Humusha i-Psychiatry. I-2013 Oct 1; 3: e308. doi: 10.1038 / tp.2013.81.
I-Thorgeirsson TE, I-Gudbjartsson DF, I-Sulem P, Besenbacher S, I-Styrkarsdottir U, Thorleifsson G, I-Walters GB; I-TAG Consortium; I-Oxford-GSK Consortium; I-ENGAGE Consortium, UFurberg H, Sullivan PF, UMashiini J, McCarthy MI, I-Steinthorsdottir V, I-Thorsteinsdottir U, Stefansson K.
Umthombo
I-Decode genetics / AMGEN, Sturlugata 8, Reykjavik, Iceland.
Ukubhema kuthonya isisindo somzimba njengokuthi ababhemayo abanesisindo esingaphansi kwalabo ababhemayo futhi ukuyeka ukubhema kuvame ukuholela ekonyuseni kwesisindo. Ubudlelwano obuphakathi kwesisindo somzimba nokubhema buchazwa ngokwengxenye ngomphumela we-nicotine on the appetite and metabolism. Kodwa-ke, uhlelo lomvuzo wobuchopho lubandakanyeka ekulawulweni kokudla kokubili kokudla nogwayi.
Sihlole umphumela we-single-nucleotide polymorphisms (SNPs) ezithinta i-body mass index (BMI) ngokuziphatha kokubhema, futhi sahlola ama-32 SNPs akhonjwe ekuhlaziyeni kwe-meta okuhambisana nokuhlangana kwama-phenotypes amabili, ukubhema ukuqala (SI) kanye nenani ugwayi wabhema ngosuku (i-CPD) kusampula yase-Iceland (N = 34 216). Kuhlanganiswe ngokusho komphumela wabo ku-BMI, i-SNPs ilungisa nge-SI (r = 0.019, P = 0.00054) ne-CPD (r = 0.032, P = 8.0 × 10-7). Lokhu okutholakele kuphindaphindeke kusethi enkulu yesibili yedatha (N = 127 274, kwayo ababhemayo be-76 242) kuzo zombili i-SI (P = 1.2 × 10-5) ne-CPD (P = 9.3 x 10-5). Ngokugqamile, ukuhlukahluka okuhlotshaniswa kakhulu ne-BMI (rs1558902-A ku-FTO) akuzange kuhambisane nokuziphatha okubhemayo. Ukuhlangana kokuziphatha ngokubhema akubangelwa umphumela wama-SNPs kwi-BMI. Imiphumela yethu ikhomba ngokuqinile kwisisekelo esivamile semvelo sokulawulwa kwesifiso sethu sikagwayi nokudla, futhi ngenxa yalokho ubungozi bokuluthwa umlutha we-nicotine kanye nokukhuluphala.
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