NgoSeptemba 20, 2012 kuphando lwezoNyango
Amanqanaba e-enkephalin e-Extracellular enyuka xa iimpuku ziqala ukutya itshokolethi yobisi M&Ms. Ukuqala kokutya kuhambelana nokunyuka okunamandla kwe-extracellular enkephalin (i-met kunye ne-leu), ehlala izinzileyo ngexesha lokutya kwaye ngokuthe ngcembe iyancipha njengoko ukutya kuncipha. Ubungakanani bokunyuka kwe-enkephalin kubantu abahambelana ne-latency yabo yokutya i-M & M yabo yokuqala: ukunyuka kwe-enkephalin ephezulu kubadla ngokukhawuleza.
Ityala: Current Biology, DOI: 10.1016/j.cub. 2012.08.014
"Oku kuthetha ukuba ingqondo ineenkqubo ezibanzi zokwenza abantu bafune ukusebenzisa imivuzo ngokugqithisileyo kunokuba bekucingelwa ngaphambili," utshilo u-Alexandra DiFeliceantonio weYunivesithi yaseMichigan, uAnn Arbor. “Isenokuba sesinye sezizathu zokuba ukusetyenziswa ngokugqithiseleyo kuyingxaki namhlanje.”
Iqela likaDiFeliceantonio lifumanise ngokunika iimpuku ukomeleza okwenziweyo ngechiza eliziswe ngqo kwindawo yobuchopho ebizwa ngokuba yi-neostriatum. Ezo zilwanyana zazonwabisa ngaphezu kwenani eliphindwe kabini leetshokolethi zeM&M kunokuba bezinokutya. Abaphandi bafumanisa ukuba i-enkephalin, ikhemikhali yendalo efana neziyobisi eveliswe kuloo mmandla wobuchopho, yanda xa iigundane zaqala ukutya i-candy-coated morsels, nazo.
Akunjalo ukuba i-enkephalins okanye iziyobisi ezifanayo zenza iigundane zithande iitshokholethi ngakumbi, abaphandi bathi, kodwa kunokuba iikhemikhali zengqondo zandisa umnqweno wazo kunye nomnqweno wokuzidla.
Iziphumo zityhila ukongezwa okumangalisayo kwendima ye-neostriatum, njengoko uDiFeliceantonio ephawula ukuba ummandla wobuchopho wawudityaniswe ngokuyintloko nentshukumo. Kwaye kukho isizathu sokulindela ukuba okufunyaniswe kwiimpuku kunokusixelela okuninzi malunga notyekelo lwethu lokutya kakhulu.
Uthi: “Kwale ndawo yobuchopho siyivavanye apha iyasebenza xa abantu abatyebe ngokugqithiseleyo bebona ukutya naxa amakhoboka eziyobisi ebona iziyobisi,” utshilo. "Kubonakala ngathi iziphumo zethu ze-enkephalin kwiigundane zithetha ukuba le neurotransmitter inokuqhuba ezinye iindlela zokusebenzisa ngokugqithiseleyo kunye nokulutha ebantwini."
Abaphandi ngoku banethemba lokutyhila into enxulumene noko abanye bethu banokunqwenela ukuba sinokwenza okungakumbi ukulawula: kwenzeka ntoni kwiingqondo zethu xa sidlula kwindawo yethu yokutyela yokutya okukhawulezayo kwaye siziva ukuba umnqweno wokuyeka ngequbuliso.
Olunye ulwazi: DiFeliceantonio et al.: "I-Enkephalin inyuka kwi-dorsal neostriatum njengomqondiso wokutya." I-DOI: 10.1016/j.cub.2012.08.014
"Uphononongo lwengqondo lutyhila iingcambu zezilingo zetshokholethi." NgoSeptemba 20, 2012. http://medicalxpress.com/news/2012-09-brain-reveals-roots-chocolate-temptations.html
I-Enkephalin igxuma kwi-dorsal neostriatum njengomqondiso wokutya.
Ibhayoloji yangoku, 20 Septemba 2012
Ilungelo lokushicilela © 2012 Elsevier Ltd Onke amalungelo agciniwe.
10.1016 / j.cub.2012.08.014
Authors
- Ukunyuka kwe-Enkephalin kwi-neostriatum kubangelwa ukutya imivuzo emnandi
- Ukutya okugqithisileyo kuveliswa ngokukodwa yinxalenye ye-anteromedial ye-dorsal neostriatum
- I-Neostriatum opioid stimulation ibangela ukutya okuninzi kodwa hayi "ukuthanda" ubumnandi
isishwankathelo
Ukusetyenziswa ngokugqithisileyo komvuzo ngokugqithisileyo kubonisa ukuphazamiseka okususela ekutyeni kakhulu ukuya ekubeni likhoboka leziyobisi. Apha, sinika ubungqina bokuba i-enkephalin inyuka kwi-quadrant ye-anteromedial ye-dorsal neostriatum inegalelo ekuveliseni ukusetyenziswa okunamandla kokutya okunencasa. Kwi-ventral striatum, i-opioid circuitry inegalelo elibalulekileyo lenkuthazo yokutya umvuzo [1,2,3,4]. Kwi-dorsal neostriatum, ii-receptors ze-opioid zigxininiswe ngaphakathi kwe-striosomes ezifumana amagalelo avela kwimimandla ye-limbic ye-prefrontal cortex [5,6,7,8,9,10,11,12,13]. Sisebenzise iindlela eziphambili ze-opioid microdialysis ezivumela ukubonwa kwamanqanaba e-extracellular enkephalin. Endogenous >150% enkephalin surges in anterior dorsomedial neostriatum yaqalwa njengoko iimpuku zaqala ukutya iitshokolethi ezinencasa. Ngokwahlukileyo, amanqanaba e-dynorphin ahlala engatshintshi. Ngapha koko, indima ye-causal yokuvuselela i-opioid ekusetyenzisweni ngokugqithiseleyo kwaboniswa ngokuqwalasela ukuba i-microinjection kwi-anterior dorsomedial quadrant ye-mu receptor agonist ([D-Ala2, N-MePhe4, Gly-ol]-enkephalin; i-DAMGO) yenziwe kakhulu. I-250% yonyuka ekuthathweni kokutya okumnandi okunencasa (ngaphandle kokutshintsha impembelelo ye-hedonic yeencasa ezimnandi). Ukwenza imephu ngeendlela ze-“Fos plume” eziqinisekisiweyoIsiphumo se-hyperphagic kufuneka sibekwe kwindawo ye-anteromedial quadrant ye-dorsal neostriatum, ngelixa ezinye ii-quadrants bezingasebenzi kakuhle.. Ezi ziphumo zityhila ukuba imiqondiso ye-opioid kwi-anteromedial dorsal neostriatum iyakwazi ukwenza ikhowudi kwaye ibangele inkuthazo yokutya umvuzo weemvakalelo.
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