P<0.001), isifo seswekile (OKANYE 2.40, 95% CI: 1.36-4.25; P = 0.003) kunye noxinzelelo lwegazi (OKANYE 1.78; 95% CI: 1.25-2.55; P = 0.002).

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Itheyibhile 2. Ukudibana kunye nokuzibandakanya kwizinto ezininzi ezinefuthe lokwabelana ngesondo.

I-doi: 10.1371 / journal.pone.0092794.t002

ingxoxo

Iziphumo zethu, ezisekwe kwidatha emele ilizwe kuzwelonke eShanghai, zichaze ukuba uninzi lwabantu abadala kunye nabadala baneengxaki zesini, kwaye ngaphezulu, inani elikhulu lamadoda lazisa imeko ye-asexuality. Amadoda anesimo se-asexuality athwaxwa yimingcipheko ephezulu kunokumodareyitha kubunzima be-ED kwaye izizathu ezininzi zokuxinana kwazo zinxulunyaniswa nokudakumba kwe-erectile, ngelixa ligcuntswana lamadoda kuphela anesimo se-asexourse exela ukuba babenoluhlobo oluqhelekileyo ngexesha lokuphulula amalungu esini.

Ukuxhaphaka okuxhaphakileyo kunye nomngcipheko oqhelekileyo we-ED kwisifundo sethu ixhasa uphando lwangaphambili kumazwe ase-Asiya naseNtshona [18], [19], [20], [21]. Izinto zomngcipheko ezisekwe kwi-ED zibandakanya ukwaluphala, isifo seswekile, uxinzelelo lwegazi, i-BPH kunye ne-PLS, kwaye ukuguga kwakuyinto yomngcipheko ozimeleyo. Nangona kunjalo, sikwafumanise ukungafani kolu hlanga. Ukuxhaphaka kwe-ED kumadoda ane-40-51 iminyaka yayiyi-58.6%, ekubonakala ngathi yahlukile kwidatha kuphando oludlulileyo lwesifo (esusela kwi-2% ukuya kwi-39% emadodeni aphakathi kweminyaka ye-40 kunye ne-50 iminyaka [22]. Ukuxhaphaka okuphezulu kwe-ED kwiqela le-40-51 iminyaka kunokuthi kuchazwe ngolu hlobo: okokuqala, ubungqina obuninzi kunye nobuninzi kwiminyaka yakutshanje bubonise ukuba imeko ye-ED iyanda kakhulu kubafana abancinci nakwiminyaka ephakathi. [23], [24]; Okwesibini, umda omkhulu we-ED ethambileyo (i-53.5% kuyo yonke, engaboniswanga kwiziphumo) eboniswe kule cohort, edla ngokugqalwa kuqheliselo lweklinikhi. [25]; Okwesithathu, iimpembelelo zaseTshayina zenkcubeko kunye nezentlalo zinokubangela ukwanda kwe-psychogenic ED eboniswe kumadoda aphakathi [26], ngelixa amanqaku e-IIEF-5 engabandakanyi i-psych psych [26], [27]. Akuzange kubekho unxibelelwano lubalulekileyo phakathi kwe-ED, dyslipidemia kunye neendlela zokuphila, enokuthi yahluke kwidatha yophando e-Italiya izigulana ezine-dyslipidemia [28] okanye / kunye neendlela zokuphila ezigwenxa [29], [30] zazisemngciphekweni okhulayo wokuphuhliswa kwe-ED. Ezi ziphumo zingahambelaniyo zinokuvela ngumahluko kubemi. USmith et al. [31] ndafumanisa ukuba kwakungekho ntlangano phakathi kwenqaku elipheleleyo le-IIEF-15 okanye ubulukhuni be-ED kunye ne-serum cholesterol kunye namanqanaba e-triglyceride, kunye ne-Hall et al [32] kwafumanisa ukuba akukho manyano ubalulekileyo phakathi kokungafunyanwa kwe-hyperlipidemia kunye ne-ED kwimodeli ye-multivariate. Kubantu bethu abafundayo, uninzi lwezifundo lwaluneminyaka yobudala (iipesenti ezingama-64.5> iminyaka engama-60) kwaye luye lwasokola ngokwanda kwezifo, ngenxa yoko imeko yabo yezempilo ibabongoza ukuba baphucule indlela yabo yokuphila (umzekelo, ukuphuculwa kokutya kunye nokuziphatha komzimba), ethi Unokufumana inzuzo kulawulo lwedyslipidemia kunye nokukhuluphala. Kodwa kwelinye icala, ezi zinto zifunyanisiweyo zicebise ukuba i-ED kweli cohort inokuchaphazeleka ngakumbi zizifo zenkqubo kunokuba zibekho kwindlela yokuphila eyahlukileyo.

Inkqubo yokufumana amanqaku i-IIEF (okanye IIEF-5) isetyenziswa ngokubanzi ukuvavanya ukusebenza kwe-erectile [33], [34]. Nangona kunjalo, iphepha lemibuzo, ukungathathi i-akhawunti yamadoda "engenzi zinto zesini kwiiveki ze-4 zokugqibela", lilinganiselwe ekuhloleni imeko ye-asexourse echazwe apha njengengabinayo imizamo yesini ngaphezulu kweenyanga ze-6. Njengoko kungekho zindululo zichaziweyo zokuvavanya ubunyani kwizikhokelo zeklinikhi, izifundo ezinesimo sempilo esexesheni zihlala zikhutshelwa ngaphandle kubuninzi bezifundo kwiingxelo ezininzi. Nangona kunjalo, impendulo yalo mbuzo ibaluleke ngokukodwa njengoko kukho inani elikhulu labantu abanobuncinci be-asexual yethutyana, ngokukodwa abantu abadala [35], [36]. Kwisifundo sethu, i-37.2% yamadoda aphakathi kunye namadoda amadala aveze imeko ye-asexility, ngaloo ndlela ebonisa ukuba uhlalutyo lweli qelana aliyikhathalelwa. Ukwenzela ukucacisa imeko ethandabuzekayo yomsebenzi we-erectile (ugqityiwe u-ED okanye umsebenzi oqhelekileyo we-erectile) cohort ngesimo se-asexourse, sithelekise imeko ye-asexeness kunye ne-moderate ukuya kwi-ED enzima kunye ne-non-ED ngokwemeko yomngcipheko ehambelana ne-ED. Umngcipheko weengozi ezihlengahlengisiweyo zeminyaka ye-60-64 iminyaka kunye ne-65-80 iminyaka ekuphenduleni ngesimo se-asexourse yayiphezulu kakhulu kunakwi-cohort ene-moderate ukuya kwi-ED enzima nge-2.5 fold kunye ne-2.2 fold, ngokulandelanayo. Ngaphaya koko, umngcipheko weswekile kunye noxinzelelo lwempembelelo kumadoda ane-asexuality level ayephezulu kunolingano kumadoda angama-ED aqatha. Ezi ziphumo zicebise ukuba uninzi lweemeko ezinesimo sokusebenza kwe-exxeness zinokuba zinxulumene ne-ED epheleleyo, iyaqondakalayo kuba uninzi lwamadoda anesimo sokungatshati aphulukene nobuchule bokwabelana ngesondo okuqhelekileyo.

Kwiinzame zokuqinisekisa ukutheleleka okuthethwe ngaphambili, siqokelele izizathu zethu zokunikwa kwengxelo yokuba ngubani umntu ongatshatanga naye ngokwesondo. Ulwazi oluzimeleyo kwingxelo yethu lubonise ukuba i-52.9% yamadoda akwinqanaba lesimo se-asexourse athatha "ubunzima be-erectile" njengesona sizathu siphambili sesexualization, exhasa ukungqinisisa okukhankanywe ngaphambili. Ngaphaya koko, izikhalazo zoxinzelelo olukhulu "(44.4%)," ukudinwa okukhulu "(26.3%)," ubudlelwane obuphathelele kwezesondo "(4.4%) kunye" nolwaneliseko lobomi obuphantsi "(3.0%), ezimele intlalontle, eyengqondo kunye neyomzimba Uxinzelelo olubangela ifuthe elibi kwimicimbi yezesondo kunye nokwakhiwa [37], [38], yayizizizathu zokuphuhliswa kokusebenza kobuhlanga kuluntu. Ezi zinto zifunyanisiweyo zichaze inxenye yokuba kutheni uninzi lwamadoda ane-asexourse enengxaki yokufumana ubunzima kwi-erectile. Siqaphele ukuba uninzi lwamadoda ane-asexual status ethathwa njenge "ayikhathaleli ngesondo" (53.5%) kwaye "akusafuneki ukuba neentlobano zesini ngeli xesha" (47.7%) njengesinye sezizathu ezibini zokubaxekileyo, kwaye kubonakala ngathi amadoda ukubonelela ngezi zizathu kunokuba nomsebenzi oqhelekileyo we-erectile. Ngapha koko, le nto yabandakanya iinkalo ezimbini: isimo sengqondo malunga nokulalana kunye nokuswela umdla. Njengokuba uninzi lwamadoda anenqanaba le-asexual ebetshatile okanye enobomi obuphathekayo obuphathelele kwezesondo, imeko ye-exxual apha yahlukile kwimeko engagungqiyo yesondo engavumiyo ukuba neentlobano zesini kunye nokungatshati kubangelwe zizinkolelo zomntu okanye ezenkolo okanye [39]. Ngenxa yoko esona sizathu sokuba omehluko wesimo sengqondo sokulalana sisenokuba yinkxalabo yokuba izinto ezenziwa ngesondo zingayenza ingozi kwimpilo yabo ekhula ngokukhula. Ukunqongophala komdla wesini kungahambelana nobudala obudala (kuthetha ukuba i-65.70 ± iminyaka ye-8.20), i-testosterone esezantsi esezantsi (ngokuthelekiswa ne-non-ED) kunye nokuhamba nezifo ezinganyangekiyo, ezihambelana nedatha kwi-European Male ukuguga Kwisifundo (EMAS) [40]. Ukuhla kwenqanaba le-testosterone ye-serum kuya kukhokelela ekulahlekeni kancinci kwe-libido [41], kunye nokusilela kwe-serum testosterone inokubangela ukungasebenzi kakuhle kwe-erectile ngokuchaphazela i-vasodilation ye-penile arterioles kunye ne-cavernous sinusoids [42]. Yiyo loo nto ke iinkolelo zesondo ezahlukileyo kunye nomnqweno wesini ophantsi unxulumene nemiba yomngcipheko ye-ED nayo.

Amadoda anenqanaba elinye kunye namava okuphulula amalungu esini anokucebisa ukuba bagcina umsebenzi oqhelekileyo we-erectile nokuba babengenazame zokwabelana ngesondo. Nangona kunjalo, sifumanise ukuba inani elincinci lamadoda anenqanaba elisemthethweni athatyathwa njeng "atshatanga, umhlolokazi, oqhawule umtshato okanye ahlukanisiweyo "(i-4.3%) njengezizathu zokusebenzisa ubunyani besifundo. Nangona bejikeleze ikota yamadoda ane-asexeness echaziweyo ukuba anamava ngokuphulula amalungu esini, kuphela i-35.3% yabo (i-9.5% kubo bonke) ithathele ingqalelo ukuba banokulinganiswa okuqhelekileyo kokupenda. Ngamafutshane, nangona kuchazwe izizathu ezahlukeneyo zokuxinana, uninzi lwazo zinokubangelwa bubunzima be-erectile kunye nemingcipheko yayo.

Olu phononongo lunamandla aliqela, kubandakanya noyilo olusekelwe kubemi bokufunda, ubungakanani besampulu enkulu ngokubanzi kunye neeprothokholi ezimiselweyo eziqhutywa ngabavavanyi abaqeqeshiweyo. Ukukhethwa kokukhetha kuncitshiswe ngenxa yamanani aphakamileyo okuphendula ngokugaya (i-92.5%). Ngokubalulekileyo, sichaza imeko ye-asexities ngokuchanekileyo kunye nokuhlelwa kwezifundo kunye ne-asexeness njengesiqwengana sohlalutyo. Ukuphononongwa kwemeko ye-asexuality status vis-a-vis yobomi obuhlala buhleli kunokongeza kuluncwadi njengoko kungekho ngcebiso ithile yokuvavanya ukusebenza kwe-sexual ikhona kwimo yezonyango. Nangona kunjalo, ukusikelwa umda kolu phando kufuneka kuthathelwe ingqalelo xa kutolikwa iziphumo. Njengophando oluninzi olufanayo, enye inkxalabo kukuba ezinye idatha zazichazwa, nangona iindlela zodliwano ndlebe zamkelwe njengezisemthethweni. Ukujongana nale nkxalabo, siqokelele idatha yeenjongo njengoko kunokwenzeka ukuxhasa iziphumo zokuzixela. Okunye okuxhalabisayo kukuba asizange siqokelele ulwazi oluchanekileyo malunga nemeko esempilweni yamaqabane amabhinqa kwaye asikhange siphonononge kwaye sihlalutye imeko yobomi be-exesual eyahlukileyo kwimeko yethuba lokuxakeka kubemi bethu.

Ukuqukumbela, imeko ye-asexuality yayihlala iphakathi kwabadala abaphakathi ukuya kumadoda amadala, kwaye amadoda anale meko ahlangabezana nemingcipheko ephezulu ye-ED kunamadoda anokumodareyitha ngokuqatha. Uninzi lwesimo se-asexuality sinokuchatshazelwa yimeko ye-ED epheleleyo, nangona izizathu zesimo se-asexourse sikwabandakanya izimo zengqondo zesini kunye nezinto onomdla kuzo, amaqabane ezesondo kunye nokuziphulula amalungu esini. Izifundo ezongezelelweyo ziyafuneka ukuyila uphando olululo lokuvavanya ubukho bemeko esebenzayo ye-organic kunye ne-psychogenic erectile ebantwini abanesimo sezinto zokuphila, kwaye zichonge necandelwana lamadoda asisigxina asisigxina, kubandakanya amadoda amancinci kakhulu, okt, ukuya kutsho kwiminyaka ye-18. Okokugqibela kuya kunceda ukuchaza ezona zinto, ukuza kuthi ga ngoku zingaziwa, ezinokuthi zenze ukuba abafana bangathandeki kubomi besondo obusebenzayo.

Imibulelo

Ababhali bangathanda ukubulela uNjingalwazi Cadavid Nestor Gonzalez-Cadavid (iSebe leUurology, iCLA School of Medicine, uCharles Drew University) ngoncedo lwalo mbhalo.

Umbhali Wemivuzo

Yamkela kwaye yacwangcisa uvavanyo: BC YW YH. Wenza uvavanyo: PP HW KH HY TF YJ TZ YH. Uhlalutyo lwedatha: YH HW KH HY TF YJ TZ. I-reagents enegalelo / izixhobo / izixhobo zokuhlalutya: KH HY TF YJ TZ. Bhala iphepha: YH HW. Ukuyihlaziya kwakhona ngomxholo weNgcali: uBin Chen Ping Ping Hong-Xiang Wang Kai Hu Hao Yang Tan Feng Yan Jin Tao Zhang.

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