Biol Psychiatry. I-2015 Dec 2. pii: S0006-3223 (15) 00996-8. doi: 10.1016 / j.biopsych.2015.11.019.
UBrown RM1, Kupchik YM2, Spencer S3, Garcia-Keller C4, Spanswick DC5, Lawrence AJ6, Simonds SE5, USchwartz DJ3, IJordani KA3, Jou TC3, I-Kalivas PW3.
abstract
UMLANDO:
Kunobufakazi obukhulayo bokuthi i-pathological overeating engaphansi kwezinye izinhlobo zokukhuluphala iyaphoqeleka emvelweni ngakho-ke iqukethe izakhi zokuphazamiseka kwengqondo okuluthayo. Kodwa-ke, ubufakazi bokomzimba obuqondile obuhlanganisa ukukhuluphala neplastiki ye-synaptic njengalokho okuvela ekuluthweni buyantuleka. Sifune ukuthola ukuthi ubukhulu bokukhuluphala obudonswe ekudleni (i-DIO) buhambisana nokuziphatha okufana nomlutha, kanye nokuphazamiseka kwe-synaptic kulayini oyisisekelo se-nucleus accumbens okubhekwe njengezimpawu zokulutha.
IZINDLELA:
Ama-Sprague Dawley amagundane ayevunyelwa ukufinyelela mahhala ekudleni okunempilo kwamaviki e-8 abe esehlukaniswa ngenzuzo yesisindo kuma-Dio-prone kanye nama-Dio aqinile subgroups. Ukutholakala kokudla okuthandekayo bekukhawulelwe kumaseshini wokuzilawula we-opharetha nsuku zonke kusetshenziswa isilinganiso esilinganiselwe se-1, i-3, kanye ne-5 nama-ratio wokuthuthuka okuqhubekayo. Ngemuva kwalokho, kwalungiswa izicucu zobuchopho ze-nucleus, futhi sahlola izinguquko kwisilinganiso esiphakathi kwe-α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) ne-N-methyl-D-aspartate currents nekhono ukukhombisa ukudangala okuhlala isikhathi eside.
IZIPHUMA:
Sithole ukuthi ubukhulu bokuthuthukisa i-Dio buxhunyaniswa nokushoda emandleni okufaka ukucindezelwa kwesikhathi eside kuma-nucleus accumbens, kanye nokukhula okubangelwa yilezi zi-synapses njengoba kukalwa yi-AMPA / N-methyl-D-aspartate currents. Ngokuhambisana nalokhu kuphazamiseka, sibuke indlela yokuziphatha okufana nomlutha kumagundane ajwayelekile e-DIO, kufaka phakathi i-1) isisusa esikhuthazayo sokudla okuthandekayo; I-2) ukuphuza ngokweqile; kanye ne-3) kwandise ukufuna ukudla lapho ukudla kungatholakali.
IMIBUZO:
Imiphumela yethu ikhombisa ukugqama phakathi kokuqina kwe-DIO nezinguquko ezihambisana nezici zokuziphatha okuluthayo, okusekela ukungalingani okukhona okuhambisana nokuhlangana kwemizwa yokudla ngokweqile nokulutha kwezidakamizwa.
KEYWORDS:
Umlutha wokudla; I-Glutamate; Ukudangala okuhlala isikhathi eside; Ama-Nucleus accumbens; Ukukhuluphala; I-Synaptic plasticity
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