Behav Neurosci. 2017 Apr;131(2):155-167. doi: 10.1037/bne0000185.
ICampbell EJ1, UBarker DJ2, Nasser HM3, UKaganovsky K4, Emini CV1, Ngomhla wamantla eNW4.
Abstract
Ebantwini, ukubuyela kwindlela yokutya engalunganga emva kokutya kukuthintela kakhulu kunyango lokukhuluphala. Iimpawu ezinxulumene nokutya zezona zinto ziphambili zokuphinda ubuye kukutya okungenampilo ngexesha lokuzinqanda ngokwakho. Apha sinika ingxelo yendlela yokuziphatha evavanya ukubuyela kwakhona kwe-cue-ekondleni kokutya okulandela ukohlwaya okuphembelela ukuthathwa kokutya. Siqeqeshe iigundane ezingamadoda ukuhambisa umatshini wokushicilela kwiifandesi zokutya eziswa emva kovuselelo olunemibandela ye10-CS (iphimbo). Ukulandela uqeqesho, i-25% yomatshini wokushicilela we-lever oqinisiweyo wabangela ukuvezwa kwenkuthazo equka inoveli ye-CS (i-aversive) kunye ne-CS yokutya elandelwa yi-pellet kunye ne-footshock. Emva kokuyahlwaywa okusosezweni, siye savavanya iigundane kuvavanyo lokupheliswa apho ukucinezelwa kwe-lever kwakhokelela ekunikezelweni kwe-appetitive okanye ye-CS ephikisayo. Sithe ke sithelekisa umsebenzi we-lateral hypothalamus (LH) kunye nemimandla engqamene ne-extrahypothalamic elandela olu vavanyo. Siphonononge uvavanyo lweFos kwi-LH orexin kunye ne-GABA neurons. Sifumanise ukuba ukuphinda-phinda okubangelwa kukubuyela kwakhona kokutya kufuna uvavanyo kwakuphezulu kumagundane kuvavanywa nge-CS engathandabuzekiyo. Ukubuyela umva okuboniswe ngumnqweno wokutya we-CS kwakudityaniswa ne-Fos expression e-LH, i-caudal basolateral amygdala (BLA), kunye ne-medial amygdala (MeA). Ukuphinda ubuye kwakhona kwakudityaniswa nokunyusa ukubonakaliswa kweFos kwi-LH orexin kunye ne-neurons eveza i-VGAT. Ezi datha zibonisa ukuba ukuphinda ubuye ekufuneni ukutya kungabangelwa kukutya okuhambelana nokutya emva kokuyeka ukohlwaywa, kwaye oku kuphinda kudityaniswe nomsebenzi owandisiweyo kwi-LH, kwi-caudal BLA, nakwi-MeA. (Ingxelo egciniweyo yedatha ye-PsycINFO
PMID: 28221079
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