Physiol Behav. I-2010 Oct 5; 101 (3): 394-400. doi: 10.1016 / j.physbeh.2010.07.005.
Rada P1, Bocarsly ME, IBarson JR, Hoebel BG, I-Leibowitz SF.
Abstract
Abantu abatyebileyo kunye nezilwanyana zibonisa ukusebenza kwenkqubo ye-dopamine (DA) kwi-nucleus accumbens (NAc). Umbuzo obhekiswe apha ngowokuba ingaba olu tshintsho kwi-NAc DA lunokufunyanwa na kwiigundane zeSprague-Dawley eziqhele ukutyeba kakhulu kukutya okunamafutha kodwa zikwisisindo esiqhelekileyo somzimba. Iigundane zahluthwa ngokwamaqela njenge "ukutyeba-kuthambile" (OP) okanye "ukunganyangeki ukutyeba" (OKANYE), ngokusekwe kubunzima babo ngexesha le-5days yokufikelela kukutya okunamafutha aphezulu, emva koko batshintshelwa kukutya okunamafutha asezantsi ngaphambili Uvavanyo lwe-microdialysis lwenziwa.
Iigundane ze-OP xa kuthelekiswa neegundane ezibonisiweyo zancitshiswa kakhulu kwinqanaba lesiseko le-DA kwi-NAc. Emva kwesidlo esinzima esinamafutha amaninzi, zombini i-OP kunye ne-rats zibonise ukunyuka okukhulu kwe-DA yangaphandle kunye ne-metabolites yayo; nangona kunjalo, i-NAc DA ye-RP yeerandi ihleli ikwamanqanaba ancitshisiweyo. Kwakhona ukunyuka kwe-DA kunye namanqanaba e-metabolite aqwalaselwe kwi-OR rats emva kokulawulwa kwenkqubo ye-emulsion yamafutha akubonakali kwiigundane ze-OP, kodwa endaweni yoko akubonisanga tshintsho kwi-DA kunye nokwehla kwemetabolites zayo. Ezi ziphumo zibonakalisa, okokuqala, ukuba amanqatha anokuvuselela ukukhululwa kwe-DA kwaye, okwesibini, ukuba iigundane ezikhutshiwe zithambekele ekuzondleni kakhulu kwaye zityebe kwinkqubo ethandekayo, yokutya okunamafutha kunciphise ukubonakaliswa kwenkqubo ye-mesolimbic ye-DA ngelixa isesiswini esiqhelekileyo, iphakamisa ukuba isenokuba kukunxulumana neendlela zabo zokuziphatha zokugqitha.
IINKCUKACHA: Intralipid; amanqatha; ukutyeba kakhulu; ukuxhathisa ukukhuluphala; i-rat; triglycerides
PMID: 20643155
PMCID: PMC2930885
DOI: 10.1016 / j.physbeh.2010.07.005
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