Edlulileyo kwiMed. 2016 Aug 7. pii: S0091-7435 (16) 30215-8. doi: 10.1016/j.ypmed.2016.08.009.
Abstract
Zombini ukutshaya kunye nokutyeba zizinto ezibalulekileyo ezixhalabisa impilo yoluntu kwaye zinxulunyaniswa nomngcipheko wokufa kwangoko. Kusekwe kakuhle ukuba indlela ye-mesolimbic dopamine yinxalenye ebalulekileyo yenkqubo yomvuzo ngaphakathi kwengqondo kwaye ibandakanyeka kuphuhliso lomlutha. Ewe, inikotini kunye nokutya okunencasa kakhulu kuyakwazi ukuguqula ukukhutshwa kwe-dopamine ngaphakathi kwale nkqubo, kubangela umlutha njengeempendulo kubantu abasesichengeni. Nangona uphando olongezelelweyo lufanelekile, ukufunyaniswa kwezilwanyana kunye noncwadi lwabantu kuye kwacacisa ezininzi ze-neuroadaptions ezivela ekuvezweni kwe-nicotine kunye nokutya okunencasa kakhulu, okukhokelela ekuqondeni ngakumbi iindlela ezisisiseko ezinegalelo kolu kuziphatha olugwenxa. Kolu phononongo sibonisa iziphumo ezithatyathwe kuncwadi lwangaphambi kweklinikhi kunye neklinikhi yeziphumo ezaziwayo zokuvezwa kwi-nicotine kunye nokutya okunencasa kakhulu kwisekethe enxulumene nomvuzo ngaphakathi kwengqondo. Ngaphaya koko, sithelekisa i-neurobiological kunye nokuziphatha okugqithisayo phakathi kwe-nicotine, ukutya okunencasa kakhulu kunye nokutyeba kakhulu. Okokugqibela, sivavanya ibala elinxulunyaniswa nokutshaya, ukutyeba ngokugqithiseleyo kunye nokukhotyokiswa kokutya, kunye neziphumo zokubekwa ibala kwimpilo yonke kunye nempilo yomntu.
IINKCUKACHA: iDopamine; Ukuxhatshazwa kokutya; Ukutya okunencasa kakhulu; Inikotini; Ukutyeba ngokugqithiseleyo
PMID: 27509870
DOI: 10.1016/j.ypmed.2016.08.009
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