Neuroscience. 2006;139(3):813-20. Epub 2006 Feb 7.
IAvena NM1, Rada P, UMoses N, Hoebel BG.
Abstract
Ukusela isisombululo seswekile kwishedyuli ephakathi kunokukhuthaza ukutyiwa kweswekile kwaye kubangele iimpawu zokuxhomekeka ngelixa ukhulula i-dopamine ngokuphindaphindiweyo njengechiza lokuxhatshazwa. Kucingelwa ukuba incasa eswiti iyodwa yanele kwesi siphumo kwiimpuku zokuzinkcinkca nge-sucrose. Kwithiyori yokuba i-acetylcholine kwi-nucleus accumbens idlala indima kwi-satiety, iphinda icinge ukuba ukuhlanjululwa kwesisu kuya kulibazisa ukukhululwa kwe-acetylcholine. Iigundane ezine-gastric fistulas kunye ne-nucleus accumbens guide shafts ze-microdialysis zondliwa i-12 h ngosuku ngalunye. Ngethuba leyure yokuqala, i-fistulas yayivulekele iqela le-sham-feeding kwaye ivaliwe kwiqela le-real-feeding, kwaye i-10% ye-sucrose yayikuphela komthombo wokutya. Kwiiyure ezili-11 ezishiyekileyo, ukutya kweempuku ezingamanzi bekufumaneka kunye ne-10% yesucrose ukunika ukutya okunesondlo. Kwiimvavanyo ze-microdialysis ngexesha lesidlo sokuqala seswekile ngeentsuku ze-1, i-2 kunye ne-21, i-dopamine ye-extracellular yanda ubuncinane i-30% ngosuku ngalunye kumaqela omabini. I-acetylcholine yanda ngexesha lokutya kweswekile kwizilwanyana ezondla ngokwenene, kodwa kungekhona ngexesha lokutya kwe-sham. Ukuqukumbela, incasa yeswekile inokonyusa i-extracellular dopamine kwi-nucleus accumbens ngaphandle kokusilela kwizilwanyana kwirejimeni yokutya ebangela ukuzintyintya kunye nokuxhomekeka kweswekile. Ngexesha lokutya kwe-sham, isibonakaliso se-acetylcholine satiation siyasuswa, kwaye izilwanyana zisela ngakumbi. Ezi ziphumo zixhasa i-hypothesis yokuba i-dopamine ikhutshwa ngokuphindaphindiweyo ekuphenduleni incasa xa uzinkcinkca ngokutya okumnandi, kwaye umphumo we-acetylcholine satiety uyancipha kakhulu ngokuhlanjululwa; oku kunokuba yinto efanelekileyo kwi-bulimia nervosa ebantwini.
PMID: 16460879
DOI: 10.1016 / j.noscience.2005.12.037
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