AMANQAKU: Funda ngezifundo ezinesidubedube (umlukumezi / ngesondo) uxela utshintsho lwe-epigenetic olubonakalayo olwenzeka kwiziselo ezinxilisayo. Utshintsho lwe-epigenetic lwenzeka ngohlobo olunxulumene nenkqubo ye-oxetocin (ebaluleke kuthando, ukubopha, ukuchasana, uxinzelelo, njl. Njl.). Amagqabantshintshi:
- Ukwabelana ngesondo / iziyobisi kwi-epigenetic markers yenkqubo yengqondo ye-oxytocin ijongeka ngokufana notywala
- Iziphumo zophando zihambelana Kuhn kunye neGallinat, I-2014 (isifundo esidumileyo se-fMRI kubasebenzisi be-porn)
- Iziphumo zinokubonisa isistim yoxinzelelo lwendlela yokusebenza (olu lutshintsho oluphambili kumlutha)
- Utshintsho kwiintlobo ze-oxytocin zinokuchaphazela ukubopha, uxinzelelo, ukusebenza ngokwesondo, njl.
Ngakumbi, funda eli nqaku libekekileyo: Iinzululwazi zichonga iihormoni ezinokubangelwa kukuphazamiseka kwengqondo
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UAdrian E. Boström, Andreas Chatzittofis, Diana-Maria Ciuculete, John N. Flanagan, Regina Krattinger, Marcus Bandstein, Jessica Mwinyi, Gerd A. Kullak-Ublick, Katarina Görts ,berg, Stefan Arver, Helgi B. Schiöth kunye noJussi Jokinen (2019 )
I-Epigenetics, DOI: https://doi.org/10.1080/15592294.2019.1656157
Abstract
Isifo i-Hypersexual disorder (HD) saphakanyiswa njengesifo kwiDSM-5 kwaye ukuhlelwa 'Isinyanzeliso seNzondo sokuziphatha ngokwesondo' ngoku kuboniswa njengokuphazamiseka kolawulo lwe-ICD-11. I-HD ibandakanya iindlela ngeendlela zenzululwazi ye-pathophysiological; kubandakanya ukunganyanzelekanga, ukunyanzelwa, umnqweno wesondo kunye nokulutha ngokwesini. Akukho sifundo sangaphambilini esaphandwa kwi-HD kuhlalutyo lwe-methylation limited kwi-microRNA (miRNA) ezinxulumene ne-CpG. Iphethini ye-genome wide methylation yalinganiswa kwigazi elipheleleyo ukusuka kwizifundo ze-60 ezine-HD kunye nama-33 amavolontiya asempilweni asebenzisa i-Illumina EPIC BeadChip. I-8,852 miRNA ehambelana ne-CpG-sayithi iphandwe ngohlalutyo oluninzi lomgca wokuhlalutya kwemethylation M-amaxabiso kumgangatho wokuzimele geqe wesifo (HD okanye ivolontiya elisempilweni), ulungelelwaniso lwe-covariates ezimiselwe ngokugqibeleleyo. Amanqanaba okuchaza ama-miRNA omgqatswa aphandwe ngabantu abafanayo kuhlalutyo lwentetho ehlukileyo. Umgqatswa we-methylation loci waphinda wafundelwa umbutho kunye nokuxhomekeka kotywala kwi-cohort ezimeleyo yezifundo ze-107. Indawo ezimbini zeCpG zazinomda obalulekileyo kumda we-HD - cg18222192 (MIR708) (p <10E-05,pFDR = 5.81E-02) kunye cg01299774 (MIR4456) (p <10E-06, pFDR = 5.81E-02). I-MIR4456 yayisezantsi kakhulu ibonakaliswe kwi-HD kuzo zombini i-univariate (p <0.0001) kunye ne-multivariate (p <0.05) yohlalutyo. Amanqanaba e-Cg01299774 e-methylation adityaniswa ngokungahambelani kunye namanqanaba okubonisa e-MIR4456 (p <0.01) kwaye ayekwahlulahlulwa ngokwahlukeneyo ekuxhomekekeni kotywala (p = 0.026). Ukuqikelela ekujoliseni i-Gene kunye nohlalutyo lwendlela kutyhile ukuba i-MIR4456 ibeka ngokwenyani iintlobo zofuzo ezichazwe ngokukhethekileyo kwingqondo kwaye zibandakanyeka kwiindlela eziphambili zeemolekyuli ekucingelwa ukuba kufanelekile kwi-HD, umzekelo, indlela yokubonisa ye-oxytocin. Isishwankathelo, isifundo sethu sinyanzelisa igalelo elinokubakho le-MIR4456 kwi-pathophysiology ye-HD ngokuchaphazela ukubonakaliswa kwe-oxytocin.
UKUSUSELA kwiQelana
Kuhlalutyo lomanyano lweDNA methylation kwigazi elisecaleni, sichonga iindawo ezinobuchule zeCpG ezinxulunyaniswa neMIR708 kunye neMIR4456 ephawuleka ngokungafaniyo kwi-methylated kwizigulana ze-HD. Ukongeza, sibonisa ukuba i-hsamiR- 4456 edibene ne-methylation locus cg01299774 ngokwahlukileyo kwi-methylated kuxhomekeko kotywala, iphakamisa ukuba ngokuyintloko inokunxulunyaniswa necandelo lomlutha elibonwe kwi-HD.
Kulwazi lwethu, akukho phepha langaphambili elichaze ukubaluleka kweMIR4456 kwimeko ye-psychopathologies. Sichonga ukuba le miRNA ilondolozwe ngokwendalo ngokubhekisele kulwakhiwo lokuqala kunye nolwakhiwo lwesakhiwo esingemva kweenwele ezisuka ekusekweni kweprates. Ukongeza, sinika ubungqina bokuba iithagethi ze-mRNA ezijolise kwi-MIR4456 zichazwe ngokukhethekileyo kwi-amygdala kunye ne-hippocampus, imimandla emibini yobuchopho ephakanyiswe nguKühn et al. Ukunyanzeliswa kwi-pathophysiology ye-HD [5].
Ukubandakanyeka kwendlela yokubonisa ye-oxetocin echongiweyo kolu phononongo kubonakala kunempembelelo enkulu kwiimpawu ezininzi ezichaza i-HD njengoko kucetywayo nguKafka et al. [I-1], ezinje ngomnqweno wesondo, ukunyanzelwa, ukungaziphathi kunye (nokwabelana ngesondo). Ngokuyintloko iveliswe yiyunithi ye-patriometri ye-hypothalamus kwaye ikhutshwe yi-posterior pituitary, i-oxetocin inendima ebalulekileyo kukuqhina kwentlalo kunye nokuzala ngokwesondo kuwo onke amadoda kunye nabasetyhini [59]. UMurphy et al. ichaze amanqanaba aphezulu ngexesha lokuvuselela ngokwesondo [60]. Burri et al. ifumanise ukuba isicelo se-orantocin se-intranasal emadodeni sakhokelela ekonyukeni kwamanqanaba e-plasma ye-epinephrine ngexesha lokulala kunye nokuqonda okuguqukayo kwe-arousal [61] Ukongeza, i-oxytocin icetyisiwe ukuthintela umsebenzi we-axothalamic-pituitary-adrenal (HPA) axis ngexesha loxinzelelo. UJurek et al. uqaphele ukuba i-oxytocin receptormediated intracellular mechanisms ihlehlise ukuhanjiswa kwe-corticotropin-releasing factor (Crf) kwindawo ye-patrericular nucleus, iseli enxulumene ngamandla neempendulo zoxinzelelo [62].
Utshintsho kwindlela ye-oxetocin esayina indlela inokuchaza into efunyenwe nguChatzittofis et al., Owagqala ukungasebenzi kwe-axel ye-HPA emadodeni ane-hypersexual disorder [3]. Ngapha koko, izifundo zibonisa ukuba i-oxytocin inokubandakanyeka kwi-pathophysiology ye-obsessive-kunyanzeleko ukuphazamiseka [63]. Ukudibana kwe-oxytocin nenkqubo ye-dopamine, i-HPA-axis kunye nenkqubo yomzimba yokuzikhusela ekhokelele kwisibhengezo sokuba ukungafani komntu ngamnye kumanqanaba e-oxetocin kunefuthe kubuthathaka [64]. Ngelixa i-oxetocin ibikhe yadityaniswa ngaphambili nolawulo lwendlela yokuziphatha neyolunya, uJohansson et al. saqhubeka sibonisa ukuba ukwahluka kwemfuzo kwi-oxetocin receptor gene (OXTR) nefuthe kwisimo sokusabela kwiimeko ezinamanqanaba aphezulu omsindo phantsi kwempembelelo yotywala [65]. Okokugqibela, uBrüne et al. wagqiba kwelokuba ukwahluka kwemfuza kwi-OXTR kunokuba negalelo ekuchazeni i-pathophysiology ye -lineline botho disorder [66], i-pathology yempawu ebonakaliswa kukungazinzisi okunzulu [dysregulation] [66].
I-MIR4456may inomsebenzi owongezelelweyo olawulayo kwi-HD engakhange ityhilwe kufundo lwangoku. Ngokuhambelana nokufunyenweyo, izifundo zangaphambili zichaze unxibelelwano lokuziphatha kakubi ngokwesondo kwamadoda kunye nohlobo olubandakanyeka kwinkqubo ye-glutamatergic kubantu abadandathekileyo [67]. Ngapha koko, indima enokubakho ye-3'-5'-cyclic adenosine mono phosphate (cAMP) amanqanaba okwabelana ngesondo aboniswa kwiigundane zabasetyhini, ngokumodareyitha i-phosphoprotein- 32 kunye nokukhokelela kwiinguqu ze-progestin receptors [68]. Into ebangela umdla kukuba i-cAMP ikwalawula iimolekyuli ezinxulumene nesikhokelo se-axon [69], esinjenge-B3gnt1 gene, eyayinxulumene nokuziphatha okubi ngokwesini kwiimpuku zesilisa
INQAKU LOKUQALA LOKUFUNDA:
Iinzululwazi zichonga iihormoni ezinokubangelwa kukuphazamiseka kwengqondo
Isifundo esitsha samadoda nabasetyhini abanesifo seengcongconi sibonisa ukuba inokwenzeka indima yehomoni ocintocin, ngokweziphumo ezipapashiweyo kwijenali. Epigenetics. Iziphumo ezifumanekayo zinokuvula iminyango yokunyanga esi sifo ngobunjineli ngendlela yokucinezela ukusebenza kwawo.
Isifo esixhalabisayo, okanye ukuqhuba ngesondo okuxhaphakileyo, kuthathwa njengokungxamiseki kokuziphatha ngokwesini, kudweliswe njengesiphazamiso-kulawulo lwempembelelo nguMbutho wezeMpilo weHlabathi. Inokubonakaliswa ziingcamango eziqaphelekayo zesini, ukunyanzelwa ukuba wenze izenzo zesondo, ukuphulukana nolawulo, okanye imikhwa yesini ethwala iingxaki okanye umngcipheko. Ngelixa kuqikelelwa ubukho bezinto ezahlukileyo, uncwadi lubonisa ukuba ukuphazamiseka kwengqondo ngokuchaphazela i3-6% yabemi.
Impikiswano ijikeleze ukufunyaniswa kwesifo ngenxa yokuba ihlala yenzeka kunye neminye imiba yempilo yengqondo, ukucebisa ukuba inokuba isolwandiso okanye ukubonakaliswa kokuphazamiseka kwengqondo okukhoyo. Kancinci kuyaziwa malunga ne-neurobiology esemva kwayo.
Umbhali okhokelayo u-Adrian Boström ovela kwiSebe leNeuroscience kwiYunivesithi yaseUppsala, eSweden wathi: "Sizimisele ukuphanda iinkqubo zolawulo lwe-epigenetic emva kwe-hypersexual disorder ukuze sikwazi ukubona ukuba ingaba inezimpawu ezithile ezenza yahluke kwezinye iingxaki zempilo." funda nabaphandi abavela kwiQela lezeMpilo lezeSondo (i-ANOVA) eKarlinska Institutet, eStockholm, eSweden.
"Kulwazi lwethu, isifundo sethu sesokuqala ukubonakalisa ukungasebenzi kakuhle kwe-epigenetic ye-DNA methylation kunye nomsebenzi we-MicroRNA kunye nokubandakanyeka kwe-oxytocin kwingqondo phakathi kwezigulana ezifuna unyango lwe-hypersexual."
Oosonzululwazi balinganisa iipateni ze-methylation ze-DNA esegazini ezivela kwizigulana ze-60 ezine-hypersexual disorder kwaye bazithelekisa neesampulu ezivela kumavolontiya ase-33 anempilo.
Baphanda imimandla ye-8,852 ye-DNA methylation enxulumene ne-microRNAs ekufutshane ukuba ichonge umahluko phakathi kweesampulu. I-methylation ye-DNA inokuchaphazela ukubonakaliswa kwemfuza kunye nokusebenza kwemfuza, idla ngokusebenza ukunciphisa inkqubo yazo. Apho kufunyenwe utshintsho kwi-methylation ye-DNA, abaphandi baphanda amanqanaba okubonisa uhlobo lwe-microRNA ehambelana noko. Ii-MicroRNAs zinomdla ngokukhethekileyo njengoko zinokudlulisa isithintelo segazi-ingqondo kunye nokuguqula okanye ukudodobalisa intetho eya kuthi ga kumakhulu aliqela ohlobo oluthile kwingqondo nakwamanye izicubu.
Baphinde bathelekisa iziphumo zabo kwiisampuli ezivela kwizifundo ze107, i-24 yayixhomekeke kubo butywala, ukuphonononga umbutho nokuziphatha okukhohlakeleyo.
Iziphumo zachonga imimandla emibini ye-DNA eguqulweyo kwizigulana ezinesifo sokuphazamiseka kwengqondo. Umsebenzi oqhelekileyo we-DNA methylation waphazamiseka kwaye i-microRNA ehambelana nayo, ebandakanyeka ekuthuliseni uhlobo, kwafunyaniswa ukuba ibonakalisiwe. Uhlalutyo lubonakalise ukuba i-microRNA echongiweyo, i-microRNA-4456, ijolise kwiintlobo zemvelo ezibonakala ngokucacileyo kumanqanaba aphezulu kwingqondo kwaye zibandakanyeka kummiselo wehomoni oxytocin. Ngokupheliswa kwe-gene kuncitshisiwe, i-oxytocin inokulindeleka ukuba ibe kumanqanaba aphezulu, nangona isifundo sangoku singakuqinisekisi oku.
Kubonakale kudidi oluthile lwe-vole kunye ne-primate. I-neuropeptide oxytocin idlala indima ephambili kulawulo lokuzibopha kunye. Izifundo zangaphambili zibonakalise ukuba i-oxetocin inxulunyaniswa nommiselo wentlalo kunye nokubhanxana, ukuzala ngokwesondo kunye nokuziphatha okukhohlakeleyo kumadoda nabasetyhini. Ukuthelekisa nezifundo ezixhomekeka etywaleni kubonise ukuba le ngingqi ye-DNA ingaphantsi kwe-methylated, icebisa ukuba inokuthi inxulunyaniswe ikakhulu nezixhobo ezinoburharha, njengokulukuhla ngokwesondo, umnqweno wesondo, ukunyanzelwa kunye nokuxhotyiswa.
"Olunye uphando luya kufuneka ukuphanda indima ye-microRNA-4456 kunye ne-oxytocin kwisifo se-hypersexual, kodwa iziphumo zethu zibonisa ukuba kunokuba kufanelekile ukujonga izibonelelo zamachiza kunye nonyango lwengqondo ukunciphisa umsebenzi we-oxytocin," utshilo uNjingalwazi uJussi Jokinen waseUmea KwiYunivesithi, eSweden.
Ababhali baqaphela ukuba isithintelo sophando kukuba umahluko obonakalayo kwi-methylation ye-DNA phakathi kwabaguli abanesifo sokungasebenzi kakuhle kunye namavolontiya asempilweni ayephelela nje kwi-2.6%, ngoko ke ifuthe lokutshintsha komzimba linokubizwa. Nangona kunjalo, umzimba okhulayo weziphakamiso zobungqina eziguqula nje i-methylation efihlakeleyo inokuba neziphumo ezibanzi zeemeko ezinzima ezinje ngexinzelelo okanye i-schizophrenia.
###
Olu phando lwalunikwe inkxaso-mali ngesivumelwano sengingqi phakathi kweYunivesithi yase-Umeå kunye neVästerbotten County Council (ALF) kunye nezibonelelo ezibonelelwe liBhunga leStockholm County ngokunjalo neSweden Research Foundation, i-Åhlens Foundation, iNovo Nordisk Foundation, kunye neSweden Brain Research. Isiseko.
INQAKU LESIBINI NGOKUFUNDA:
Utshintsho lwe-Epigenetic oludityaniswe neNtsholongwane ye-Hypersexual Disfer and Behaviors
UgqirhaResearch.com Udliwanondlebe no: Adrian E. Boström MD, egameni lababhali
ISebe le-Neuroscience, iYunivesithi i-Uppsala, iSweden
MedicalResearch.com: Yintoni imvelaphi yolu phononongo?
Impendulo: Ngelixa kuqikelelwa ubukho jikelele, uncwadi lubonisa ukuba i-hypersexual disorder (HD) ichaphazela i-3-6% yabemi. Nangona kunjalo, impikiswano ijikeleze isifo kwaye kuncinci okwaziwayo malunga ne-neurobiology engemva kwayo.
Isifo se-Hypersexual disorder khange siphandwe ngaphambili ngokubhekisele kwi-epigenomic kunye ne-transcriptomics kwindlela yokufunda simahla kwaye akukho nto ingako iyaziwayo malunga ne-neurobiology ebangela esi sifo. Siphonononge ukuba ngaba alukho na utshintsho lwe-epigenetic oluchaphazela imisebenzi yemfuza kunye nokubonisa kwizigulana ezi-hypersexual (HD) kwaye sichonge i-microRNA edibeneyo ekholelwa ukuba inefuthe kwindlela yokusebenza kwehomoni i-oxytocin kwingqondo.
I-Oxytocin yaziwa ngokuba nefuthe elibanzi lokuziphatha. Ngokolwazi lwethu, akukho sifundo sangaphambili esasinike ubungqina bokunxibelelana phakathi kwe-methylation ye-DNA, umsebenzi we-microRNA kunye ne-oxytocin kwisifo se-hypersexual. Iziphumo zethu zilungele ukuqhubeka nophando kwindima ye-MIR4456 kwaye ngakumbi i-Oxytocin kwisifo sehypersexual. Izifundo ezithe kratya ziyafuneka ukuqinisekisa indima ye-Oxytocin kwi-HD kunye nokuphanda ukuba ngaba unyango lwe-oxytocin antagonist yonyango lwamachiza lunokuba neziphumo ezilungileyo kwizigulana ezinengxaki yokuxhalaba.
MedicalResearch.com: Zithini iziphumo eziphambili?
Impendulo: - Kolu phando senze uphando ngaphezulu kwe-8000 eyahlukileyo i-methylation ye-DNA elandelelaniswe ngendlela engenasiphene kwaye ngaloo ndlela ingalunganga. Ke ngoko, besinomdla kwaye simangalisiwe kukuchonga okungena ngqo kwi-genRNA ejolise ngqo kwisifo esichazwe kwingqondo kwaye zibandakanyeka kwiindlela ezinkulu zeemolekyuli zeemolekyuli ekucingelwa ukuba zilungele ukuphazamiseka kwengqondo, umz. Oku microRNA ikwabonakala ngathi yindaleko egcinwe kuyo yonke inyani, ekwanomdla kunye nokufumana okungalindelekanga.
MedicalResearch.com: Yintoni ekufuneka bayithathile abafundi kwingxelo yakho?
Impendulo: Isidubedube Hypersexual sibandakanya iindlela ezahlukeneyo pathophysiological kubandakanya ukunyanzeliswa, ukunyanzeliswa, umnqweno wesondo kunye nokulutha ngokwesini. Oku kunokutolikwa njengokuthi isifo sokungasebenzi kakuhle emzimbeni (Hypersexual disorder) siqukethe izinto ezihlaselayo, kodwa singabonakali njengesiyobisi kuphela. Iziphumo zethu, ekukhanyiseni kwe-crossover ngokuxhomekeka kotywala, cebisa ukuba i-MIR4456 kunye ne-oxytocin signalingwaywaywayitha ingabandakanyeka ngokuyintloko kwecandelo lokulutha le-hypersexual disc. Izifundo ezingaphezulu ziyafuneka ukukuqinisekisa ngokupheleleyo oku.
MedicalResearch.com: Zeziphi izindululo onazo zophando lwexesha elizayo ngenxa yalo msebenzi?
Impendulo: Iziphumo zethu zikhuthaza ukuqhubeka kophando ngokusebenza, umzekelo, i-oxytocin elawula unyango lweziyobisi kwi-hypersexual disorder enokuba negalelo kukhetho lonyango lwenoveli ukuphucula isiphumo seklinikhi sabo bachaphazelekayo. Ukongeza, sichonga i-microRNA ethile (miRNA) apho i-miRNA yexesha elizayo elawula iziyobisi inokuvavanywa kwisifo se-hypersexual.
I-MedicalResearch.com: Ngaba ikhona enye into onqwenela ukuyongeza?
Impendulo: I-DNA yethu yikhowudi yemfuza eyaguqulela ngokulandelelana kwee-amino acid ezibizwa ngokuba ziiproteni. Iiproteni, zona, zenza eyona nto ichaza zonke izinto eziphilayo. I-DNA yethu izuzwe njengelifa kwaye ayitshintshi ngokuhamba kwexesha. Olu phononongo, nangona kunjalo, luqulathe i-epigenetics, olo lutshintsho oluchaphazela ukusebenza kofuzo kunye nokubonisa. Le misebenzi ye-epigenetic iyatshintsha ngokuhamba kwexesha kwaye inokulawulwa sisifo esithile kwizifo ezithile. Kukho iindlela ezahlukeneyo ze-epigenetic.
Kolu phando, sifunde i-methylation ye-DNA (inkqubo eyaziwayo ukuba nefuthe ekubonakalisweni kofuzo, oko kukuthi, ubungakanani bemfuza eguqulelwa kwiprotein) kunye nomsebenzi we-microRNA (amacandelo amafutshane angabhaliswanga wofuzo anokuchaphazela ukuguqulelwa kwamakhulu aliqela. iintlobo ezahlukeneyo).
Ukuthelekisa abaguli abanesifo esiyi-hypersexual ukuya kumavolontiya asempilweni, sichonge ukulandelelana kwe-methylation ngokulandelelana ukuba kutshintshwe kakhulu kwisifo sehypersexual. Ukuqinisekisa ukubaluleka koku kufunyanwa, ulandelelwano olufanayo lwe-DNA lwaphinda lwabonakaliswa ukuba luyekisiwe kwizifundo ezinokuxhomekeka kutywala, ukucebisa ukuba inokunxulunyaniswa ikakhulu necandelo lokulutha lokuphazamiseka kwengqondo. Ulandelelwano lwe-methylation ye-DNA echongiweyo yayinxulunyaniswa ne-microRNA ebizwa ngokuba yi (microRNA 4456; MIR4456), kwaye olunye uhlalutyo lubonise ukuba oku kulandelelana kwe-methylation ye-DNA kunefuthe kubungakanani be-MIR4456 evelisiweyo. Ngaphaya koko, kwiqela elinye lokufunda, sibonisa ukuba i-MIR4456 ikwindawo ephantsi kakhulu kwisifo se-hypersexual xa kuthelekiswa namavolontiya asempilweni, icebisa ngamandla ukuba kuguqulwe iipateni ze-methylation ye-DNA kwimpembelelo yokuphazamiseka koxinzelelo kunye nokufaka igalelo ekuchazeni ukungaboni kakuhle kweMIR4456. Njengoko i-microRNA: s ithiyori iyakwazi ukujolisa kumakhulu aliqela ohlobo, sisebenzise ii-algorithms zekhompyuter ukuveza ukuba i-MIR4456 ijolise kwimfuza echazwe ngokukhethekileyo kwingqondo kwaye ibandakanyeka kwiindlela ezinkulu zeemolekyuli ekucingelwa ukuba zilungile kwi-HD, umzekelo, i-oxetocin indlela yokubonisa. Iziphumo zethu zilungele ukuqhubeka nophando kwindima ye-MIR4456 kwaye ngakumbi i-Oxytocin kwisifo sehypersexual. Izifundo ezithe kratya ziyafuneka ukuqinisekisa indima ye-Oxytocin kwi-HD kunye nokuphanda ukuba ngaba unyango lwe-oxytocin antagonist yonyango lwamachiza lunokuba neziphumo ezilungileyo kwizigulana ezinengxaki yokuxhalaba.
Nangona kunjalo idatha engashicilelwanga eyenzelwe isifundo esahlukileyo sokulandelelana ibonisa ukonyuka okubonakalayo kumanqanaba e-Oxytocin kwizigulana ezinengxaki yokuxhatshazwa ngokwesini xa kuthelekiswa nolawulo, kunye nokwehliswa okukhulu kwamanqanaba e-oxytocin emva konyango lweCognitive Behaeve Therapy, ebonisa ukuba indima ye-Oxytocin Ukuphazamiseka koxinzelelo ngokwesini kunye nokwenza amabango athiwe thaca kolu phando ngakumbi. Ezi ziphumo zokuqala zinikezelwe njengepowusta yokuqhekeza kade kuMbutho we-Biological Psychiatry intlanganiso ngoMeyi 2019 kwaye ikwangeniswa njengepowusta kwi-ACNP ngoDisemba 2019.
Citation:
UAdrian E. Boström et al, Hypermethylation-ehambelana nokwehliswa kwe-microRNA-4456 kwisifo se-hypersexual kunye nefuthe le-putative kwi-oxytocin signaling: Uhlalutyo lwe-methylation ye-DNA yemfuza ye-miRNA, Epigenetics (2019). INGXELO: 10.1080 / 15592294.2019.1656157
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