I-Psychoneuroendocrinology. 2015 Nov; 61: 53. i-doi: 10.1016 / j.psyneuen.2015.07.534. I-Epub 2015 Aug 8.
I-Chatzittofis A1, I-Arver S1, Öberg K1, IHholoberg J1, I-Nordström P1, J. Jokinen
Amaphuzu avelele
- Amadoda ane-hypersexual disorder ayenesilinganiso esiphezulu se-DST engeyona ukucindezelwa kunokulawula.
- Amadoda ane-hypersexual disorder ayenamazinga aphezulu e-DST-ACTH uma kuqhathaniswa nezilawuli.
abstract
Ukuphazamiseka kwe-hypersexual kuhlanganisa izici zengculazi, ukuhlukunyezwa ngokobulili, ukungabi nesifiso nokucindezela kwaphakanyiswa njengesifo se-DSM-5. Kodwa-ke, okuncane kuyaziwa nge-neurobiology ngemuva kwalesi sifo. Ukuhlukunyezwa kwe-hypothalamic pituitary adrenal (HPA) axis kuboniswe ukukhathazeka kwengqondo kepha akuphenywanga ukugula ngengqondo. Inhloso yalolu cwaningo kwakuwukuphenya umsebenzi we-axis i-HPA enkingeni ye-hypersexual.
Ucwaningo lubandakanya iziguli zesilisa ze-67 ezine-hypersexual disorder kanye namavolontiya abesilisa abasebenza nge-39. Amazinga e-plasma ama-cortisol ekuseni kanye ne-ACTH ahlolwe futhi ukuhlolwa kokunciphisa i-dexamethasone (0.5 mg) yokudonswa kwe-dexamethasone kwenziwa nge-cortisol ne-ACTH yokulinganisa ukuthunyelwa kwe-post dexamethasone. Isimo sokungaxhasi sichazwe ngamazinga we-DST-cortisol ≥138 nmol / l. Isikweletu se-Sexual Compulsive (SCS), isifo se-hypersexual esilinganisweni sokuhlola samanje (i-HD: CAS), i-Montgomery-Åsberg Ukucindezeleka Isilinganiso se-self-rating (MADRS-S) kanye ne-questionnaire ye-Childhood trauma (CTQ), yasetshenziselwa ukuhlola ukuziphatha kocansi, ukucindezeleka nokucindezeleka ukuhlupheka kokuqala.
Iziguli ezine-hypersexual disorder zazivame kakhulu kakhulu i-DST non-suppressors futhi zazinamazinga aphezulu kakhulu e-DST-ACTH uma kuqhathaniswa namavolontiya anempilo. Iziguli zabika ukukhathazeka okubaluleke kakhulu kwezingane kanye nezinkinga zokucindezeleka uma kuqhathaniswa namavolontiya anempilo. Izibalo ze-CTQ zibonise ukuhlanganiswa okungalungile okuphawulekayo ne-DST-ACTH kanti i-SCS ne-HD: Izikolo ze-CAS zibonise ukulungiswa okungalungile ne-cortisol eyisisekelo kwiziguli. Ukuxilongwa kwe-hypersexual disorder kwakuhlobene kakhulu ne-DST engeyona ukucindezela kanye ne-plasma ephakeme i-DST-ACTH ngisho nalapho ihlelwe ukuhlukunyezwa kwengane.
Imiphumela ibonisa ukuthi i-HPA i-dysregulation yezidakamizwa ezigulini zesilisa ezine-hypersexual disorder.
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