I-Neuroimage. 2015 Aug 7. pii: S1053-8119 (15) 00709-0. doi: 10.1016 / j.neuroimage.2015.08.001. [Epub phambili kokuphrinta]
UTuominen L1, UTuulari J2, Karlsson H2, UHirvonen J2, Helin S2, I-Salminen P3, IParkkola R4, UHietala J5, Nuutila P2, I-Nummenmaa L6.
abstract
Amasistimu we-Dopamine ne-opioid neurotransmitter ahlanganyela imisebenzi eminingi efana nokulawulwa komvuzo nenjabulo. Ama-receptors we-rec-Opioid (MOR) aguqula uhlelo lwe-mesolimbic dopamine endaweni ye-ventral tegmental endaweni kanye ne-striatum, izindawo ezibalulekile ezifakiwe emvuzweni. Sifakazele ukuthi ukutholakala kwe-dopamine ne-opioid receptor kufakwa ku-vivo nokuthi lokhu kuhlanganiswa kushintshwa ekukhuluphaleni, isifo esishintshiwe sokuhlawulwa kwemivuzo.
Izintokazi ezingamashumi amabili zenciphile (kusho i-BMI 22) ne-25 engadli ngokudla okunezifo ezinesizungu ngokweqile (zisho i-BMI 41) ezithathe ama-positron emission tomography ka-[11C] carfentanil kanye [11I-C] i-raclopride ukukala ukutholakala kwe-MOR ne-dopamine D2 receptor (DRD2), ngokulandelana.
Ezifundweni ezinciphile, ukutholakala kwe-MOR ne-DRD2 kuhlotshaniswe kahle ne-ventral striatum (r = 0.62, p = 0.003) ne i-dorsal caudate nucleus (r = 0.62, p = 0.004). Ngaphezu kwalokho, ukutholakala kwe-DRD2 ku-ventral striatum kwakuhlotshaniswa nokutholakala kwe-MOR kwezinye izifunda zomjikelezo wemivuzo, ikakhulukazi endaweni ephakathi nendawo.
In izifundo ezikhuluphele ngokweqile, lokhu kuxhumana kwe-receptor bebuthakathaka kakhulu ku-ventral striatum kepha bekungafakwanga ku-caudate nucleus.
Ekugcineni, ubudlelwano phakathi kokutholakala kwe-DRD2 endaweni ye-ventral striatum nokutholakala kwe-MOR endaweni ye-ventral tegmental kwaqedwa ku-morbidly feta.
Ucwaningo lukhombisa ukuxhumana phakathi kwe-DRD2 ne-MOR ukutholakala kwengqondo yomuntu ophilayo. Lokhu kuhlangana kuphazamiseka ngokukhethekile ohlelweni lwe-mesolimbic dopamine ekukhuluphaleni kwe-morbid. Siphakamisa ukuthi ukusebenzisana phakathi kwezinhlelo ze-dopamine ne-opioid kuyisidingo sokucutshungulwa kwemivuzo ejwayelekile futhi ukuphazamiseka kokukhuluma kungaphambanisa ukuguqulwa komvuzo emafutheni.
;