I-acrylic: Cwaninga ngezihloko ezinomlutha we-hypersexuality (umlutha wezocansi / wobulili) ubika ushintsho lwe-epigenetic oluvela kulabo abaphuza utshwala. Izinguquko ze-epigenetic zenzeka ezinhlotsheni ezihambisana nohlelo lwe-oxetocin (olubalulekile othandweni, ukubopha, umlutha, ukucindezela, njll.). Izithombe ezinhle kakhulu:
- Izimpawu ze-epigenetic zomlutha wezocansi / zocansi zohlelo lwe-oxytocin yobuchopho zibukeka zifana nezidakwa
- Ukutholwa kocwaningo kuhambisana ne Kuhn & Gallinat, I-2014 (isifundo esidumile se-fMRI kubasebenzisi be-porn)
- Ukutholwa kungakhombisa uhlelo lokuxineka olusebenzayo (okuwushintsho olukhulu kumlutha)
- Ukushintshwa kwezakhi zofuzo ze-oxetocin kungathinta ukubopha, ukucindezela, ukusebenza kocansi, njll.
Ukuze uthole okuningi, funda le ndatshana ye-technical lay: Ososayensi baveza i-hormone engase ihlanganiswe ne-hypersexual disorder
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U-Adrian E. Boström, u-Andreas Chatzittofis, u-Diana-Maria Ciuculete, uJohn N. Flanagan, uRegina Krattinger, uMarcus Bandstein, uJessica Mwinyi, uGerd A. Kullak-Ublick, uKatarina Görts Öberg, uStefan Arver, uHelgi B. Schiöth noJussi Jokinen (2019) )
I-Epigenetics, DOI: https://doi.org/10.1080/15592294.2019.1656157
abstract
I-Hypersexual disorder (HD) yaphakanyiswa njengokuxilongwa ku-DSM-5 futhi ukuhlukaniswa 'I-Compulsive Sexual Behaeve Disorder' manje sekuthunyelwa njengengozi yokulawula umthelela ku-ICD-11. I-HD ifaka izindlela ezithile ze-pathophysiological; kufaka phakathi ukuphoqelelwa, ukucindezelwa, ukufiswa kwesifiso sobulili kanye nokulutha kocansi. Akukho cwaningo olwedlule oluphenywe yi-HD ekuhlaziyweni kwe-methylation ekhawulelwe kuma-microRNA (miRNA) amasayithi ahambisana ne-CpG. Iphethini le-genome wide methylation lalinganiswa egazini eliphelele kusuka kwizifundo ze-60 ezine-HD kanye nama-33 amavolontiya anempilo asebenzisa i-Illumina EPIC BeadChip. Ama-8,852 miRNA ahlobene ne-CpG-amasayithi aphenywe ngokuhlaziya okuningana kwemigqa kwe-methylation M-amanani kuya kokuhlukahluka okuningana okuzimele kwesifo (i-HD noma ivolontiya elinempilo), kulungiswa ama-covariates azimisele ngokuphelele. Amazinga wokubonakaliswa kwama-miRNAs angenelwa ukhetho aphenywe kubantu abafanayo ukuhlaziya inkulumo ehlukile. I-mgidate methylation loci yafundelwa ukuhlangana nenhlangano yokuncika kotshwala esikhungweni esizimele se-107 yezifundo ezizimele. Iziza ezimbili ze-CpG zazibalulekile emngceleni ku-HD - cg18222192 (MIR708) (p <10E-05,pFDR = 5.81E-02) kanye ne-cg01299774 (MIR4456) (p <10E-06, pFDR = 5.81E-02). I-MIR4456 yehliswe kakhulu ekubonisweni kwe-HD kuzo zombili i-univariate (p <0.0001) kanye nokuhlaziywa kwe-multivariate (p <0.05). Amanqanaba e-Cg01299774 methylation ahlanganiswa ngokungafani namazinga wokukhuluma we-MIR4456 (p <0.01) futhi abuye ahlukaniswa ngokwehlukile ekuthembekeni kotshwala (p = 0.026). Ukuqagela kwelitshe le-Gene kanye nokuhlaziywa kwendlela kuveze ukuthi iMIR4456 ibhekisa ngokulinganayo izakhi zofuzo ezivezwe ngokukhethekile ebuchosheni futhi ezibandakanyeka ezinhlelweni ezinkulu zamangqamuzana e-neuronal okucatshangwa ukuthi zifanele i-HD, isb., Indlela esayina i-oxytocin. Ngokufingqa, ukutadisha kwethu kufaka umthelela ekunikeleni kwe-MIR4456 ku-pathophysiology ye-HD ngokuthonya ukusayina kwe-oxytocin.
KUSUKELA EKUGCINWENI ISIQEPHU
Ekuhlaziyweni kwenhlangano ye-DNA methylation egazini le-peripheral, sikhomba amasayithi we-CpG ahlukile ahlobene ne-MIR708 ne-MIR4456 ephawuleka ngokwehlukana kakhulu kwiziguli ze-HD. Ngaphezu kwalokho, sibonisa ukuthi i-hsamiR- 4456 ehambisana ne-methylation locus cg01299774 ngokwehluka ngokwe-methylated encike ekuncomeni kotshwala, siphakamisa ukuthi kungahlanganiswa ngokuyinhloko nengxenye yomlutha obonwe ku-HD.
Ngokwazi kwethu, alikho iphepha elidlule elachaza ukubaluleka kwe-MIR4456 kumongo we-psychopathologies. Sikhomba ukuthi le miRNA ilondolozwe ngokwemvelo mayelana nokubumbeka kokulandelana okuyinhloko futhi ibikezele izakhiwo zesekethe ze-hairpin kusukela ekuqubukeni kozimele. Ngaphezu kwalokho, sinikeza ubufakazi bokuthi okuhlosiwe kwe-mRNA okuhlosiwe kwe-MIR4456 kuboniswa ngokukhethekile kuma-amygdala kanye ne-hippocampus, izifunda ezimbili zobuchopho eziphakanyiswe nguKühn et al. ukufaka isandla ku-pathophysiology ye-HD [5].
Ukubandakanyeka kwendlela yokusayina ye-oxetocin ekhonjwe kulolu cwaningo kubonakala kunomthelela omkhulu ezimeni eziningi ezichaza i-HD njengoba kuhlongozwayo nguKafka et al. [I-1], njengokufisa kwesifiso sobulili, ukuphoqelela, ukufakwa kwezilingo kanye (nocansi) nomlutha. Ikhiqizwe ngokuyinhloko yi-nucleventricular nucleus ye-hypothalamus futhi ikhishwe yi-posterior pituitary, i-oxetocin idlala indima ebalulekile ekuzibopheni komphakathi nokuzala ngokobulili kwabesilisa nabesifazane [59]. UMurphy et al. kuchazwe amazinga aphezulu ngesikhathi sokuvuselela ucansi [60]. UBurri et al. ithole ukuthi isicelo se-intranasal oxytocin emadodeni saphumela ekwandeni kwamazinga e-plinma we-epinephrine ngesikhathi sokusebenza kobulili kanye nombono oshintshiwe we-arousal [61]. Ngokwengeziwe, kuhlongozwe ukuthi i-oxytocin ivimbele umsebenzi we-axothalamic-pituitary-adrenal (HPA) axis ngesikhathi sokuxineka. UJurek et al. uqaphele ukuthi ama-oxytocin receptormediated intracellular mechanisms ahlehlise ukuhanjiswa kwe-corticotropin-releasing factor (Crf) ku-nucleus ye-paturujeni, uhlobo oluhlobene ngokuqinile nempendulo yengcindezelo [62].
Ukushintshwa kwendlela esayina i-oxetocin kungachaza okutholwe nguChatzittofis et al., Obone ukungasebenzi kwe-axes kwe-HPA emadodeni ane-hypersexual disorder [3]. Ngaphezu kwalokho, ucwaningo lukhombisa ukuthi i-oxytocin ingahle ibandakanyeke ku-pathophysiology ye-obsessive-activive disorder [63]. Ukusebenzisana kwe-oxytocin nohlelo lwe-dopamine, i-HPA-axis kanye namasosha omzimba kuholele ekubethelelweni kokuthi ukungafani ngakunye kwamazinga e-oxetocin kunomthelela wobuthakathaka bokulutha [64]. Ngenkathi i-oxytocin ibikade ihlotshaniswa nokulawulwa kokuziphatha nenhlalo enobudlova, uJohansson et al. kubuye kwa bonisa ukuthi ukuhlukahluka kofuzo ku-oxytocin receptor gene (OXTR) kube nomthelela ekuthambekeleni kokuphendula ezimweni ezinamazinga aphezulu entukuthelo ngaphansi kwethonya lotshwala [65]. Okokugcina, uBrüne et al. waphetha ngokuthi ukuhlukahluka kofuzo ku-OXTR kungahle kube nomthelela ekuchazeni i-pathophysiology ye -lineline botho disorder [66], indlela yobuntu ebonakala ngokuqina okungahambi kahle kwe-dysregulation [66].
Ama-MIR4456may anomsebenzi ongezekile wokulawula ku-HD ongazange uvezwe ocwaningweni lwamanje. Ngokuhambisana nalokho esikutholile, ucwaningo lwangaphambilini lubike izinhlangano zokuziphatha kokuziphatha kobulili kwabesilisa kanye nezakhi zofuzo ezibandakanyeka ohlelweni lwe-glutamatergic kubantu abacindezelekile [i-67]. Ngaphezu kwalokho, indima engaba khona yamazinga we-3'-5'-cyclic adenosine mono phosphate (cAMP) ekubonweni kokuya ocansini yaboniswa kumagundane abesifazane, ngokushintsha i-phosphoprotein- 32 futhi kuholele ekushintsheni kwama-progestin receptors [68]. Kuyathakazelisa ukuthi i-cAMP futhi ilawula ama-molecule ahlotshaniswa nokuqondiswa kwe-axon [69], njenge-B3gnt1 gene, ehambisana nokuziphatha kocansi okungahambi kahle kumagundeni abesilisa
ISIHLOKO ESIPHELELE NGOKUFUNDA:
Ososayensi baveza i-hormone engase ihlanganiswe ne-hypersexual disorder
Ucwaningo olusha lwamadoda nabesifazane abane-hypersexual disorder luveze ukuthi kungenzeka ukuthi kukhona iqhaza le-oxytocin, ngokusho kwemiphumela eshicilelwe kule ncwadi. I-Epigenetics. Ukuthola kungavula iminyango yokwelapha lesi sifo ngobunjiniyela ngendlela yokucindezela umsebenzi wayo.
I-Hypersexual disorder, noma i-drive yokuya ocansini ngokweqile, ibonwa njengengxabano yokuziphatha kokuziphatha kobulili okuphoqelekile, ebhalwe njengenhlangano elawula ukungalawuleki yi-World Health Organisation. Kungabonakala ngemicabango yokubona ngocansi ngokweqile, ukuphoqelelwa ukwenza izenzo zocansi, ukulahleka kokulawula, noma imikhuba yezocansi ethwala izinkinga noma ubungozi obukhona. Ngenkathi isilinganiso sokwanda kwehlukahluka, izincwadi zibonisa ukuthi ukuphazamiseka kwe-hypersexual kuthinta i-3-6% yabantu.
Ukuphikisana kuzungeze ukuxilongwa ngoba kuvame ukwenzeka kanye nezinye izindaba zempilo yengqondo, kusikisela ukuthi kungaba ukwandiswa noma ukubonakaliswa kokuphazamiseka kwengqondo okukhona. Kuncane okwaziwayo nge-neurobiology ngemuva kwayo.
"Sizimisele ukuphenya izindlela zokulawula i-epigenetic ngemuva kwesifo se-hypersexual ukuze sikwazi ukubona ukuthi sinazo yini izimpawu ezenza sehluke kwezinye izindaba zezempilo," kusho umlobi oholayo u-Adrian Boström ovela eMnyangweni Wezobuchwepheshe e-Uppsala University, eSweden owayephethe funda nabaphenyi be-Andrology / Sexual Medicine Group (ANOVA) eKarlinska Institutet, eStockholm, eSweden.
"Ngokwazi kwethu, ukutadisha kwethu kungokokuqala ukufaka izindlela ze-epigenetic ezikhubazekile zombili umsebenzi we-DNA methylation kanye ne-microRNA kanye nokubandakanyeka kwe-oxytocin ebuchosheni ezigulini ezifuna ukwelashwa kobungqingili."
Ososayensi balinganise amaphethini e-DNA methylation egazini evela kwiziguli ze-60 ezine-hypersexual disorder futhi aziqhathanisa namasampula avela kwabasebenza ngokuzinikela be-33.
Baphenya izifunda ze-8,852 ze-DNA methylation ezihambisana nama-microRNA aseduze ukuthola noma yimuphi umehluko phakathi kwamasampula. I-methylation ye-DNA ingathinta ukubekwa kwezakhi zofuzo nokusebenza kwezakhi zofuzo, njengokujwayelekile ukwenza okuthile ukunciphisa umsebenzi wabo. Lapho kutholwe khona ushintsho ku-methylation ye-DNA, abacwaningi baphenya amazinga okuveza uhlobo lwe-microRNA ehlobene. Ama-MicroRNAs ayathakazelisa ikakhulukazi njengoba ekwazi ukudlulisela umgoqo wegazi-ubuchopho futhi alingise noma alimaze ukuveza izakhi zofuzo ezingaba ngamakhulu ambalwa ebuchosheni nakwezinye izicubu.
Baphinde baqhathanisa abakutholile namasampula aqhamuka kwizifundo ze-107, i-24 kuzo ezazincike otshwaleni, ukuthola inhlangano enokuziphatha okuluthayo.
Imiphumela ikhombe izifunda ezimbili ze-DNA ezashintshwa ezigulini ezinesifo i-hypersexual disc. Umsebenzi ojwayelekile we-DNA methylation waphazamiseka futhi i-microRNA ehambisana nayo, ebandakanyeka ekuthuliseni i-gene, yatholakala ukuthi ayivezwanga kahle. Ukuhlaziywa kwembula ukuthi i-microRNA ekhonjwe, i-microRNA-4456, ihlose izinhlobo zofuzo ezivame ukuvezwa emazingeni aphezulu kakhulu ebuchosheni futhi ezibandakanya ukulawulwa kwe-oxytocin ye-hormone. Ngokuncishwa kwe-gene kuncishisiwe, i-oxytocin kungenzeka kulindeleke ukuthi ibe sezingeni eliphezulu, yize ucwaningo lwamanje lungakuqinisekisi lokhu.
Kubonakale ezinhlotsheni ezithile ezi-vole nezisondelene i-neuropeptide oxytocin idlala indima ephambili kulawulo lokuziphatha ngokubopha. Ucwaningo lwangaphambilini luveze ukuthi i-oxetocin ihlotshaniswa nomthethonqubo wokuhlangana kwabantu nobabili, ukuzala ngokocansi kanye nokuziphatha okunolaka kwabesilisa nabesifazane. Ukuqhathaniswa nezifundo ezincike otshwaleni kuveze isifunda esifanayo se-DNA singaphansi kakhulu kwe-methylated, siphakamisa ukuthi kungahle kuhlotshaniswe ngokuyinhloko nezakhi zomlutha we-hypersexual disorder, njengokulutha kocansi, isifiso sobulili esingahambanga nalutho, ukucindezelwa kanye nokuphoqelelwa.
"Kuzodingeka olunye ucwaningo ukuphenya indima ye-microRNA-4456 ne-oxytocin ekuphazamisekeni kwe-hypersexual, kepha imiphumela yethu iphakamisa ukuthi kungakuhle ukuhlola izinzuzo zezidakamizwa nokwelashwa kwengqondo ukunciphisa umsebenzi we-oxytocin," kusho uSolwazi Jussi Jokinen wase-Umeå Inyuvesi, eSweden.
Ababhali baqaphela ukuthi umkhawulo ocwaningweni ukuthi umehluko omkhulu ku-DNA methylation phakathi kweziguli ezihlukumezanayo ezinempilo kanye namavolontiya anempilo ayengama-2.6% kuphela, ngakho-ke umthelela ekushintsheni komzimba kungabhekwa. Kodwa-ke, umzimba okhulayo wobufakazi bokuthi izinguquko nje ezicashile ze-methylation zingaba nemiphumela ebanzi yezimo eziyinkimbinkimbi ezifana nokudangala noma i-schizophrenia.
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Lolu cwaningo luxhaswe ngesivumelwano sesifunda phakathi kweMeå University kanye neVästerbotten County Council (ALF) nangezimali ezinikezwe iStockholm County Council kanye neSweden Research Foundation, i-Åhlens Foundation, iNovo Nordisk Foundation, neSweden Brain Research. Isisekelo.
ISIHLOKO SEBILI NGOKUFUNDA:
Izinguquko ze-Epigenetic Ezixhumene ne-Hypersexual Disorder kanye nama-Behaviors angama-Addictive
I-MedicalResearch.com Ingxoxo no: Adrian E. Boström MD, egameni lababhali
UMnyango weNeuroscience, Uppsala University, Sweden
I-MedicalResearch.com: Yini isizinda salolu cwaningo?
Impendulo: Ngenkathi isilinganiso sokwanda kwehlukahluka, izincwadi zibonisa ukuthi i-hypersexual disorder (HD) ithinta i-3-6% yabantu. Kodwa-ke, impikiswano izungeze ukuxilongwa futhi okuncane kuyaziwa nge-neurobiology ngemuva kwayo.
Isifo se-Hypersexual asikaze siphenywe maqondana ne-epigenomic ne-transcriptomics ngendlela yokufunda okungenayo i-hypothesis futhi kuncane okwaziwayo nge-neurobiology ngemuva kwalesi sifo. Siphenye ukuthi ngabe kukhona yini ushintsho lwe-epigenetic oluthinta ukusebenza kofuzo nokukhuluma ezigulini ze-hypersexual disorder (HD) saphinde sathola ne-microRNA ekhubazekile okukholelwa ukuthi inomthelela ekusebenzeni kwe-hormone oxytocin ebuchosheni.
I-Oxytocin yaziwa ukuthi inethonya lokuziphatha elibanzi. Ngokwazi kwethu konke, akukho cwaningo lwangaphambilini olwanikeza ubufakazi bokuhlangana phakathi kwe-DNA methylation, umsebenzi we-microRNA ne-oxytocin ekuphazamisekeni kwe-hypersexual. Okutholakele kwethu kufanelana nokucwaninga okuqhubekayo endimeni ye-MIR4456 futhi ikakhulukazi i-Oxytocin ekuphazamisekeni kwe-hypersexual. Izifundo ezengeziwe ziyadingeka ukuqinisekisa indima ye-Oxytocin ku-HD nokuphenya ukuthi ngabe ukwelashwa nge-oxytocin antagonist therapy therapy kungaba nemiphumela ezuzisayo ezigulini ezinesifo se-hypersexual.
I-MedicalResearch.com: Yini imiphumela esemqoka?
Impendulo: - Kulolu cwaningo siphenye nge-8000 ehlukile ye-methylation ye-DNA eyenziwe ngokulandelana ngendlela engenakho ukucabanga. Ngakho-ke, sahlabeka umxhwele futhi samangala ukuthola izinhlobo ezihlaselwe kakhulu ze-microRNA ezivezwa ngokuyinhloko ebuchosheni futhi zibandakanyeka ezindleleni ezinkulu zamangqamuzana ezinzwa ezisebenza njenge-efanele i-hypersexual disorder, isib. Lokhu i-microRNA futhi kubonakala njengokuziphendukela kwemvelo kulondoloziwe kuwo wonke ama-primates, nakho okutholakele okuthokozisayo nokungalindelekile.
I-MedicalResearch.com: Yini okufanele abafundi bayithathe kumbiko wakho?
Impendulo: I-Hypersexual disorder ifaka izindlela ezahlukahlukene ze-pathophysiological kufaka phakathi ukufakwa, ukucindezelwa, ukungafuneki kobulili kanye nokulutha kocansi. Lokhu kungahunyushwa ngokuthi i-hypersexual disorder iqukethe izinto eziluthayo, kepha akumele kubonwe njengokulutha kuphela. Ukuthola kwethu, ngokukhanya kwe-crossover nokuncika kotshwala, kuphakamisa ukuthi i-MIR4456 kanye ne-oxytocin signwaywayway road can be iqhaza ngokuyinhloko nengxenye yomlutha we-hypersexual disorder. Kudingeka ezinye izifundo ukufakazela lokhu ngokuphelele.
I-MedicalResearch.com: Yiziphi izincomo onazo zokucwaninga okuzayo ngenxa yalo msebenzi?
Impendulo: Imiphumela yethu igqugquzela ukuqhubeka kocwaningo ekusebenzeni, ngokwesibonelo, i-oxytocin elawula ukwelashwa kwezidakamizwa ekuphazamisekeni kwe-hypersexual okungaba nomthelela ezinkethweni zokwelashwa ezintsha ukwenza ngcono imiphumela yomtholampilo yalabo abathintekile. Ngaphezu kwalokho, sikhomba i-microRNA ethile (i-miRNA) ethize lapho i-miRNA engalawulwa khona yezidakamizwa engahlolwa ekuphazamisekeni kwe-hypersexual.
I-MedicalResearch.com: Ingabe kukhona okunye ongathanda ukukufaka?
Impendulo: I-DNA yethu iyikhodi yezakhi zofuzo ezihumusha ngokulandelana okuhlukile kwama-amino acid abizwa ngama-protein. Amaprotheni, nawo, akha into echaza zonke izinto eziphilayo. I-DNA yethu izuzwe njengefa futhi ayiguquki ngokuhamba kwesikhathi. Lolu cwaningo, nokho, beluphathelene ne-epigenetics, okuyizinguquko ezithinta ukusebenza kofuzo nokukhuluma. Le misebenzi ye-epigenetic iyashintsha ngokuhamba kwesikhathi futhi ingahle ilawulwe izifo ezithile. Kunezinqubo ezahlukahlukene ze-epigenetic.
Kulolu cwaningo, sifunde i-DNA methylation (inqubo eyaziwa ukuthonya ukubonakaliswa kofuzo, okungukuthi, ubuningi besakhi sofuzo esihunyushelwa kwiprotheni) nomsebenzi we-microRNA (izingxenye ezimfushane zofuzo ezingafakwanga ikhodi ezingaba nomthelela ekuhunyushweni kwamakhulu amaningana izakhi zofuzo ezahlukahlukene).
Uma siqhathanisa iziguli ezinesifo se-hypersexual namavolontiya anempilo, sikhombe ukulandelana kwe-DNA methylation ukuthi kuguqulwe kakhulu ekuphazamisweni kwe-hypersexual. Ukuze kutholakale ukubaluleka kwalokhu okutholakele, ukulandelana okufanayo kwe-DNA kukhonjiswe ngokuqhubekayo ukuthi kuncishisiwe ezifundweni ezinokuncika kotshwala, kuphakamisa ukuthi kungahle kuhlotshaniswe ngokuyinhloko nengxenye yokulutha yenkinga ye-hypersexual. Ukulandelana kwe-methylation ye-DNA ekhonjwe kuhlotshaniswa ne-microRNA ebizwa (i-microRNA 4456; i-MIR4456), nokuhlaziywa okuqhubekayo kukhombisile ukuthi lokhu kulandelana kwe-methylation ye-DNA kunomthelela kubungako be-MIR4456 obukhiqizwayo. Ngaphezu kwalokho, eqenjini elifanayo lokutadisha, sikhombisa ukuthi i-MIR4456 ikhona ngobuningi obuphansi kakhulu ekuphazamisekeni kwe-hypersexual uma kuqhathaniswa namavolontiya anempilo, iphakamisa ngokuqinile ukuthi kuguqulwe amaphethini we-DNA methylation kuthonya lokuphazamiseka kwe-hypersexual futhi inegalelo ekuchazeni ukuhlukunyezwa kwe-MIR4456. Njengoba i-microRNA: s ngokomqondo iyakwazi ukukhomba izakhi zofuzo ezingamakhulu amaningana, sisebenzise ama-algorithms ekhompyutha ukudalula ukuthi iMIR4456 ihlose izakhi zofuzo ezichazwe ngokukhethekile ebuchosheni futhi ezibandakanyeka ezinhlelweni ezinkulu zamangqamuzana ze-neuronal okucatshangwa ukuthi zifanele i-HD, isb., I-oxytocin ukusayina indlela. Okutholakele kwethu kufanelana nokucwaninga okuqhubekayo endimeni ye-MIR4456 futhi ikakhulukazi i-Oxytocin ekuphazamisekeni kwe-hypersexual. Izifundo ezengeziwe ziyadingeka ukuqinisekisa indima ye-Oxytocin ku-HD nokuphenya ukuthi ngabe ukwelashwa nge-oxytocin antagonist therapy therapy kungaba nemiphumela ezuzisayo ezigulini ezinesifo se-hypersexual.
Kodwa-ke imininingwane engashicilelwe ehlose ukutadisha okulandelanayo ehlukile ikhombisa ukwanda okuphawuleka kakhulu kwamazinga e-Oxytocin ezigulini ezinesifo se-hypersexual uma kuqhathaniswa nezilawuli, kanye nokwehliswa okukhulu kwamazinga e-oxytocin ngemuva kokwelashwa kwe-Cognitive Behaeve Therapy, okusho ngokuqinile indima eyimbangela ye-Oxytocin ku ukuphazamiseka kwe-hypersexual nokwenza izimangalo ezethulwe kulolu cwaningo ziqine kakhulu. Le miphumela yokuqala yethulwe njengephosta yokwephuka sekwephuzile emhlanganweni weSocial of Biological Psychiatry ngoMeyi 2019 futhi yathunyelwa njengephosta e-ACNP ngoDisemba 2019.
Isikhombo:
U-Adrian E. Boström et al, i-Hypermethylation ehlobene ne-microRNA-4456 ekuphazamisekeni kwe-hypersexual nethonya elibangelwa ukusayinwa kwe-oxytocin: Ukuhlaziywa kwe-methylation ye-DNA kwezakhi zemvelo ze-miRNA, I-Epigenetics (2019). I-DOI: 10.1080 / 15592294.2019.1656157
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