Neuropsychiatr Dis Treat. I-2019 ngoMeyi 8; 15: 1211-1229. i-Doi: 10.2147 / NDT.S204818.
Wei NL1,2, QAPHELA ZF3,4, UZhao T.1, Yu XD4, Xie Q1, UZeng J1, UMa FK1, Wang F1, I-Tang QS1, Wu H3, UZhu JH1.
Abstract
imvelaphi: Ukudakumba okunxulumene noxinzelelo kunokuba kunxulumene noxinzelelo lwe-axothalamic-pituitary- adrenocortical axis kunye ne-dysregulation ye-metabolic system. Uxinzelelo olungapheliyo lukwabangela ukudodobala kwenkqubo yembuyekezo kwaye yandise umngcipheko wokufumana iziyobisi ngokutya, ngokokufumanisa kwekliniki kutshanje. Nangona kunjalo, zimbalwa izifundo ezivavanye isiphumo soxinzelelo olungapheliyo kwisifo sokutya kwiimodeli zezilwanyana.
Injongo: Injongo yolu phononongo yayikukuchonga ukuba ingaba uxinzelelo olungapheliyo lukhuthaza ukulutha kokutya okanye hayi kunye nokuphonononga iindlela ezinokubakho.
Indlela: Sisebenzise yonke imihla i-2 hrs edanyaza ngoxinzelelo lwe-irradiation ye-LED kwiigundane ezityiweyo okanye ukutya okuthandekayo ukulingisa isiphumo soxinzelelo olungapheliyo ekutyeni. Emva kwenyanga ye-1 yokuvezwa koxinzelelo, siye savavanya indlela abanengxaki yokutya ngayo, iinkanuko zokutya okuqinisekileyo, iimpendulo zokutya okuthandekayo, kunye nokuziphatha okunyanzelekileyo kokutya ukuvavanya ifuthe loxinzelelo lokuziphatha okungaqhelekanga. Sifumene utshintsho kumanqanaba eentlobo ezahlukeneyo zofuzo kunye neeproteni kwi-nucleus accumbens (NAc), indawo ye-ventral tegmental (VTA) kunye ne-hypothalamus yecalft esebenzisa i-qPCR kunye ne-immunofluorescence stain, ngokulandelanayo.
iziphumo: Iziphumo ze-Behaviors zibonise ukuba uxinzelelo olungapheliyo ngokuqinisekileyo lonyusa inqaku lokutya (FAS) kwimigudu yokutya yokutya. Ngapha koko, i-FAS yayinobudlelwane obuluqilima kunye nobungakanani bokunyuka komzimba. Uxinzelelo olungapheliyo lwonyusa ukubonakaliswa kwe-corticotropin-releasing factor receptor 1 (CRFR1) yonyuswe kwiqokobhe le-NAc kunye nesiseko kodwa yancipha kwi-VTA yeempuku ezondliwe ngokutya okuthandekayo. Uxinzelelo olungapheliyo kunye nokunyusa ukubonakaliswa kokubini kwe-dopamine receptor 2 (DR2) kunye ne-mu-opioid receptor (MOR) kwi-NAc.
Isiphelo: Uxinzelelo olungapheliyo luyenza mandundu i-FAS kwaye inegalelo kuphuhliso lokutyeba okunxulumene noxinzelelo. Uxinzelelo olungapheliyo luqhuba u-dysregulation wendlela ye-CRF isayinela kwinkqubo yomvuzo kwaye inyusa ukubonakaliswa kwe-DR2 kunye neMOR kwi-nucleus accumbens.
IINKCUKACHA: uxinzelelo olungapheliyo; dopamine receptor 2; iziyobisi i-mu-opioid receptor; i-nucleus accumbens; ukutyeba kakhulu
PMID: 31190828
PMCID: PMC6512647
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