Physiol Behav. I-2012 Jun 6; 106 (3): 332-6. doi: 10.1016 / j.physbeh.2012.03.020.
imvelaphi
IYunivesithi yaseFlorida, ikholeji yezonyango, iSebe lezeengqondo, McK Night Brain Institute, Gainesville FL 32610, United States. [imeyile ikhuselwe]
Abstract
Nangona zenza nje isahlulo esincinci se-neurons kwingingqi, i-cholinergic interneurons kwi-dorsal striatum ibonakala ngathi idlala indima ebalulekileyo kulawulo lweendlela ezahlukeneyo zokutya, ngokuyinxalenye, ngokusebenzisana kwabo neesistimimbic dopamine (DA) iinkqubo. Kolu hlaziyo, sichaza izifundo ezibonisa ukuba imisebenzi ye-cholinergic interneurons kwi-nucleus accumbens (NAc) kunye noqikelelo lwe-cholinergic kwindawo ye-ventral tegmental (VTA) ichaphazela indlela yokutya.
Kwizifundo ze-vivo microdialysis kwiigundane ziye ityhila ukuba ukuyeka isidlo kunxulunyaniswa nokunyuka kwamanqanaba e-acetylcholine (ACh) kwi-NAc. Ukusebenza kwe-ACh kuya kucinezela ukondla, kwaye oku kuyadityaniswa nokunyuka kokuqokelelwa kwe-ACh. Ngaphaya koko, sixoxa ngendlela, ukongeza kwindima yabo ekuphelisweni kwesidlo, ii-interinurons ze-cholinergic kwi-NAc zidlala indima ebalulekileyo ekuphelisweni kokusetyenziswa kweziyobisi. Enye inkqubo ye-cholinergic ebandakanyekayo kwiinkalo ezahlukeneyo zokuziphatha kukunganikezeli kuqikelelo olusuka kwi-pedunculpontine nuclei ngqo kwi-VTA. Ukusebenza kwale nkqubo kuphucula indlela yokuziphatha ngokusebenza kwenkqubo ye-mesolimbic DA, kunye I-antagonism of ACh receptors kwi-VTA inokunciphisa ukuzilawula kwezamachiza. Okokugqibela, sixoxa ngendima yokuqokelelwa kwe-ACh kokubini ukurhoxisa iziyobisi kunye nokutya okuthandekayo.
Izifundo zityhila ukuba i-accumbens ACh iyanda ngexesha lokurhoxa kumachiza ohlukeneyo okuphathwa gadalala (kubandakanya icocaine, nicotine kunye ne morphine). Oku kunyuka kwamanqanaba angaphezulu kweeseli ze-ACh, kudityaniswa nokwehla kwamanqanaba angaphandle kwe-DA, kukholelwa ukuba kuya kuba negalelo kwimeko ephikisayo, enokubonakalisa njengeendlela zokuziphatha ezinxulumene nokurhoxiswa kweziyobisi. Le ithiyori ikwasetyenzisiwe kwizifundo zokutya kakhulu kunye / okanye "umlutha wokutya," kwaye iziphumo zibonisa ukungalingani okufanayo kumanqanaba e-DA / ACh, enxulunyaniswa neendlela zokuziphatha zokurhoxa okufana neziyobisi.
Isishwankathelo, ii-neuron ze-cholinergic zidlala indima ebalulekileyo kwimodyuli yokutya kunye nokutya iziyobisi, kunye neenkalo zokutya kunye nokuziphatha okuhambelana neziyobisi.
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