izimvo: Uphononongo lufumene i-dopamine esezantsi kakhulu i-receptors ye-D2 kubantu abatyebe kakhulu, kwaye okukhona batyebe kakhulu, kokukhona ukuncitshiswa kwe-D2 receptors.
Lancet. 2001 Feb 3;357(9253):354-7.
Wang GJ, Volkow ND, Logan J, UPapas NR, Wong CT, UZhu W, Netusil N, UFowler JS.
imvelaphi
ISebe lezoNyango, i-Brookhaven National Laboratory, e-Upton, eNew York 11973, eU.SA. [imeyile ikhuselwe]
Abstract
UMGQUBO:
Iinkqubo ze-cerebral eziphantsi kokuziphatha okukhokelela kwi-pathological overeating kunye nokukhuluphala akuqondwa kakuhle. I-Dopamine, i-neurotransmitter emodareyitha iipropathi ezinomvuzo wokutya, kusenokwenzeka ukuba ibandakanyeke. Ukuvavanya i-hypothesis yokuba abantu abatyebe ngokugqithiseleyo banokungaqhelekanga kumsebenzi we-dopamine yobuchopho silinganise ukufumaneka kwe-dopamine D2 receptors ebuchosheni.
IINDLELA:
Ubukho be-Brain dopamine D2 receptor yalinganiswa nge-positron emission tomography (PET) kunye ne- [C-11] raclopride (i-radioligand ye-dopamine D2 receptor). I-Bmax/Kd (umlinganiselo wemithamo yokuhanjiswa kwi-striatum ukuya kuleyo ikwi-cerebellum minus 1) yasetyenziswa njengomlinganiselo wokufumaneka kwe-dopamine D2 receptor. Imetabolism yeglucose yobuchopho nayo yavavanywa nge-2-deoxy-2[18F]fluoro-D-glucose (FDG).
IINDLELA:
Ukufumaneka kwe-striatal dopamine D2 receptor bekusezantsi kakhulu kubantu abalishumi abatyebe kakhulu (2.47 [SD 0.36]) kunolawulo (2.99 [0.41]; p <okanye = 0.0075). Kubantu abatyebe ngokugqithiseleyo, i-body mass index (BMI) ihambelana kakubi kunye nemilinganiselo ye-D2 receptors (r=0.84; p <okanye = 0.002); abantu abanawona maxabiso asezantsi eD2 baneyona BM inkuluI. Ngokwahlukileyo, akukho ngqondo iphela okanye i-metabolism yokuzala yahluke phakathi kwabantu abatyebe kakhulu kunye nolawulo, nto leyo ebonisa ukuba ukuncitshiswa kokubulawa kwabantu kwi-D2 receptors akubanga ngenxa yokuncipha okucwangcisiweyo kokuhanjiswa kwe-radiotracer.
UTSHINTSHO:
Ubukho be-dopamine D2 receptor yehlisiwe kubantu abatyebe kakhulu ngokomlinganiselo we-BMI yabo. I-Dopamine imodareyitha inkuthazo kunye neesekethe zomvuzo kwaye ngenxa yoko ukunqongophala kwe-dopamine kubantu abatyebe kakhulu kunokuqhubela phambili ukutya kwe-pathological njengendlela yokubuyisela ukusebenza okucuthiweyo kwezi sekethe. Amaqhinga ajolise ekuphuculeni ukusebenza kwe-dopamine kunokuba luncedo kunyango lwabantu abatyebe kakhulu.
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