IHippocampus. 2015 Feb;25(2):227-39. doi: 10.1002/hipo.22368.
Hsu TM1, Konanur VR, Uthetha L, Usuyi R, Kayser BD, Goran MI, Kanoski SE.
Abstract
Ukusetyenziswa kakhulu kweeswekile ezongeziweyo kuchaphazela kakubi inkqubo ye-metabolic; nangona kunjalo, iziphumo ekusebenzeni kwengqondo aziqondwa kakuhle. Kwakhona ayaziwa ukuba ngaba iziphumo ezingalunganga ezinxulumene nokusetyenziswa kweswekile ezahlukeneyo zigqithiswa ngexesha elibalulekileyo lophuhliso (umzekelo, ukufikisa). Apha sihlolisise iziphumo ze-sucrose kunye ne-fructose ephezulu ye-corn syrup-55 (HFCS-55) yokutya ngexesha lokufikisa okanye ekubeni ngumntu omdala kwiziphumo zengqondo kunye ne-metabolic. Iigundane ezifikisayo okanye eziyindoda ezikhulileyo zanikwa ukufikelela kweentsuku ze-30 kwi-chow, amanzi, kunye nokuba (1) 11% isisombululo se-sucrose, (2) isisombululo se-11% se-HFCS-55, okanye (3) ibhotile eyongezelelweyo yamanzi (ukulawula). Kwiimpuku ezifikisayo, i-HFCS-55 ithatha indawo yokufunda exhomekeke kwi-hippocampal kunye nememori kwindawo ye-Barne's maze, kunye nokuphazamiseka kokufunda okuphakathi kuqwalaselwe iqela le-sucrose. Ukuphazamiseka kokufunda kunye nenkumbulo akunakufane kwenzeke ngokusekwe kwiziphumo ezingezizo zokuziphatha njengoko ukusetyenziswa kwe-HFCS-55 ekwishumi elivisayo akuzange kuchaphazele ukuxhalaba kwimaze enguziro okanye intsebenzo kumsebenzi wokufunda impendulo engeyiyo indawo kusetyenziswa isivuseleli esifanayo esithomalalisayo njengemaze yeBarne. Ukubonakaliswa kweprotheyini ye-pro-inflammatory cytokines (i-interleukin 6, i-interleukin 1β) yonyuswa kwi-dorsal hippocampus kwiqela le-HFCS-55 elifikisayo elinxulumene nolawulo olungenayo impembelelo ebalulekileyo kwiqela le-sucrose, kanti i-interleukin ye-1β yesibindi kunye ne-plasma ye-insulin amanqanaba aphakanyisiweyo. omabini amaqela eswekile eselula. Ngokwahlukileyo, ukuthathwa kwe-HFCS-55 okanye i-sucrose kubantu abadala ayizange ibe nefuthe ekufundeni kwendawo, ukunyamezela kwe-glucose, ukuxhalaba, okanye iimpawu ze-neuroinflammatory. Ezi datha zibonisa ukuba ukusetyenziswa kweswekile eyongeziweyo, ngakumbi i-HFCS-55, ichaphazela kakubi umsebenzi we-hippocampal, iziphumo ze-metabolic, kunye ne-neuroinflammation xa isetyenziswe ngokugqithisileyo ngexesha lokufikisa.
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