Acta Neurobiol Exp (IiMfazwe). 2007;67(4):481-8.
Abstract
I-Dopaminergic neurons ye-midbrain ngowona mthombo uphambili we-dopamine (DA) engqondweni. I-DA ibonakaliswe ukuba ibandakanyeka kulawulo lweentshukumo, ukubonakaliswa kwempazamo kuqikelelo lomvuzo, inkuthazo, kunye nokuqonda. Ukuncipha kweCerebral DA luphawu lwesifo sikaParkinson (PD). Amanye amazwe e-pathological nawo aye anxulunyaniswa nokungasebenzi kakuhle kwe-DA, okufana ne-schizophrenia, i-autism, kunye nokusilela kwengqwalasela ebantwaneni, kunye nokusetyenziswa gwenxa kweziyobisi. I-DA inxulunyaniswe ngokusondeleyo neendlela zokuziphatha ezifuna umvuzo, ezinje ngokusondela, ukusetyenziswa, kunye nokuba likhoboka. Uphando lwakutsha nje lucebisa ukuba ukudutyulwa kwe-DA neurons yinto ekhuthazayo njengesiphumo sokulindela umvuzo. Le ngqikelelo isekwe kubungqina bokuba, xa umvuzo umkhulu kunokuba bekulindelwe, ukudutyulwa kwee-neurons ezithile ze-DA kuyenyuka, nto leyo eyandisa umnqweno okanye inkuthazo kumvuzo.
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