Neurobiol Dis. 2016 Feb 25. pii: S0969-9961(16)30042-0. doi: 10.1016/j.nbd.2016.02.021.
Iitoti EG1, Taylor JR2, IGourley SL3.
Abstract
Into ebangwa yi-neurotrophic factor (BDNF) ichaphazela ukuqina kwe-synaptic kunye nesakhiwo se-neural kwaye idlala iindima eziphambili ekufundeni nakwiinkqubo zememori. Ubungqina bamva nje bukwabonisa ukubaluleka, kodwa okuntsonkothileyo, iindima ze-BDNF kwimodeli yokuxhatshazwa kwecocaine kunye neziyobisi. Apha sivavanya indima yokudalwa kwesigqibo sokuqala (i-PFC) se-BDNF kwisigqibo esimalunga nomvuzo kunye nokuziva uziva ngokuziphatha, kunye nokuphendula i-cocaine. Sigxile kwi-BDNF ngaphakathi kwe-PFC yodidi kunye ne-orbital, umgaqo wayo yi-cocaine ngexesha lophuhliso lwasemva kokubeleka kunye nokuba mdala, kunye nendlela iBDNF ekuphenduleni ngayo ekuqiniseni iziyobisi, kubandakanya nemodeli yokubuyiselwa. Xa kufanelekile, szoba ukuthelekisa kunye nokuthekisa kunye nokuvavanywa kusetyenziswa izixhasi zendalo (zokutya). Sikwashwankathela iziphumo ezixhasayo, okanye ezingavumiyo, ukuba kungenzeka ukuba i-BDNF kwimedical and orbital ye-PFC ilawule uphuhliso kunye nokugcinwa kwemikhwa yokuphendula kwempembelelo. Uphando olongezelelekileyo lunokuncedisa ekuphuhlisweni kweendlela zonyango zokunyanga ukuphazamiseka kokusetyenziswa kwecocaine.
IINKCUKACHA: Iziyobisi Isixhobo; Umsebenzi: I-Orbitof Pambal; I-prelimbic; ujongo ngqo uphononongo
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