Neuroimage. 2015 Aug 7. pii: S1053-8119 (15) 00709-0. i-Doi: 10.1016 / j.neuroimage.2015.08.001. [Epub phambili kwishicilelo]
UTuominen L1, UTuulari J2, IKarlsson H2, UHirvonen J2, Helin S2, Isalmin P3, IParkkola R4, UHietala J5, I-Nuutila P2, Nummenmaa L6.
Abstract
Iinkqubo ze-dopamine kunye ne-opioid neurotransmitter zabelana ngemisebenzi emininzi enje ngommiselo womvuzo nolonwabo. Ii-receptors ze-μ-Opioid (MOR) ziguqula inkqubo ye-mesolimbic dopamine kwindawo yecandelo lokugqobhoza kunye ne-striatum, iindawo eziphambili ezibekiweyo kumvuzo. Sifumene ubungqina bokuba i-dopamine kunye ne-opioid receptor ekhoyo ilungelelanisa kwi-vivo kwaye oku kulungelelwaniso kuguqulwa kukukhuluphala, sisifo esiguquliweyo somvuzo.
Amashumi amabini amanenekazi amanenekazi (kuthetha ukuba i-BMI 22) kunye ne-25 engadli ngokutya okungaswelekiyo kwabasetyhini ababhinqileyo (kuthetha ukuba i-BMI 41) ihamba iskena esine-positron emission tomography11C] i-carfentanil kunye [11C] i-raclopride yokulinganisa i-MOR kunye ne-dopamine D2 receptor (DRD2), ngokulandelanayo.
Kwizifundo ezinqabileyo, ukufumaneka kwe-MOR kunye ne-DRD2 kwakudibene ngokuqinisekileyo kwi-ventral striatum (r = 0.62, p = 0.003) kunye dorsal caudate nucleus (r = 0.62, p = 0.004). Ngaphaya koko, ukubakho kwe-DRD2 kwisimo se-ventral kwayanyaniswa nokufumaneka kwe-MOR kweminye imimandla yomjikelezo womvuzo, ngakumbi kwindawo yecandelo le-venral.
IIzifundo ezi-ethe-ethe ngokuziphatha, oku kudibana kwe-receptor kwakubuthathaka kakhulu kwi-ventral striatum kodwa kungafakwanga kwi-caudate nucleus.
Okokugqibela, unxibelelwano phakathi kokufumaneka kwe-DRD2 kwindawo ye-ventral striatum kunye nokufumaneka kwe-MOR kwindawo yecandelo le-ventral yatshitshiswa kwi-obese e-morbidly.
Isifundo sibonisa ikhonkco phakathi kwe-DRD2 kunye nokufumaneka kwe-MOR kwingqondo yomntu ephilayo. Olu nxibelelwano luchaphazeleka ngokukhethekileyo kwinkqubo ye-mesolimbic dopamine kwi-morbid obesityala. Sicebisa ukuba ukusebenzisana phakathi kweedopamine kunye neenkqubo ze-opioid kuyimfuneko yokuqhubekiswa kwembuyekezo eqhelekileyo kwaye ukuphazamiseka kwentetho-yomgaqo kunokuguqula ukuguqulwa komvuzo kwi-obesity.
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