Ingabe ukushaya indlwabu kakhulu kunciphise amazinga ami e-testosterone?

Impendulo: Ukuphazamiseka kobufakazi bathi lokhu akunakwenzeka kakhulu.

Funda le ngqungquthela ukuze uthole okushiwo ngemiphumela ye-ejaculation: Amadoda: Ingabe Ukunyakaza Okuvamile Kwenzeka I-Hangover?

Akumangazi ukuthi abasebenzisi abaningi be-porn abasindayo abathuthukisa ukusola ukungasebenzi kahle kwe-erectile ukuthi ukushaya indlwabu kwehlise amazinga abo e-testosterone. Abesilisa abathumela ezinkundleni bavame ukusho okufana nokuthi, “Zonke izivivinyo zami zomsebenzi zabuya ezijwayelekile, kufaka phakathi amazinga T, ngakho udokotela wanginika i-Viagra. "

Okokuqala, akuvamile ukuthi i-ED emadodeni amancane ibangelwe yi-testosterone ephansi. Okwesibili, abesilisa abane-ED eyenziwe ngocansi babika njalo amazinga e-testosterone ajwayelekile, kepha basebenze ngokusobala ekujuleni okukhulu. Ngaphezu kwalokho, izifundo zibika amazinga afanayo we-testosterone emadodeni nakwabesilisa abaphilile abane okungapheliyo ED (1, 2, 3, 4). Kulezi zifundo eziningi ezixoxwe ngezansi, kanye nobufakazi be-anecdotal, singaphetha ngokuthi:

  • i-testosterone ephansi ayivami ukubandakanyeka ku-ED osemusha
  • Ukuvama kwe-ejaculation ayinamthelela emazingeni e-testosterone.

Kalula nje, asibazi ubufakazi bocwaningo (okwamanje) obubeka i-testosterone ephansi emiphumeleni emibi ebikiwe yokusetshenziswa kocansi / ukushaya indlwabu. Empeleni, ubufakazi imvamisa ikhomba kumjikelezo womvuzo wobuchopho kanye ne-hypothalamus njengabadlali abaphakathi ezimpawu ezihlobene nezocansi, kanye nokungasebenzi kahle kocansi okubangelwa ucansi. Bheka le vidiyo ukuze uthole imininingwane.

Lokhu akusho ukuthi ezinye izinguquko zobuchopho ezenziwe ngocansi azikwazi ukushintsha ama-hormone ajikelezayo. Kungenzeka ukuthi bayakwenza, njengoba izidakamizwa ziguqula ukujikeleza komvuzo, okungathinta amasistimu wokulawula ama-hormonal aphansi. Isimo samanje sesayensi:

  1. I-testosterone "ayisetshenziswanga" nge-ejaculation noma ukushaya indlwabu, noma kunjalo testosterone receptors ingase inqatshelwe izinsuku ezingu-3-4 ngemva kokukhishwa kwe-ejaculation.
  2. Izifundo kokubili ukuzithiba futhi "ukuxoshwa ekuqedeni ngokocansi”Khombisa ukuthi akunamphumela kumazinga we-testosterone.
  3. Eqinisweni, abalobi be lolu cwaningo futhi lolu cwaningo siphakamisa ukuthi ukuziyeka kungase kuholele emazingeni ephansi e-testosterone.
  4. Akukho ukulungiswa okuqhubekayo phakathi komsebenzi wobulili, noma ukuziyeka, namazinga e-testosterone e-plasma - ngaphandle kwe i-spike yosuku olulodwa (46% ngenhla kwesisekelo) kulandela izinsuku eziyisikhombisa zokuyeka. Ngemuva kosuku olulodwa lwe-spike testosterone lubuyele kwesisekelo kuze kube sekupheleni kokuhlolwa ngosuku lwe-16.
  5. Kodwa-ke, kunobufakazi bokuthi ukujula kuze kube seqophelweni le- ukuxubana ngokocansi kubangela izinguquko eziningi zobuchopho - kufaka phakathi i- ukwehla kwe-androgen receptors futhi a ukwanda kuma-receptors e-estrogen ezindaweni eziningana zobuchopho. Ukuvuselelwa kwesifiso sobulili okugcwele kuthatha izinsuku ezingu-7-15 futhi ngempela ngaphandle kokushintsha kobuchopho obuhlobene nokulutha.
  6. I-ED eyenziwe nge-Porn ayihlangene namazinga we-testosterone yegazi. Ubufakazi be-anecdotal, izifundo ezingenakubalwa ze-ED, kanye ne-erectile physiology konke kuyakuphikisa lokhu. Bona le ngxoxo nguprofesa we-endocrinology yokuzala - I-Hypogonadal amadoda kanye nokuhlelwa
  7. Akukho ukulungiswa okuqhubekayo phakathi komsebenzi wobulili, noma ukuziyeka, namazinga e-testosterone e-plasma - ngaphandle kwe i-spike yosuku olulodwa (46% ngenhla kwesisekelo) kulandela izinsuku eziyisikhombisa zokuyeka. Okubanzi ukushintshashintsha kwamazinga we-testosterone wesilisa (10-40%) ejwayelekile.
  8. Akunabufakazi bokuyeka ukukhulisa amazinga e-testosterone. Izifundo ezimbili kuphela ezilinganise amazinga we-T ngesikhathi sokuziyeka isikhathi eside - futhi zombili azitholanga shintsho:
    1.  “Odumile” Ukutadisha kwaseChina Amanani we-T alinganisiwe nsuku zonke izinsuku ze-16, futhi ngithole ukwanda okuncane kuze kube usuku lwe-6 - nokubuyela kwisisekelo (kancane ngezansi) kusuka ngosuku 8 kuya ngosuku 16 lapho ukuhlolwa kuphelile.
    2. Ucwaningo ku-#4
  9. Lokhu abstract - Impendulo ye-endocrine ku-orgasm ekwenyelwa ukushaya indlwabu emadodeni aphilile ngemuva kokuqeda ukulala ngokocansi nge-3, lapho izifundo zingazange ziphume amasonto ama-3, kuvame ukucashunwa njengobufakazi bokuthi ukuzithiba kuholela ekwandeni kwe-testosterone. Akukwenzi. Lesi sigwebo esivela ku-abstract asinamagama abizayo futhi siyadukisa: “nakuba i-testosterone ye-plasma yayingavunyelwanga nge-orgasm, izici eziphakeme ze-testosterone zaqaphela ngemva kwesikhathi sokuzilahla“. Kuhlelo isifundo esigcwele, amazinga e-testosterone afana nalawo maqembu amabili. Hlola igrafu ye-testosterone C on ikhasi 379. Qaphela amazinga e-testosterone ekuqaleni kwefilimu (uphawu lwemizuzu eyi-10) ayefana kuwo womabili amaqembu. Ukuphela kwendaba. Ulimi oludidayo kokungabonakali lisho umehluko we-testosterone ngenkathi ushaya indlwabu. Ngenkathi ubuka ifilimu evusa inkanuko nokushaya indlwabu, amazinga e-T ehle ngeseshini yokushaya indlwabu ngaphambi kokuyeka. Ngemuva kwezinsuku ezingama-21 zokuyeka, amazinga we-T ahlala eduze kwesisekelo semizuzu eyi-10 ngesikhathi sokushaya indlwabu. Isitatimende - “ukuhlolwa kwe-testosterone ephakeme kwaqaphela emva kwesikhathi sokuziyeka”- kusho ukuthi amazinga e-testosterone awazange awe kakhulu ngesikhathi sokugqugquzela: ukushaya indlwabu nokubukwa kocansi. Ababhali basikisela ukulindela ukubukela i-porno (mhlawumbe eyongezwe ngokulindela ekugcineni ukushaya indlwabu) kubangele ukuthi i-testosterone ihlale iphakeme kukho konke ukubuka.
  10. Izifundo zezintambo ngokungaguquguquki ukuthola ukuthi ukujula "ekukhathaleni ngokocansi" akunamthelela emazingeni e-testosterone. Lezi zifundo zilandela izilwane kuze kube yizinsuku eziyi-15. Kodwa-ke, bathola izinguquko eziningi ngaphakathi kohlelo lwe-limbic, kufaka phakathi ukwehla kwama-androgen receptors, nokwanda kuma-estrogen receptors & opioids (avimba i-dopamine), kanye nezinguquko ekubonakalisweni kofuzo.
  11. Isikhati eside izifundo eziphathelene nezilwane ababonisi ukuhlanganiswa okuthembekile phakathi kwamazinga ejaculation nama-blood testosterone.
  12. Ngendlela, amazinga e-testosterone kuvame ukuguquka kusuka ku-10-40%.
  13. Lokhu isifundo esisodwa kusuka ku-1974 kubike imisebenzi emincane yezocansi ehambisana ne-testosterone ephakeme - kwezinye izifundo, kepha hhayi zonke. Kodwa-ke, ucwaningo luye lwathola nokuthi amazinga aphezulu we-testosterone ahlotshaniswa nezikhathi zokwenza ucansi. Kuyaphikisana kancane. Masibeke lesi sifundo kumongo: Asikaze siphindwe futhi siqukethe okuguquguqukayo okungalawuleki okungenakubalwa. Zonke ezinye izilwane nezifundo zabantu ezihlola i-testosterone nobuningi be-ejaculation, ukuziyeka, amazinga ahlukahlukene wezenzo zocansi, kanye nokungasebenzi kahle kwe-erectile kuphikisa okutholakele.

Vala, ubuhlobo obuthembekile futhi ukuziphatha okuzibophezelayo, njengokuya ocansini ngokwayo, ukwandisa impilo yonke, ukuhlukaniswa noma ukunye izinto zokuphila kokusetshenziswa kwezilonda ezisindayo kungenzeka ngokungaqondile ukucindezela amazinga e-testosterone, nge-epigenetics noma ezinye izici ezishintsha ukusebenza kweseli.

Nansi ingxenye yokushintshana ngamazinga we-testosterone nama-anabolic steroids angaba nentshisekelo kubavakashi abakha umzimba. Qaphela: Umsebenzisi we-steroid angaba umlutha we-steroids. Ngisho nokuhlolwa okumbalwa kwamagundane, okungenandaba nokuthi abukeka kanjani, kukhombisa ukulutheka kuma-anabolic steroids. Ngakho-ke akusona nje isidingo esingokwengqondo sokulondoloza imisipha etholwe ngabasebenzisi bezingwegwe. Amazinga aphezulu futhi ukuvimbela ukukhiqizwa kwakho kwe testosterone. Qaphela.

  • Umbuzo: Usunesikhathi esingakanani uku-HRT? Kunomtimba okhulayo wezincwadi ophakamisa ukuthi i-testosterone ephansi ibangela ushintsho esakhiweni sezicubu ze-erectile, okuholela ekungasebenzi kahle kwe-erectile. Uma i-testosterone yakho iqinisekisiwe ukuthi iphansi, lokhu kuyimbangela yezinkinga zakho zamanje. Ngenhlanhla, kukhonjisiwe ukuthi lezi zinguquko kwizicubu ze-erectile zibuyiselwa kakhulu kwi-HRT. Kungaba nengqondo ukulindela ukuthi kungathatha isikhathi eside ukuthi ukwenyuswa kwakho kuthuthuke kunalokho obekuzothatha ukuthi i-testosterone yakho ifinyelele emazingeni ajwayelekile, ngoba lokho ushintsho lomzimba wangempela emisipheni ebushelelezi, hhayi indaba elula yamazinga ama-hormone egazi. Ngenxa yelukuluku, ngingahle ngibuze iminyaka yakho, unesikhathi esingakanani uhlangabezana nezinkinga ze-erectile, nokuthi uthole isikhathi esingakanani ukwelashwa kuze kube manje?
  • Impendulo: Ngiku-HRT manje iminyaka emi-2. Ngineminyaka engama-40 manje. Ngibe ngumsubathi wezikhwepha ezingeni eliphansi iminyaka engu-20. Ngaleso sikhathi ngangivame ukusebenzisa ama-anabolic steroids (AAS). Lesi mhlawumbe yisizathu esenza ukuthi i-testosterone yami iphansi lapho ngiyeka ukusebenzisa i-AAS 3 eminyakeni edlule. Ngemuva konyaka owodwa wokululama amazinga ami e-testosterone endogenous ayengekho, kwaba yilapho ngiya ku-HRT. Iminyaka eyi-8 edlule, ikhwalithi yokwakhiwa kwami ​​ibimbi. Ngakho-ke, kulapho ngangikhona futhi ngiphuma ku-AAS nangesikhathi se-HRT. Kunezici eziningi kakhulu ezithintekayo kangangokuba kunzima ukusho ukuthi yini ebangela i-ED yami. Ngithemba ukuthi ukuqala kabusha kungangisiza kule nkinga. Njengamanje angazi ukuthi yiziphi ezinye izinketho enginazo.

Ukungahambi kahle ngokobulili kubangelwa ukunciphisa ukuguqulwa kwe-LH bioavailability.

I-Int J Impot Res. 2002 Apr; 14 (2): 93-9; ingxoxo ye-100.

Carosa E, Benvenga S, I-Trimarchi F, Lenzi A, I-Pepe M, Simonelli C, Jannini EA.

abstract

Sesanda kubhala ukuthi kunciphise kakhulu amazinga we-serum testosterone (T) kuziguli ezine-erectile dysfunction (ED). Ukuqonda indlela yalokhu i-hypotestosteronemia, eyayizimele etiology ye-ED, kanye nokubuyisela kwayo kuphela kwiziguli ezithinta izenzo zokwelapha ezihlukahlukene ze-nonhormonal, silinganisela i-horum luteinizing hormone (LH) eqenjini elifanayo labaguli be-ED ( n = 83; 70% i-organic, i-30% engekho emthethweni). Kokubili i-immunoreactive LH (I-LH) ne-bioactive LH (B-LH) yalinganiswa ekungeneni nasezinyangeni ze-3 ngemuva kokulashwa. Ngokususelwa kumphumela (isib. Imizamo yokuphumelela ngokocansi ngenyanga), iziguli zahlukaniswa njengezimpendulo ezigcwele (okungukuthi, imizamo eyisishiyagalombili; n = 51), izimpendulo eziyingxenye (okungenani umzamo owodwa; n = 20) nabangekho abaphenduli (n = 16). Uma kuqhathaniswa namadoda angama-30 anempilo angenayo i-ED, isisekelo se-B-LH (sisho +/- sd) ezigulini ezingama-83 sehlisiwe (13.6 +/- 5.5 vs 31.7 +/- 6.9 IU / L, P <0.001), ebusweni be kukhuphuke kancane, kepha kubanga elijwayelekile, I-LH (5.3 +/- 1.8 vs 3.4 +/- 0.9 IU / L, P <0.001); ngenxa yalokho, isilinganiso se-B / I LH sehlisiwe (3.6 +/- 3.9 vs 9.7 +/- 3.3, P <0.001). Ngokufana nokubuka kwethu kwangaphambilini kwe-serum T, amaqembu amathathu omphumela awazange ahluke kakhulu kunoma yimaphi emingcele emithathu. Noma kunjalo, amaqembu omphumela ahluke ngemva kokulashwa. Ukuzikhandla kwe-LH kwenyuka ngokuphawulekayo kubantu abaphendulile ngokugcwele (pre-therapy=13.7+/-5.3, post-therapy=22.6+/-5.4, P<0.001), ngokuthobeka ekuphenduleni okuyingxenye (14.8 +/- 6.9 vs 17.2 +/- 7.0, P <0.05) kodwa ahlale engashintshi kwabangewona abaphenduli (11.2 +/- 2.2 vs 12.2 +/- 5.1). Izinguquko ezihambisanayo ziye kolunye uhlangothi lwe-I-LH (5.2 +/- 1.7 vs 2.6 +/- 5.4, P <0.001; 5.4 +/- 2.2 vs 4.0 +/- 1.7, P <0.05; 5.6 +/- 1.2 vs 5.0 +/- 1.2, ngokulandelana), nasendaweni efanayo neB-LH yesilinganiso se-B / I (3.7 +/- 4.1 vs 11.8 +/- 7.8, P <0.001; 4.2 +/- 4.3 vs 5.8+ /-4.2, P <0.05; 2.1 +/- 0.7 vs 2.6 +/- 1.3, ngokulandelana). Sidinga ukuthi i-hypotestosteronemia yeziguli ze-ED ingenxa yokungasebenzi kahle kwe-LH. Lokhu kuncishisa ukuguquguquka kwezinto eziphilayo kungaguquguquka, uma nje ukuqala kabusha komsebenzi wezocansi kufezwa kungakhathaliseki ukuthi kuyindlela yokwelapha. Ngenxa yokuthi i-biopotency ye-hormone ye-pituitary ilawulwa yi-hypothalamus, i-LH hypoactivity kufanele ibe ngenxa yomonakalo osebenzayo we-hypothalamic ehambisana nokuphazanyiswa kwengqondo okungenakugwema ukulandela ukungasebenzi kwezocansi.

IZIMPENDULO: Abalobi basikisela ukuthi umsebenzi wobulili ophumelelayo ukwandisa i-LH kanye ne-testosterone emadodeni asetshenziselwe i-ED. Akukho namunye wabantu abathandekayo abaphathwa nge-hormone, futhi testosterone ephansi ayingeyona imbangela ye-ED yabo. Uma kuyiqiniso kumadoda aphilile, lokhu kusikisela ukuthi ucansi / ukujula kungavimbela ukuncipha kwamazinga e-testoterone.

IMIBUZO YOKUPHILA KWEZIMPILO NEZENZUZO ZOKUXHUMELWA KWESIKHATHI ESIKHENI

I-Scand J Psychol. 2003 Jul;44(3):257-63.

UFernández-Guasti A, Rodríguez-Manzo G.

abstract

Isihloko samanje sichaza ukutholakala kwamanje ngesenzakalo esithakazelisayo sokuzibandakanya ngokocansi. U-Knut Larsson ku-1956 wabika ngokuthuthukiswa kokukhathala ngokobulili kumlingani wesilisa ngemva kokuphindaphindiwe kokuphindaphindiwe. Sifunde inqubo futhi sathola imiphumela elandelayo.

(1) Ngolunye usuku ngemuva kwamahora angu-4 wokubambisana kwe-ad libitum, izingxenye ezimbili kwezintathu zabantu zibonisa ukuvinjelwa okuphelele kokuziphatha ngokocansi, kanti enye yesithathu ibonise uchungechunge olulodwa oluhlosiwe olungazange lusekho.

(2) ukwelashwa eziningana kwemithi, kuhlanganise 8-OH-DPAT, yohimbine, naloxone futhi naltrexone, ukuguqulwa satiety ngokobulili, okubonisa ukuthi noradrenergic, serotonergic futhi opiate izinhlelo abantu abahilelekile kule nqubo. Ngempela, izinqumo eziqondile ze-neurochemical zibonisa izinguquko ezinhlobonhlobo ze-neurotransmitters ngesikhathi sokuphelelwa yisifo socansi.

(3) Njengoba kunikezwe amandla okuvuselela okwanele, ngokushintsha isisusa sabantu besifazane, ukuhlukunyezwa ngokobulili kwavinjelwa, okuphakamisa ukuthi kukhona izingxenye zokugqugquzela ngokocansi ezihlukanisa ukucindezeleka ngokocansi.

(I-4) I-GABA ephikisanayo ne-bicuculline, noma ukuvuselela kagesi kwendawo yangaphambi kokuqala, ayizange ibuyele ekuqedeni ngokocansi. Le datha ibonisa ukuthi ngakwesinye isikhathi ukuthi ukukhathala ngokocansi kanye nekhefu lokuthunyelwa kwe-postejaculatory (elinciphiswe yi-bicuculline administration) alinganiselwe yizici ezifanayo futhi, ngakolunye uhlangothi, ukuthi indawo yangaphambili yezinto zangaphambili ayilawuli ukuhlukunyezwa ngokocansi.

(5) I-androgen receptor mass in izindawo zobuchopho ezihlobene eduze nokubonakaliswa kokuziphatha kwabantu ngokocansi, njenge-nucleus yangaphambi komzimba, yanciphisa kakhulu izilwane eziphethwe ngokocansi. Ukunciphisa okunjalo kwakuqondile ezindaweni ezithile zobuchopho futhi akuhambisani nezinguquko emazingeni e-androgens. Le miphumela iphakamisa ukuthi izinguquko ebucayini be-androgen receptors akhawunti yokuvimbela ukuziphatha ngokobulili okwamanje ngesikhathi sokukhathala ngokocansi.

(6) Inqubo yokutakula yokuhlukunyezwa ngokobulili ngemuva kwamahora angu-4 wokubambisana kwe-ad libitum yembula ukuthi ngemuva kwezinsuku ze-4, kuphela u-63% wabesilisa abakwazi ukubonisa ukuziphatha kocansi ngenkathi emva kwezinsuku ezingu-XNUM zonke izilwane zibonisa umsebenzi wokukopisha.

IMIBUZO: Ingxenye yobuchopho lapho ukwehla kwe-receptor kwenzeka khona kufana nokufana kakhulu kuzo zonke izilwane ezincelisayo. Uma lokhu kwehla ku-testosterone receptors kwenzeka kubantu besilisa, kungase kuchaze ukuthi kungani amanye amadoda ezwa sengathi i-testosterone yabo iphansi ngemuva kokunyuka okuvamile, nokuthi kungani bazizwa sengathi ama-testosterone awo aphakama ngesikhathi sokuziyeka.

QAPHELA: Lo mphumela wesikhashana ulinganiswa ebuchosheni obuvamile. Uma ubuchopho bakho buguqukile ngenxa yokulutha umuthi, i-dopamine yakho iphinde isetshenziswe, ngokungafani nokuncipha okwesikhashana kwe-testosterone receptors, futhi uzodinga isikhathi eside ukubuyela ku-libido evamile.

Futhi: # 4 - Ukukhathala ngokocansi kwavinjelwa ngokwethula owesifazane oyinoveli (yilokho okwenziwa yi-porn).

Ukwandiswa kwe-estrogen receptor alpha immunoreactivity ku-forebrain yamagundane ahlukunyezwa ngokocansi.

I-Horm Behav. 2007 Mar; 51 (3): 328-34. I-Epub 2007 Jan 19.

Phillips-Farfán BV, I-Lemus AE, I-Fernández-Guasti A.

abstract

I-alpha-receptor alpha (ERalpha) iqhaza emthethweni we-neuroendocrine wokuziphatha ngokobulili wesilisa, ngokuyinhloko ezindaweni ezibucayi ezisemgunyeni womzimba. Amadoda ezinhlobo eziningi anesimo eside sokuvimbela ukuziphatha ngokobulili ngemuva kokuqanjwa kwe-ejaculations eminingana, eyaziwa ngokuthi isifo socansi. Kuye kwaboniswa ukuthi inani le-androgen ye-receptor linciphisa i-24 h ngemuva kokukhipha okukodwa noma ukuxubha ukuze kube nesisindo, endaweni yangaphambili ye-preoptic, i-nucleus accumbens ne-ventromedial hypothalamus. Inhloso yalolu cwaningo kwakuwukuhlolisisa uma ubukhulu buka-ERalpha buphinde buguqulwe i-24 h ngemuva kokukhipha okukodwa noma ukuxubha ukuze kufinyeleleke. Ukuhlukumezeka ngokocansi kwakuhlotshaniswa nokukhula kwe-ERalpha ku-nucleus ye-bedrium ye-stria terminalis (i-BSTMA), i-ventrolateral septum (i-LSV), i-amygdala yangaphakathi (posterodorsal medial amygdala) (i-MePD), indawo yangaphambili yomphakathi (MPA) kanye nucleus accumbens core (NAc). Ukujula okukodwa kwakuhlobene nokwanda kwe-ERalpha isibalo ku-BSTMA ne-MePD. Ubuningi be-ERalpha kwi-arcuate (i-Arc) ne-ventromedial hypothalamic nuclei (i-VMN), futhi amazinga we-serum estradiol ahlala engashintshi i-24 h ngemuva kokukhipha noma ukuxubha. Le datha ibonisa ubudlelwane phakathi komsebenzi wocansi kanye nokwanda kwenkomba ye-ERalpha ezindaweni ezithile zobuchopho, ngaphandle kwamazinga e-estradiol ekujikelezweni kwesistimu.

IZIMPENDULO: Isisindo se-Estrogen receptors sisanda ezindaweni eziningana emva kokukhipha okukodwa, nokuhlukunyezwa ngokocansi. Esifundweni esigcwele basikisela ukuthi lolu shintsho luhlala isikhathi eside kunamahora angu-24.